23 april 2010: bron: Am J Clin Nutr.2010; 0: ajcn.2009.28691v1-ajcn.28691

Mensen die veel voedsel eten rijk aan vitamine K2 - menaquinones verkleinen daarmee met 28% het risico op het krijgen van kanker blijkt uit een postpectieve studie aan de universiteit van Heidelberg ( EPIC - Heidelberg) bij 24340 deelnemers. Vooral longkanker en prostaatkanker springen eruit aldus de onderzoekers. Vitamine K2 - menaquinones zit o.a. veel in kaas. Ook in vlees maar volgens de onderzoekers had vitamine K2 binnen gekregen door eten van vlees niet een preventief effect.  

In dezelfde studie werd geen assiociatie gevonden voor de inname van vitamine K1 - phylloquinone.  Hier achtereenvolgens het abstract van de algemene studie en het abstract van de studie welke suggereert dat vitamine K2 - menaquinones preventief werkt bij prostaatkanker..

Am J Clin Nutr (March 24, 2010). doi:10.3945/ajcn.2009.28691

Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)1,2,3

Katharina Nimptsch, Sabine Rohrmann, Rudolf Kaaks and Jakob Linseisen

1 From the Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany (KN SR RKJL); the Department of Nutrition Harvard School of Public Health Boston MA (KN);the Institute of Epidemiology Helmholtz Zentrum München Neuherberg Germany (JL).

2 Supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (contract no 513943). 3 Address correspondence to J Linseisen, Institute of Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Ingolstädter Landstr. 1, D-85746 Neuherberg, Germany. E-mail: j.linseisen@helmholtz-muenchen.de .


Background: Anticarcinogenic activities of vitamin K have been observed in animal and cell studies.

Objective: On the basis of the growth inhibitory effects of vitamin K as observed in a variety of cancer cell lines, we hypothesized that dietary intake of phylloquinone (vitamin K1) and menaquinones (vitamin K2) may be associated with overall cancer incidence and mortality.

Design: In the prospective EPIC-Heidelberg (European Prospective Investigation into Cancer and Nutrition–Heidelberg) cohort study, 24,340 participants aged 35–64 y and free of cancer at enrollment (1994–1998) were actively followed up for cancer incidence and mortality through 2008. Dietary vitamin K intake was estimated from food-frequency questionnaires completed at baseline by using HPLC-based food-composition data. Multivariate-adjusted hazard ratios (HRs) and 95% CIs were estimated by using Cox proportional hazards models.

Results: During a median follow-up time of >10 y, 1755 incident cancer cases occurred, of which 458 were fatal. Dietary intake of menaquinones was nonsignificantly inversely associated with overall cancer incidence (HR for the highest compared with the lowest quartile: 0.86; 95% CI: 0.73, 1.01; P for trend = 0.08), and the association was stronger for cancer mortality (HR: 0.72; 95% CI: 0.53, 0.98; P for trend = 0.03). Cancer risk reduction with increasing intake of menaquinones was more pronounced in men than in women, mainly driven by significant inverse associations with prostate (P for trend = 0.03) and lung cancer (P for trend = 0.002). We found no association with phylloquinone intake.

Conclusion: These findings suggest that dietary intake of menaquinones, which is highly determined by the consumption of cheese, is associated with a reduced risk of incident and fatal cancer.

Received for publication September 17, 2009. Accepted for publication February 28, 2010.

Hier abstract van het effect van vtamine K2 - menaquinones bij prostaatkanker. Voor het volledige studierapport klik hier

Am J Clin Nutr. 2008 Apr;87(4):985-92.

Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg).

Nimptsch K, Rohrmann S, Linseisen J.

Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.


BACKGROUND: Anticarcinogenic activities of vitamin K have been observed in various cancer cell lines, including prostate cancer cells. Epidemiologic studies linking dietary intake of vitamin K with the development of prostate cancer have not yet been conducted.

OBJECTIVE: We evaluated the association between dietary intake of phylloquinone (vitamin K1) and menaquinones (vitamin K2) and total and advanced prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. DESIGN: At baseline, habitual dietary intake was assessed by means of a food-frequency questionnaire. Dietary intake of phylloquinone and menaquinones (MK-4-14) was estimated by using previously published HPLC-based food-content data. Multivariate-adjusted relative risks of total and advanced prostate cancer in relation to intakes of phylloquinone and menaquinones were calculated in 11 319 men by means of Cox proportional hazards regression.

RESULTS: During a mean follow-up time of 8.6 y, 268 incident cases of prostate cancer, including 113 advanced cases, were identified. We observed a nonsignificant inverse association between total prostate cancer and total menaquinone intake [multivariate relative risk (highest compared with lowest quartile): 0.65; 95% CI: 0.39, 1.06]. The association was stronger for advanced prostate cancer (0.37; 0.16, 0.88; P for trend = 0.03). Menaquinones from dairy products had a stronger inverse association with advanced prostate cancer than did menaquinones from meat. Phylloquinone intake was unrelated to prostate cancer incidence (1.02; 0.70, 1.48).

CONCLUSIONS: Our results suggest an inverse association between the intake of menaquinones, but not that of phylloquinone, and prostate cancer. Further studies of dietary vitamin K and prostate cancer are warranted.

PMID: 18400723 [PubMed - indexed for MEDLINE]Free Article 

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