Abstract
Membrane lipid peroxidation (LPO) induced by hydroxyl (*OH) and ascorbyl (*Asc) radicals and by peroxynitrite (ONOO-) was investigated in asolectin (ASO), egg phosphatidylcholine (PC) and PC/phosphatidic acid mixtures (PC:PA) liposomes and rat liver microsomes (MC). Enthalpy variation (DeltaH) of PC:PA at different molar ratios were obtained by differential scanning calorimetry. It was also evaluated the LPO inhibition by quercetin, melatonin and Vitamin B6. The oxidant effect power follows the order *OH approximately *Asc > ONOO- on PC and MC; whilst on ASO liposomes, it follows *Asc > *OH approximately ONOO-. Increasing amounts of PA in PC liposomes resulted in lower levels of LPO. The DeltaH values indicate a more ordered membrane arrangement as a function of PA amount. The results were discussed in order to provide a complete view involving the influence of membranes, oxidants and antioxidants intrinsic behavior on the LPO dynamics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry*
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Antioxidants / metabolism
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Calorimetry, Differential Scanning
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Egg Yolk / chemistry
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Free Radicals / chemistry
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Free Radicals / metabolism
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Lipid Bilayers / chemistry*
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Lipid Bilayers / metabolism
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Lipid Peroxidation / physiology
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Liposomes / chemistry
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Liposomes / metabolism
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Membrane Lipids / chemistry*
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Membrane Lipids / metabolism
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Microsomes, Liver / chemistry
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Microsomes, Liver / metabolism
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Phosphatidic Acids / chemistry
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Phosphatidylcholines / chemistry
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Phospholipids / chemistry
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Rats
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Reactive Nitrogen Species / chemistry*
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Reactive Nitrogen Species / metabolism
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Reactive Oxygen Species / chemistry*
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Reactive Oxygen Species / metabolism
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Structure-Activity Relationship
Substances
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Antioxidants
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Free Radicals
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Lipid Bilayers
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Liposomes
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Membrane Lipids
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Phosphatidic Acids
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Phosphatidylcholines
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Phospholipids
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Reactive Nitrogen Species
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Reactive Oxygen Species
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asolectin