Hyperthermie: Vrouw met uitgezaaide borstkanker en resistentie tegen chemo en hormoontherapie blijft minimaal 33 maanden klinisch kankervrij na combinatie behandeling van hyperthermie, bestraling en intra-arteriële toediening van herceptin

Mocht u kanker-actueel de moeite waard vinden en ons willen ondersteunen om kanker-actueel online te houden dan kunt u ons machtigen voor een periodieke donatie via donaties: https://kanker-actueel.nl/NL/donaties.html of doneer al of niet anoniem op - rekeningnummer NL79 RABO 0372931138 t.n.v. Stichting Gezondheid Actueel in Amersfoort. Onze IBANcode is NL79 RABO 0372 9311 38
Elk bedrag is welkom. En we zijn een ANBI instelling dus uw donatie of gift is in principe aftrekbaar voor de belasting.

En als donateur kunt u ook korting krijgen bij verschillende bedrijven:

https://kanker-actueel.nl/NL/voordelen-van-ops-lidmaatschap-op-een-rijtje-gezet-inclusief-hoe-het-kookboek-en-de-recepten-op-basis-van-uitgangspunten-van-houtsmullerdieet-te-downloaden-enof-in-te-zien.html

30 maart 2016: voor het volledige studierapport van opnderstaande studie abstract klikt u op de volgende PDF link: Hyperthermie bij borstkanker, een case studie

Onderaan een interessante referentielijst uit een andere studie met hyperthermie:

24 mei 2012: klik hier voor meer artikelen over hyperthermie bij borstkanker

22 maart 2012: wie het volledige studierapport van onderstaand artikel wilt lezen kan dit doen tegen betaling door hier te klikken.

11 mei 2005: Bron: Int J Clin Oncol. 2005 Apr;10(2):139-43.

Een wel heel bijzondere case studie maken Japanse onderzoekers bekend in het mei nummer van Int. J. Clinical Oncology. Het abstract is kort maar de tekst is heel duidelijk. De combinatie van hyperthermie, bestraling en intra-arteriële toediening van Herceptin - Trastuzumab brengt vrouw met gevorderde borstkanker bijna drie jaar verder - 33 maanden tot nu toe - waarin zich geen progressie van ziekte voordoet en zij zelfs klinisch kankervrij lijkt.

Advanced chemoresistant breast cancer responding to multidisciplinary treatment with hyperthermia, radiotherapy, and intraarterial infusion.

Yokoyama G, Fujii T, Ogo E, Yanaga H, Toh U, Yamaguchi M, Mishima M, Takamori S, Shirouzu K, Yamana H.
Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

We employed multidisciplinary therapy, consisting of hyperthermia, radiotherapy, and intraarterial infusion, for a patient with progressive advanced breast cancer that was resistant to epirubicin hydrochloride and cyclophosphamide (EC) therapy as well as being resistant to docetaxel hydrate, and obtained a good therapeutic response. Because estrogen and progesterone receptors were both negative and HER2 was 3(+), administration of trastuzumab was started, and this patient has shown no signs of recurrence at 33 months after our treatment. The results suggested that our multidisciplinary therapy can be an effective method for the treatment of progressive breast cancer showing resistance to major chemotherapy agents such as anthracyclines and taxanes.

PMID: 15864701 [PubMed - in process]

Referentielijst van hyperthermie bij kanker

References
1. Cihoric N, Tsikkinis A, van Rhoon G, Crezee H, Aebersold DM, Bodis S, Beck M, Nadobny J, Budach V, Wust P, Ghadjar P: Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2015:1-6.

2. Van der Zee J, González González D, Van Rhoon GC, van Dijk JDP, van Putten WLJ, Hart AA: Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 2000, 355:1119-1125.

3. Overgaard J, González González D, Hulshof MCCM, Arcangeli G, Dahl O, Mella O, Bentzen SM: Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology. Lancet 1995, 345:540-543.

4. Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, Van der Zee J, van Putten WLJ, Van Rhoon GC, van Dijk JDP, González González D, et al: Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. IntJRadiatOncolBiolPhys 1996, 35:731-744.

5. Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, Abdel-Rahman S, Daugaard S, Salat C, Wendtner CM, et al: Neo-adjuvant chemotherapy alone or
26
with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol 2010, 11:561-570.

6. Colombo R, Salonia A, Leib Z, Pavone-Macaluso M, Engelstein D: Long-term outcomes of a randomized controlled trial comparing thermochemotherapy with mitomycin-C alone as adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC). BJUInt 2011, 107:912-918.

7. Turner PF, Tumeh A, Schaefermeyer T: BSD-2000 approach for deep local and regional hyperthermia: physics and technology. StrahlentherOnkol 1989, 165:738741.

8. Crezee J, Van Haaren PMA, Westendorp H, De Greef M, Kok HP, Wiersma J, Van Stam G, Sijbrands J, Zum Vörde Sive Vörding PJ, Van Dijk JDP, et al: Improving locoregional hyperthermia delivery using the 3-D controlled AMC-8 phased array hyperthermia system : A preclinical study. IntJHyperthermia 2009, 25:581592.

9. Paulides MM, Bakker JF, Neufeld E, van der Zee J, Jansen PP, Levendag PC, van Rhoon GC: Winner of the "New Investigator Award" at the European Society of Hyperthermia Oncology Meeting 2007. The HYPERcollar: a novel applicator for hyperthermia in the head and neck. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2007, 23:567-576.

10. Franckena M, Fatehi D, de Bruijne M, Canters RA, van Norden Y, Mens JW, Van Rhoon GC, Van der Zee J: Hyperthermia dose-effect relationship in 420 patients with cervical cancer treated with combined radiotherapy and hyperthermia. EurJCancer 2009, 45:1969-1978.

11. Thrall DE, Larue SM, Yu D, Samulski T, Sanders L, Case B, Rosner G, Azuma C, Poulson J, Pruitt AF, et al: Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy. ClinCancer Res 2005, 11:52065214.

12. Wust P, Rau B, Gellerman J, Pegios W, Loffel J, Riess H, Felix R, Schlag PM: Radiochemotherapy and hyperthermia in the treatment of rectal cancer. Recent Results Cancer Res 1998, 146:175-191.

13. Van Rhoon GC, ... Why high quality hyperthermia is important, lessons to be learned (multi-institutional article). Radiation Oncology 2015.

14. Gellermann J, Faehling H, Mielec M, Cho CH, Budach V, Wust P: Image artifacts during MRT hybrid hyperthermia--causes and elimination. IntJHyperthermia 2008, 24:327-335.

15. Weihrauch M, Wust P, Weiser M, Nadobny J, Eisenhardt S, Budach V, Gellermann J: Adaptation of antenna profiles for control of MR guided hyperthermia (HT) in a hybrid MR-HT system. MedPhys 2007, 34:4717-4725.

16. Stakhursky VL, Arabe O, Cheng KS, Macfall J, Maccarini P, Craciunescu O, Dewhirst M, Stauffer P, Das SK: Real-time MRI-guided hyperthermia treatment using a fast adaptive algorithm. PhysMedBiol 2009, 54:2131-2145.

17. Gellermann J, Wlodarczyk W, Hildebrandt B, Ganter H, Nicolau A, Rau B, Tilly W, Fahling H, Nadobny J, Felix R, Wust P: Noninvasive magnetic resonance thermography of recurrent rectal carcinoma in a 1.5 Tesla hybrid system. Cancer Res 2005, 65:5872-5880.

18. Gellermann J, Hildebrandt B, Issels R, Ganter H, Wlodarczyk W, Budach V, Felix R, Tunn PU, Reichardt P, Wust P: Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia: correlation with response and direct thermometry. Cancer 2006, 107:1373-1382.
27

19. Fani F, Schena E, Saccomandi P, Silvestri S: CT-based thermometry: an overview. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2014, 30:219-227.

20. Paulides MM, Stauffer PR, Neufeld E, Maccarini PF, Kyriakou A, Canters RA, Diederich CJ, Bakker JF, Van Rhoon GC: Simulation techniques in hyperthermia treatment planning. IntJHyperthermia 2013, 29:346-357.

21. Gellermann J, Wust P, Stalling D, Seebass M, Nadobny J, Beck R, Hege H, Deuflhard P, Felix R: Clinical evaluation and verification of the hyperthermia treatment planning system hyperplan. IntJRadiatOncolBiolPhys 2000, 47:1145-1156.

22. Sreenivasa G, Gellermann J, Rau B, Nadobny J, Schlag P, Deuflhard P, Felix R, Wust P: Clinical use of the hyperthermia treatment planning system HyperPlan to predict effectiveness and toxicity. IntJRadiatOncolBiolPhys 2003, 55:407-419.

23. Van Haaren PMA, Kok HP, Van den Berg CAT, PJ ZVSV, Oldenborg S, Stalpers LJ, Schilthuis MS, De Leeuw AAC, Crezee J: On verification of hyperthermia treatment planning for cervical carcinoma patients. IntJHyperthermia 2007, 23:303-314.

24. Rijnen Z, Bakker JF, Canters RA, Togni P, Verduijn GM, Levendag PC, Van Rhoon GC, Paulides MM: Clinical integration of software tool VEDO for adaptive and quantitative application of phased array hyperthermia in the head and neck. IntJHyperthermia 2013, 29:181-193.

25. Franckena M, Canters R, Termorshuizen F, Van der Zee J, Van Rhoon GC: Clinical implementation of hyperthermia treatment planning guided steering: A cross over trial to assess its current contribution to treatment quality. IntJHyperthermia 2010, 26:145-157.

26. Kok HP, Ciampa S, De Kroon-Oldenhof R, Steggerda-Carvalho EJ, Van Stam G, Zum Vörde Sive Vörding PJ, Stalpers LJA, Geijsen ED, Bardati F, Bel A, Crezee J: Toward on-line adaptive hyperthermia treatment planning: correlation between measured and simulated specific absorption rate changes caused by phase steering in patients. IntJRadiatOncolBiolPhys 2014, 90:438-445.

27. Juang T, Stauffer PR, Craciunescu OA, Maccarini PF, Yuan Y, Das SK, Dewhirst MW, Inman BA, Vujaskovic Z: Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2014, 30:176-183.

28. Kroeze H, Kokubo M, van de Kamer JB, De Leeuw AAC, Kikuchi M, Hiraoka M, Lagendijk JJW: Comparison of a Capacitive and a Cavity Slot Radiative applicator for Regional Hyperthermia. Japanese Journal of Hyperthermic Oncology 2002, 18:75-91.

29. Paulsen KD, Geimer S, Tang J, Boyse WE: Optimization of pelvic heating rate distributions with electromagnetic phased arrays. IntJHyperthermia 1999, 15:157186.

30. Seebass M, Beck R, Gellermann J, Nadobny J, Wust P: Electromagnetic phased arrays for regional hyperthermia: optimal frequency and antenna arrangement. IntJHyperthermia 2001, 17:321-336.

31. Kok HP, De Greef M, Borsboom PP, Bel A, Crezee J: Improved power steering with double and triple ring waveguide systems: the impact of the operating frequency. IntJHyperthermia 2011, 27:224-239.

32. Kroeze H, van de Kamer JB, De Leeuw AAC, Lagendijk JJW: Regional hyperthermia applicator design using FDTD modelling. PhysMedBiol 2001, 46:1919-1935.
28

33. De Greef M, Kok HP, Correia D, Borsboom PP, Bel A, Crezee J: Uncertainty in hyperthermia treatment planning: the need for robust system design. PhysMedBiol 2011, 56:3233-3250.

34. Togni P, Rijnen Z, Numan WC, Verhaart RF, Bakker JF, van Rhoon GC, Paulides MM: Electromagnetic redesign of the HYPERcollar applicator: toward improved deep local head-and-neck hyperthermia. Phys Med Biol 2013, 58:5997-6009.

35. Trujillo-Romero CJ, Paulides MM, Drizdal T, van Rhoon GC: Impact of silicone and metal port-a-cath implants on superficial hyperthermia treatment quality. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2015, 31:15-22.

36. Cheng KS, Stakhursky V, Stauffer P, Dewhirst M, Das SK: Online feedback focusing algorithm for hyperthermia cancer treatment. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2007, 23:539-554.

37. Bruggmoser G, Bauchowitz S, Canters R, Crezee H, Ehmann M, Gellermann J, Lamprecht U, Lomax N, Messmer MB, Ott O, et al: Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia: quality management in regional deep hyperthermia. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft [et al] 2012, 188 Suppl 2:198-211.

38. Myerson RJ, Moros EG, Diederich CJ, Haemmerich D, Hurwitz MD, Hsu IC, McGough RJ, Nau WH, Straube WL, Turner PF, et al: Components of a hyperthermia clinic: recommendations for staffing, equipment, and treatment monitoring. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2014, 30:1-5.

39. Gabriel C, Gabriel S, Corthout E: The dielectric properties of biological tissues: I. Literature survey. PhysMedBiol 1996, 41:2231-2249.

40. Hornsleth SN, Mella O, Dahl O: A new segmentation algorithm for finite difference based treatment planning systems. In Hyperthermic Oncology 1996 vol 2. Edited by Franconi C, Arcangeli G, Cavaliere R. Rome, Italy Tor Vergata; 1996: p. 521-523

41. Wust P, Nadobny J, Seebass M, Stalling D, Gellermann J, Hege HC, Deuflhard P, Felix R: Influence of patient models and numerical methods on predicted power deposition patterns. IntJHyperthermia 1999, 15:519-540.

42. Fortunati V, Verhaart RF, van der Lijn F, Niessen WJ, Veenland JF, Paulides MM, van Walsum T: Tissue segmentation of head and neck CT images for treatment planning: a multiatlas approach combined with intensity modeling. Medical physics 2013, 40:071905.

43. Verhaart RF, Fortunati V, Verduijn GM, van der Lugt A, van Walsum T, Veenland JF, Paulides MM: The relevance of MRI for patient modeling in head and neck hyperthermia treatment planning: A comparison of CT and CT-MRI based tissue segmentation on simulated temperature. Medical physics 2014, 41:123302.

44. van de Kamer JB, Van Wieringen N, De Leeuw AAC, Lagendijk JJW: The significance of accurate dielectric tissue data for hyperthermia treatment planning. IntJHyperthermia 2001, 17:123-142.

45. Farace P, Pontalti R, Cristoforetti L, Antolini R, Scarpa M: An automated method for mapping human tissue permittivities by MRI in hyperthermia treatment planning. PhysMedBiol 1997, 42:2159-2174.
29

46. Mazzurana M, Sandrini L, Vaccari A, Malacarne C, Cristoforetti L, Pontalti R: A semi-automatic method for developing an anthropomorphic numerical model of dielectric anatomy by MRI. PhysMedBiol 2003, 48:3157-3170.

47. Balidemaj E, Van Lier ALHMW, Crezee H, Nederveen AJ, Stalpers LJA, Van den Berg CAT: Feasibility of Electric Property Tomography of pelvic tumors at 3T. Magn ResonMed 2015, 73:1505-1513.

48. Katscher U, Voigt T, Findeklee C, Vernickel P, Nehrke K, Dossel O: Determination of electric conductivity and local SAR via B1 mapping. IEEE TransMedImaging 2009, 28:1365-1374.

49. Balidemaj E, Trinks J, Van den Berg CAT, Nederveen AJ, van Lier AL, Stalpers LJA, Crezee J, Remis RF: CSI-EPT: A novel contrast source approach to MRI based electric properties tomography and patient-specific SAR. DOI: 10.1109/ICEAA.2013.6632328. International Conference on Electromagnetics in Advanced Applications (ICEAA), 2013 2013:668-671.

50. Van den Berg PM, Abubakar A: Contrast source inversion method: state of art. Progress in Electromagnetics Research 2001, 34:189-218.

51. Canters RA, Franckena M, Paulides MM, Van Rhoon GC: Patient positioning in deep hyperthermia: influences of inaccuracies, signal correction possibilities and optimization potential. PhysMedBiol 2009, 54:3923-3936.

52. De Greef M, Kok HP, Bel A, Crezee J: 3-D versus 2-D steering in patient anatomies: a comparison using hyperthermia treatment planning. IntJHyperthermia 2011, 27:74-85.

53. Winter L, Ozerdem C, Hoffmann W, Santoro D, Muller A, Waiczies H, Seemann R, Graessl A, Wust P, Niendorf T: Design and Evaluation of a Hybrid Radiofrequency Applicator for Magnetic Resonance Imaging and RF Induced Hyperthermia: Electromagnetic Field Simulations up to 14.0 Tesla and Proof-ofConcept at 7.0 Tesla. PloS one 2013, 8.

54. Dobsicek Trefna H, Vrba J, Persson M: Evaluation of a patch antenna applicator for time reversal hyperthemia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2010, 26:185-197.

55. Paulides MM, Vossen SH, Zwamborn AP, van Rhoon GC: Theoretical investigation into the feasibility to deposit RF energy centrally in the head-and-neck region. International journal of radiation oncology, biology, physics 2005, 63:634-642.

56. Hand JW: Modelling the interaction of electromagnetic fields (10 MHz-10 GHz) with the human body: methods and applications. Phys Med Biol 2008, 53:R243286.

57. Deuflhard P, Schiela A, Weiser M: Mathematical cancer therapy planning in deep regional hyperthermia. Acta Numerica 2012, 21:307-378.

58. Mur G: Absorbing boundary condition for the finite difference approximation of the time-domain electromagnetic-field equations. IEEE TransElectromagnCompatEMC-23 1981:377-382.

59. Berenger JP: A Perfectly Matched Layer for the Absorption of ElectromagneticWaves. Journal of Computational Physics 1994, 114:185-200.

60. Berntsen S, Hornsleth SN: Retarded Time Absorbing Boundary-Conditions. Ieee Transactions on Antennas and Propagation 1994, 42:1059-1064.

61. Bayliss A, Turkel E: Radiation boundary conditions for wavelike equations. CommunPure ApplMath 1980, 33:707-725.

62. Taflove A: The Finite-Difference Time-Domain Method. (Boston, USA: Artech House); 1995.
30

63. Yee KS: Numerical solution of initial boundary value problems involving Maxwell’s equations in isotropic media. IEEE Trans Antennas Propag 1966, 14:302-307.

64. Nadobny J, Sullivan D, Wust P, Seebass M, Deuflhard P, Felix R: A high-resolution interpolation at arbitrary interfaces for the FDTD method. Ieee Transactions on Microwave Theory and Techniques 1998, 46:1759-1766.

65. Das SK, Clegg ST, Anscher MS, Samulski TV: Simulation of electromagnetically induced hyperthermia: a finite element gridding method. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1995, 11:797-808.

66. Paulsen KD, Jia XL, Sullivan JM: Finite-Element Computations of Specific Absorption Rates in Anatomically Conforming Full-Body Models for Hyperthermia Treatment Analysis. Ieee Transactions on Biomedical Engineering 1993, 40:933-945.

67. Löhner R, Parikh P: Generation of three-dimensional unstructured grids by the advancing-front method. Int J Numer Methods Fluids 1988, 8:1135-1149.

68. Mohamed A, Davatzikos C: Finite element mesh generation and remeshing from segmented medical images. Proc IEEE Int Symp on Biomedical Imaging (April 2004) 2004, 1:420-423.

69. Weiland T: Discretization Method for Solution of Maxwells Equations for 6Component Fields. Aeu-Int J Electron C 1977, 31:116-120.

70. Wust P, Nadobny J, Seebass M, Dohlus JM, John W, Felix R: 3-D Computation of E-Fields by the Volume-Surface Integral-Equation (Vsie) Method in Comparison with the Finite-Integration Theory (Fit) Method. Ieee Transactions on Biomedical Engineering 1993, 40:745-759.

71. Zwamborn P, Vandenberg PM: The 3-Dimensional Weak Form of the ConjugateGradient Fft Method for Solving Scattering Problems. Ieee Transactions on Microwave Theory and Techniques 1992, 40:1757-1766.

72. Zwamborn APM, Van den Berg PM, Mooibroek J, Koenis FTC: Computation of three-dimensional electromagnetic-field distributions in a human body using the weak form of the CGFFT method. Applied Computational Electromagnetic Soc 1992, 7:26-42.

73. Song CW: Effect of local hyperthermia on blood flow and microenvironment: a review. Cancer Res 1984, 44:4721s-4730s.

74. Wust P, Stahl H, Loffel J, Seebass M, Riess H, Felix R: Clinical, physiological and anatomical determinants for radiofrequency hyperthermia. IntJHyperthermia 1995, 11:151-167.

75. Tilly W, Wust P, Rau B, Harder C, Gellermann J, Schlag P, Budach V, Felix R: Temperature data and specific absorption rates in pelvic tumours: predictive factors and correlations. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2001, 17:172-188.

76. De Greef M, Kok HP, Correia D, Bel A, Crezee J: Optimization in hyperthermia treatment planning: the impact of tissue perfusion uncertainty. MedPhys 2010, 37:4540-4550.

77. Bhowmik A, Singh R, Repaka R, Mishra SC: Conventional and newly developed bioheat transport models in vascularized tissues: A review. Journal of Thermal Biology 2013, 38:107-125.
31

78. Kok HP, Gellermann J, Van den Berg CA, Stauffer PR, Hand JW, Crezee J: Thermal modelling using discrete vasculature for thermal therapy: A review. IntJHyperthermia 2013, 29:336-345.

79. Pennes HH: Analysis of tissue and arterial blood temperatures in the resting human forearm. 1948. JApplPhysiol 1948, 1:93-122.

80. Wulff W: The energy conservation equation for living tissue. IEEE TransBiomedEng 1974, 21:494-495.

81. Chen MM, Holmes KR: Microvascular contributions in tissue heat transfer. Annals of the New York Academy of Sciences 1980, 335:137-150.

82. Weinbaum S, Jiji LM: The Matching of Thermal Fields Surrounding Countercurrent Microvessels and the Closure Approximation in the WeinbaumJiji Equation. Journal of Biomechanical Engineering-Transactions of the Asme 1989, 111:271-275.

83. Crezee J, Lagendijk JJ: Temperature uniformity during hyperthermia: the impact of large vessels. PhysMedBiol 1992, 37:1321-1337.

84. Moros EG, Straube WL, Myerson RJ: Finite difference vascular model for 3-D cancer treatment with hyperthermia. In Advances in Biological and Heat and Mass Transfer Volume IITD-286. Edited by Roemer RB: ASME Heat Transfer Division; 1993: 107-111

85. Lagendijk JJ: The influence of bloodflow in large vessels on the temperature distribution in hyperthermia. PhysMedBiol 1982, 27:17-23.

86. Rawnsley RJ, Roemer RB, Dutton AW: The simulation of discrete vessel effects in experimental hyperthermia. JBiomechEng 1994, 116:256-262.

87. Mitchell JW, Myers GE: An analytical model of the counter-current heat exchange phenomena. BiophysJ 1968, 8:897-911.

88. Lagendijk JJ, Schellekens M, Schipper J, van der Linden PM: A three-dimensional description of heating patterns in vascularised tissues during hyperthermic treatment. PhysMedBiol 1984, 29:495-507.

89. Mooibroek J, Lagendijk JJ: A fast and simple algorithm for the calculation of convective heat transfer by large vessels in three-dimensional inhomogeneous tissues. IEEE TransBiomedEng 1991, 38:490-501.

90. Kotte AN, van Leeuwen GM, Lagendijk JJ: Modelling the thermal impact of a discrete vessel tree. PhysMedBiol 1999, 44:57-74.

91. Kok HP, Van den Berg CAT, Bel A, Crezee J: Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. MedPhys 2013, 40:103303.

92. Huang HW, Chen ZP, Roemer RB: A counter current vascular network model of heat transfer in tissues. JBiomechEng 1996, 118:120-129.

93. Kotte ANTJ, van Leeuwen GMJ, de Bree J, van der Koijk JF, Crezee J, Lagendijk JJW: A description of discrete vessel segments in thermal modelling of tissues. PhysMedBiol 1996, 41:865-884.

94. Raaymakers BW, Crezee J, Lagendijk JJ: Modelling individual temperature profiles from an isolated perfused bovine tongue. PhysMedBiol 2000, 45:765-780.

95. Craciunescu OI, Raaymakers BW, Kotte AN, Das SK, Samulski TV, Lagendijk JJ: Discretizing large traceable vessels and using DE-MRI perfusion maps yields numerical temperature contours that match the MR noninvasive measurements. MedPhys 2001, 28:2289-2296.

96. Van den Berg CAT, van de Kamer JB, De Leeuw AAC, Jeukens CRLPN, Raaymakers BW, Van Vulpen M, Lagendijk JJW: Towards patient specific thermal modelling of the prostate. PhysMedBiol 2006, 51:809-825.
32

97. van Leeuwen GM, Kotte AN, Lagendijk JJ: A flexible algorithm for construction of 3-D vessel networks for use in thermal modeling. IEEE TransBiomedEng 1998, 45:596-604.

98. Prishvin M, Zaridze R, Bit-Babik G, Faraone A: Improved numerical modelling of heat transfer in human tissue exposed to RF energy. Australasian Physical & Engineering Sciences in Medicine 2010, 33:307-317.

99. Bardati F, Borrani A, Gerardino A, Lovisolo GA: SAR optimization in a phased array radiofrequency hyperthermia system. Specific absorption rate. IEEE TransBiomedEng 1995, 42:1201-1207.

100. Kohler T, Maass P, Wust P, Seebass M: A fast algorithm to find optimal controls of multiantenna applicators in regional hyperthermia. PhysMedBiol 2001, 46:25032514.

101. Eberhart RC, Kennedy J: A new optimizer using particles swarm theory. Proc Sixth International Symposium on Micro Machine and Human Science (Nagoya, Japan) 1995:39-43.

102. Siauve N, Nicolas L, Vollaire C, Marchal C: Optimization of the sources in local hyperthermia using a combined finite element-genetic algorithm method. International Journal of Hyperthermia 2004, 20:815-833.

103. Liu Y, Qin Z, Shi Z: Hybrid Particle Swarm Optimizer with Line Search. IEEE International Conference on Systems, Man and Cybernetics 2004:3751-3755.

104. Canters RA, Wust P, Bakker JF, Van Rhoon GC: A literature survey on indicators for characterisation and optimisation of SAR distributions in deep hyperthermia, a plea for standardisation. IntJHyperthermia 2009, 25:593-608.

105. Paulides MM, Bakker JF, Linthorst M, van der ZJ, Rijnen Z, Neufeld E, Pattynama PM, Jansen PP, Levendag PC, Van Rhoon GC: The clinical feasibility of deep hyperthermia treatment in the head and neck: new challenges for positioning and temperature measurement. PhysMedBiol 2010, 55:2465-2480.

106. Wust P, Seebass M, Nadobny J, Deuflhard P, Monich G, Felix R: Simulation studies promote technological development of radiofrequency phased array hyperthermia. IntJHyperthermia 1996, 12:477-494.

107. Das SK, Clegg ST, Samulski TV: Computational techniques for fast hyperthermia temperature optimization. MedPhys 1999, 26:319-328.

108. Cheng KS, Stakhursky V, Craciunescu OI, Stauffer P, Dewhirst M, Das SK: Fast temperature optimization of multi-source hyperthermia applicators with reduced-order modeling of 'virtual sources'. PhysMedBiol 2008, 53:1619-1635.

109. Kok HP, Van Haaren PMA, van de Kamer JB, Zum Vörde Sive Vörding PJ, Wiersma J, Hulshof MCCM, Geijsen ED, van Lanschot JJB, Crezee J: Prospective treatment planning to improve locoregional hyperthermia for oesophageal cancer. IntJHyperthermia 2006, 22:375-389.

110. Wust P, Weihrauch M: Hyperthermia classic commentary: 'Simulation studies promote technological development of radiofrequency phased array hyperthermia' by Peter Wust et al., International Journal of Hyperthermia 1996;12:477-494. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2009, 25:529-532.

111. Ranneberg M, Weiser M, Weihrauch M, Budach V, Gellermann J, Wust P: Regularized antenna profile adaptation in online hyperthermia treatment. Medical physics 2010, 37:5382-5394.

112. Numan WC, Hofstetter LW, Kotek G, Bakker JF, Fiveland EW, Houston GC, Kudielka G, Yeo DT, Paulides MM: Exploration of MR-guided head and neck
33
hyperthermia by phantom testing of a modified prototype applicator for use with proton resonance frequency shift thermometry. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2014, 30:184-191.

113. Craciunescu OI, Das SK, McCauley RL, MacFall JR, Samulski TV: 3D numerical reconstruction of the hyperthermia induced temperature distribution in human sarcomas using DE-MRI measured tissue perfusion: validation against noninvasive MR temperature measurements. IntJHyperthermia 2001, 17:221-239.

114. Verhaart RF, Rijnen Z, Fortunati V, Verduijn GM, Walsum TV, Veenland JF, Paulides MM: Temperature simulations in hyperthermia treatment planning of the head and neck region : Rigorous optimization of tissue properties. StrahlentherOnkol 2014.

115. Dos Santos I, Haemmerich D, Schutt D, da Rocha AF, Menezes LR: Probabilistic finite element analysis of radiofrequency liver ablation using the unscented transform. Phys Med Biol 2009, 54:627-640.

116. Prakash P, Deng G, Converse MC, Webster JG, Mahvi DM, Ferris MC: Design optimization of a robust sleeve antenna for hepatic microwave ablation. Physics in Medicine and Biology 2008, 53:1057-1069.

117. Kok HP, Crezee J, Franken NAP, Stalpers LJA, Barendsen GW, Bel A: Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions. IntJRadiatOncolBiolPhys 2014, 88:739-745.

118. Crezee J, ... Biological modeling of the radiation dose escalation effect of regional hyperthermia in cervical cancer. Radiation Oncology 2015.

multidisciplinary, progressive, infusion, kurume, hyperthermia, trastuzumab, intraarterial, resistant