10 januari 2005: Bron: Reuters - Medscape: Pediatr Blood Cancer 2005;44:1-8.

Nieuwe studie, gepubliceerd in medisch tijdschrift Pediatric Blood and Cancer bewijst dat kinderen die chemo krijgen voor ALL - Acute Lymfatische Leukemie gebaat zijn met aanvullende bepaalde antioxidanten zoals vit. E en A en C. om bijwerkingen te verminderen en effectiviteit van behandeling te vergroten. De studie toont aan dat tijdens de chemokuur de niveaus van bepaalde antioxidanten sterk verlaagd worden en orale aanvulling kan deze kinderen helpen beter de chemokuren te doorstaan.

Antioxidant levels tied to treatment toxicities in ALL
NEW YORK (Reuters Health) - In children with acute lymphoblastic leukemia (ALL), antioxidant levels seem to predict treatment toxicity and quality of life, new study findings suggest.
Cancer outcomes among adults are associated with antioxidant concentrations, Dr. Kara M. Kelly and her colleagues note in their report in the journal Pediatric Blood and Cancer, published online December 27th. However, little is known about antioxidant concentrations in children with cancer, although previous studies showed increased free-radical production during ALL chemotherapy.
They therefore prospectively followed 103 children newly diagnosed with ALL, measuring antioxidant levels, antioxidant capacity as determined by the Oxygen Radical Absorbance Capacity (ORAC) assay, and oxidative damage, as reflected by levels 8-oxodeoxyguanosine (8-oxo-dG), during the first 6 months of treatment.
Overall, the authors report, plasma concentrations of vitamin E decreased over time, while total carotenoids and vitamin A, increased. Vitamin C and 8-oxo-dG increased over the first 6 months, then declined by month 6. ORAC decreased throughout the study, "suggesting that the pool of flavanoids is reduced with initiation of chemotherapy."
"In patients with higher plasma concentrations of vitamin A, E, total carotenoids, ORAC, and 8-oxo-dG there was a beneficial association with fewer dose reductions, fewer infections, improved quality of life, less delay in chemotherapy treatment schedule, reduced toxicity, and fewer days spent in the hospital," Dr. Kelly's group writes.
Although more research is required to clarify the relationships between antioxidants and cancer treatment outcomes, the authors note, the current findings suggest that children with ALL may experience fewer treatment-related side effects by increasing the amount of fruits and vegetables in their diet.
Pediatr Blood Cancer 2005;44:1-8.

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