1 december 2011: als u het volledige studierapport wilt lezen van onderstaande studie dan kunt u hier klikken en tegen betaling kunt u dan dit inzien.

5 januari 2005: Bron: J Photochem Photobiol B. 2005 Jan 14;78(1):1-6.

14 januari a.s. verschijnt in het tijdschrift J Photochem Photobiol B. 2005 een overzichtsartikel van PDT - Photodynamische Therapie bij huidkanker en met verschillende soorten fotosensitizers. We hebben tot nu toe alleen het abstract van deze studie kunnen krijgen maar hopen na publicatie het volledige artikel te plaatsen. Dat PDT - PhotodynamischeTherapie een effectieve en mooie manier van opereren is wordt steeds duidelijker. Ook bij andere kankersoorten en niet alleen bij oppervlakkig liggende tumoren.

A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin.

Calzavara-Pinton PG, Venturini M, Sala R. Department of Dermatology, Azienda Spedali Civili, P.le Spedali Civili 1, 25123 Brescia, Italy.

Photodynamic therapy (PDT) is a two-step procedure, involving the topical or systemic administration of a photosensitizer followed by selective illumination of the target lesion with visible light, which triggers the oxidative photodamage and subsequent cell death within the target area. In dermatology, PDT has proven to be a useful treatment for a variety of malignant tumors and selected inflammatory diseases. In addition, PDT of several infective viral or bacterial skin diseases has been investigated. These investigations grew out of the positive findings of studies of another important use of PDT: that of disinfection of blood products. Up to now, little has been published concerning the application of PDT to fungi, probably due to the fact that research funding has been mainly directed towards blood disinfection, and these pathogens show a low risk of transfusion transmission. However, preliminary findings have demonstrated that dermatophytes and yeasts can be effectively sensitized in vitro by administering photosensitizers belonging to four chemical groups: phenothiazine dyes, porphyrins and phthalocyanines, as well as aminolevulinic acid, which, while not a photosensitizer in itself, is effectively metabolized into protoporphyrin IX. Besides efficacy, PDT has shown other benefits. First, the sensitizers used are highly selective, i.e., fungi were killed at combinations of drug and light doses much lower than that needed for a similar effect on keratinocytes. Second, all investigated photosensitizers lack genotoxic and mutagenic activity. Finally, the hazard of selection of drug resistant fungal strains was never reported. This paper intends to provide a comprehensive overview of investigative studies about the effects of PDT on yeasts and dermatophytes, and bring attention to this application of PDT which we believe very important in that skin mycosis is so common and PDT is not only cost-effective, but also has the advantages of being highly selective and avoiding the occurrence of drug resistant strains.

PMID: 15629243 [PubMed - in process]


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1 Reactie op "Huidkanker: PDT - Photodynamische therapie ook effectief bij vormen van huidkanker waarbij een bacteriële infectie de oorzaak is. Artikel update 1 december 2011"

  • Elizabeth van Gilst :
    Alle artikelen met zorg gelezen maar waarom als het in grote mate wordt toegepast is de behandeling zo duur en straks niet meer vergoed! een tube Metvix is 300 euro.

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