1 december 2011: wie van onderstaande studie het volledige studieverslag wilt inzien kan dat doen door hier te klikken. u moet er  wel voor betalen, maar misschien kunt u dit ook opvragen bj het AvL - Amsterdam, waar deze studie is uitgevoerd

16 juli 2007: Bron: Clinical OtolaryngologyVolume 32, Issue 3pages 185–189, June 2007

PDT - Photo Dynamische Therapie blijkt succesvol te kunnen worden toegepast bij hoofd-hals tumoren stadium I, II, en III, blijkt uit een fase II studie uitgevoerd aan het AvL in Amsterdam.

"De behandeling, met metatetrahydroxyfenylchlorine als fotoactieve stof, werd uitgevoerd bij 27 patiënten met 42 gemetasteerde (of multiple primaire) tumoren in het hoofd-halsgebied. Van de tumoren in stadium I genas 85%, het genezingspercentage van uitgebreidere tumoren was 38%

Photodynamic therapy in the treatment of multiple primary tumours in the head and neck, located to the oral cavity and oropharynx.
Copper MP, Triesscheijn M, Tan IB, Ruevekamp MC, Stewart FA. Department of Head and Neck Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands. m.copper@nki.nl

OBJECTIVES: Multiple primary tumours are a common problem in the head and neck cancer patients. Curative surgery or radiotherapy of these tumours can be very mutilating or even impossible. This study aims at evaluating meta-tetrahydroxy-phenyl chlorin-mediated photodynamic therapy for second or multiple primary tumours in the head and neck.

DESIGN: Retrospective study of all patients with second or multiple primary tumours treated by photodynamic therapy over a 10-year period.

SETTING: All patients were treated in the Netherlands Cancer Institute, a tertiary referral centre for the head and neck cancer patients.

PARTICIPANTS: A total of 27 patients with 42 the second or the multiple primary head and neck tumours were treated by photodynamic therapy (0.15 mg/kg meta-tetrahydroxy-phenyl chlorin).

MAIN OUTCOMES MEASURES: Cure rates.

RESULTS: Twenty-eight of 42 tumours were cured (67%). Cure rates for stage I or in situ disease were 85%versus 38% for stage II/III.

CONCLUSIONS: Cure rates for photodynamic therapy of the multiple primary head and neck tumours were lower than previously described for first primaries, but were still very encouraging for this difficult patient population. The high cure rate obtained in stage I multiple primaries emphasises the importance of a meticulous follow-up of patients treated for the head and neck cancer to detect new tumours at a curable stage.

PMID: 17550506 [PubMed - in process]


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