Raadpleeg ook de literatuurlijsten niet-toxische middelen en behandelingen specifiek bij borstkanker of specifiek bij chemo of stamceltransplantaties van arts-bioloog drs. Engelbert Valstar

14 februari 2020: Bron: JAMA

In JAMA van deze week presenteren de Nederlandse onderzoekers dr. Steenbruggen en collega's de 20-jarige follow-up van een Nederlandse studie van hoge dosis chemotherapie (HDC) en allogene stamceltransplantatie (ASCT) bij hoog-risico stadium III borstkanker. Alle subtypen van borstkanker werden meegenomen in de analyse, aangezien subtyping in de jaren negentig nog niet gestandaardiseerd was.

Over het algemeen was er geen duidelijk voordeel voor hoge dosis chemotherapie in vergelijking met standaard dosis chemo. Maar in een vooraf geplande analyse van patiënten met het hoogste risico ( patiënten met 10 of meer positieve lymfeklieren), was de algehele overleving met 14% verbeterd met hoge dosis chemotherapie plus stamceltransplantatie (HDC).
Bovendien was er in de groep patienten met triple negatieve borstkanker (AR neg, PR neg. en HER2 neg) waarvan nu inmiddels algemeen bekend is dat die gevoeliger is voor chemotherapie, een aanzienlijke verbetering van de resultaten met hoge dosis chemotherapie plus stamceltransplantatie.

Degenen die de hoge dosis chemotherapie plus stamceltransplantatie hadden gehad, hadden een verbeterde overall overleving  van 33%, wat zich vertaalde in een absoluut voordeel van 15,4% na 20 jaar op basis van overleving na ongeveer 10 jaar.

In de jaren negentig leek deze aanpak van borstkanker met hoge dosis chemotherapie plus stamceltransplantatie  geen goede behandeling voor borstkanker nadat fase III studies in 1999 op ASCO allemaal negatieve resultaten lieten zien. Maar door deze studie en door de veel betere selectie op basis van DNA mutaties en receptoren expressie blijkt de aanpak van hoge dosis chemotherapie plus stamceltranspalntatie nu weer wel een veel belovende behandeling te kunnen zijn. Nu dus ondersteund door deze studie van dr. Steenbruggen en collegaś .

Inmiddels loopt er ook een nieuwe fase III studie in het NKI - Nederlands Kanker Instituut: 

Substantially Improving the Cure Rate of High-risk BRCA1-like Breast Cancer (Subito)

 Het volledige studieverslag: High-Dose Chemotherapy With Hematopoietic Stem Cell Transplant in Patients With High-Risk Breast Cancer and 4 or More Involved Axillary Lymph Nodes 20-Year Follow-up of a Phase 3 Randomized Clinical Trial

is tegen betaling in te zien.

 
Key Points

Question  What are the 20-year efficacy and safety outcomes of adjuvant high-dose chemotherapy with hematopoietic stem cell transplant compared with conventional-dose chemotherapy for patients with stage III breast cancer?

Findings  This 20-year follow-up of a multicenter randomized phase 3 trial of 885 patients with stage III breast cancer showed no overall improvement in long-term survival after high-dose chemotherapy compared with conventional chemotherapy but showed clinically important survival benefit for patients with 10 or more involved axillary lymph nodes.

Meaning  Adjuvant high-dose chemotherapy with stem cell support should not be used in unselected patients with stage III breast cancer, but the survival benefit in subgroups of patients suggests that further research is needed.

Abstract

Importance  Trials of adjuvant high-dose chemotherapy (HDCT) have failed to show a survival benefit in unselected patients with breast cancer, but long-term follow-up is lacking.

Objective  To determine 20-year efficacy and safety outcomes of a large trial of adjuvant HDCT vs conventional-dose chemotherapy (CDCT) for patients with stage III breast cancer.

Design, Setting, and Participants  This secondary analysis used data from a randomized phase 3 multicenter clinical trial of 885 women younger than 56 years with breast cancer and 4 or more involved axillary lymph nodes conducted from August 1, 1993, to July 31, 1999. Additional follow-up data were collected between June 1, 2016, and December 31, 2017, from medical records, general practitioners, the Dutch national statistical office, and nationwide cancer registries. Analysis was performed on an intention-to-treat basis. Statistical analysis was performed from February 1, 2018, to October 14, 2019.

Interventions  Participants were randomized 1:1 to receive 5 cycles of CDCT consisting of fluorouracil, 500 mg/m2, epirubicin, 90 mg/m2, and cyclophosphamide, 500 mg/m2, or HDCT in which the first 4 cycles were identical to CDCT and the fifth cycle was replaced by cyclophosphamide, 6000 mg/m2, thiotepa, 480 mg/m2, and carboplatin, 1600 mg/m2, followed by hematopoietic stem cell transplant.

Main Outcomes and Measures  Main end points were overall survival and safety and cumulative incidence risk of a second malignant neoplasm or cardiovascular events.

Results  Of the 885 women in the study (mean age, 44.5 [6.6] years), 442 were randomized to receive HDCT, and 443 were randomized to receive CDCT. With 20.4 years median follow-up (interquartile range, 19.2-22.0 years), the 20-year overall survival was 45.3% with HDCT and 41.5% with CDCT (hazard ratio, 0.89; 95% CI, 0.75-1.06). The absolute improvement in 20-year overall survival was 14.6% (hazard ratio, 0.72; 95% CI, 0.54-0.95) for patients with 10 or more invoved axillary lymph nodes and 15.4% (hazard ratio, 0.67; 95% CI, 0.42-1.05) for patients with triple-negative breast cancer. The cumulative incidence risk of a second malignant neoplasm at 20 years or major cardiovascular events was similar in both treatment groups (20-year cumulative incidence risk for second malignant neoplasm was 12.1% in the HDCT group vs 16.2% in the CDCT group, P = .10), although patients in the HDCT group more often had hypertension (21.7% vs 14.3%, P = .02), hypercholesterolemia (15.7% vs 10.6%, P = .04), and dysrhythmias (8.6% vs 4.6%, P = .005).

Conclusions and Relevance  High-dose chemotherapy provided no long-term survival benefit in unselected patients with stage III breast cancer but did provide improved overall survival in very high-risk patients (ie, with ≥10 involved axillary lymph nodes). High-dose chemotherapy did not affect long-term risk of a second malignant neoplasm or major cardiovascular events.

Trial Registration  ClinicalTrials.gov Identifier: NCT03087409


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