2 juni 2005: Bron: Am J Clin Oncol. 2005 Jun;28(3):301-9.

Hoge dosis chemo plus autologe stamcel behoudende behandeling geeft significant betere resultaten op 5-jarige overleving van Ewing sarcoom, blijkt uit langjarige studie. Als er bij de eerste diagnose al uitzaaiïngen op afstand of povere reactie op eerder uitgeprobeerde behandelingen waren lijkt dit de prognose van aanslaan te voorspellen. Klik op bovenstaande link voor huidige stand van zaken voor met name stamceltransplantatie en immuuntherapie

Am J Clin Oncol. 2005 Jun;28(3):301-9

Long-term follow up of high-dose chemotherapy with autologous stem cell rescue in adults with Ewing tumor. Laurence V, Pierga JY, Barthier S, Babinet A, Alapetite C, Palangie T, de Pinieux G, Anract P, Pouillart P. Department of Medical Oncology, Institut Curie, Paris, France. Ewing tumors remain of poor prognosis, with 5-year overall survival of 55% to 65% in localized patients and not exceeding 25% in primarily metastatic disease. Several reports, mainly in children, have reported that some patients with poor-risk Ewing tumors may benefit from high-dose chemotherapy (HDCT) with autologous stem cell rescue. This retrospective study analyzed 46 patients treated in our institution between 1987 and 2000 for localized or primary metastatic Ewing tumors by HDCT followed by stem cell rescue. Median follow up was 7.1 years. Median age was 21 years (range, 15-46 years). Twenty-two percent of patients had metastases at diagnosis. The tumor site was axial in 56% of patients. Median tumor size was 9.5 cm. The treatment regimen consisted of induction chemotherapy, local treatment, maintenance chemotherapy, and consolidation HDCT based on alkylating agents. No toxic death was observed in the intensive therapy phase. Five-year overall survival and progression-free survival were 63 +/- 7.7% and 47 +/- 7.6%, respectively. Pejorative prognostic factors in this population were metastases at diagnosis (5-year overall survival 34% vs.71%, P = 0.017) and poor pathologic response (5-year overall survival 44% vs.77%, P = 0.03). This retrospective study shows a high long-term survival rate with high-dose chemotherapy in adults. PMID: 15923805 [PubMed - in process]


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