Abstract
Primary explants of human malignant melanoma were utilized in the preparation of oncolysates by Newcastle disease virus. The concentrated lysate, administered parenterally, was employed in an effort to augment antitumor immunologic responses in patients with metastatic melanoma. Observed cellular changes suggested a benefit, but humoral antibody measurements were not impressive.
MeSH terms
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Antigens, Neoplasm / administration & dosage
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Antigens, Neoplasm / isolation & purification
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Cytotoxicity Tests, Immunologic
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Humans
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Immunity
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Immunotherapy
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Leukocyte Count
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Lymphocytes / immunology
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Melanoma / blood
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Melanoma / immunology
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Melanoma / therapy*
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Newcastle disease virus*
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Skin Neoplasms / immunology
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Skin Neoplasms / therapy*
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Skin Tests
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T-Lymphocytes
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Viruses*