Mocht u kanker-actueel de moeite waard vinden en ons willen ondersteunen om kanker-actueel online te houden dan kunt u ons machtigen voor een periodieke donatie via donaties: https://kanker-actueel.nl/NL/donaties.html of doneer al of niet anoniem op - rekeningnummer NL79 RABO 0372931138 t.n.v. Stichting Gezondheid Actueel in Amersfoort. Onze IBANcode is NL79 RABO 0372 9311 38   
Elk bedrag is welkom. En we zijn een ANBI instelling dus uw donatie of gift is in principe aftrekbaar voor de belasting.

En als donateur kunt u ook korting krijgen bij verschillende bedrijven: 

https://kanker-actueel.nl/NL/voordelen-van-ops-lidmaatschap-op-een-rijtje-gezet-inclusief-hoe-het-kookboek-en-de-recepten-op-basis-van-uitgangspunten-van-houtsmullerdieet-te-downloaden-enof-in-te-zien.html

3 februari 2017: Bron: ASCO en Journal of Clinical Oncology

Op 1 februari 2017 is online een overzichtsrapport verschenen: Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology die de belangrijkste studies bespreekt die afgelopen jaar werden gepubliceerd. En voor het tweede jaar op rij wordt immuuntherapie genoemd als de belangrijkste ontwikkeling.

Vooral de anti-PD medicijn studies (checkpoint remmers) geven steeds goede hoopvolle resultaten bij nagenoeg alle vormen van kanker:

Checkpoint remmers beeld

Fig 2. Immune checkpoint inhibitors: releasing the brakes on the immune system. MHC, major histocompatibility complex; PD-1, programmed death 1; PD-L1, programmed death ligand-1; TCR, T-cell receptor.

Maar ook gerichte medicijnen op bepaalde DNA mutaties en receptorenexpressie spelen grote rol in de nieuwste behandelingen van kanker. Ook preventie en screeening via ook o.a. bloedmonsters krijgen veel aandacht in dit rapport:

A range of other important advances and trends are featured in Clinical Cancer Advances:

  • Precision medicine: Last year brought approvals of new treatments targeting molecules important in the growth of certain types of kidney, lung, breast, and blood cancer.
  • Liquid biopsies: The first test for circulating plasma tumor DNA was approved by the FDA in 2016 for certain patients with lung cancer. This new technology allows physicians to assess key cancer-driving tumor mutations through a simple blood draw, as opposed to invasive tissue biopsies, which in turn facilitates selection of optimal treatment and monitoring changes in the status of the tumor over time.
  • New tools help bridge gaps between patients and physicians: The report highlights a Web-based tool for self-monitoring symptoms that immediately alerts the cancer care team when patients report that a symptom is worsening. In addition, education and patient navigation programs demonstrate ways to increase treatment adherence.

“To conquer cancer, we must conduct research across the cancer care continuum, from screening to new treatments and strategies that help ease treatment side effects,” said Harold J. Burstein, MD, PhD, FASCO, Co-Executive Editor of Clinical Cancer Advances.

Het studierapport isd zo uitgebreid, maar ook veel van wat er in besprken wordt is ook wel op kanker-actueel te vinden dat ik maar niet verder vertaal.

Het studierapport: Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology is op verschillende manieren te bekijken. Op de website van de Journal of Clinical Oncology is het volledige rapport gratis in te zien.

Via ASCO is het rapport als flipbook in te bladeren.

Tot slot als u het studierapport wilt hebben in een PDF document kunt u ons een mailtje sturen: redactie@kanker-actueel.nl  en sturen we het u digitaal toe.

Hier de inleiding tot het rapport met daaronder de referentielijst behorend bij dit studierapport:

A growing number of patients with cancer are benefiting from research advances in immunotherapy, leading ASCO to name immunotherapy as the Society's Advance of the Year for a second year in a row. Clinical Cancer Advances 2017 highlights the expanding role of immunotherapy. Evolving research findings are providing new insights on how to get optimal results from these relatively new treatments.

Source: DOI: 10.1200/JCO.2016.71.5292 Journal of Clinical Oncology - published online before print February 1, 2017

Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

*, , †, †, †, †, †, †, †, †, †, †, †, †, †, †, †, ‡, †, †, †, †, and *Harold J. Burstein and Steven G. DuBois, Dana-Farber Cancer Institute; Rebecca A. Miksad and Nadine Tung, Beth Israel Deaconess Medical Center; Lori J. Wirth and Don S. Dizon, Massachusetts General Hospital, Boston, MA; Lada Krilov and Richard L. Schilsky, American Society of Clinical Oncology, Alexandria; Jeanny B. Aragon-Ching, Inova Schar Cancer Institute, Fairfax, VA; E. Gabriela Chiorean, University of Washington, Seattle, WA; Warren Allen Chow, City of Hope, Duarte, CA; John Frederick De Groot and John Heymach, University of Texas MD Anderson Cancer Center, Houston, TX; Steven Michael Devine, Ohio State University, Columbus; Nathan A. Pennell, Cleveland Clinic, Cleveland, OH; Wafik S. El-Deiry, Fox Chase Cancer Center; Joshua Adam Jones, University of Pennsylvania Health Systems; Lynn Mara Schuchter, University of Pennsylvania, Philadelphia, PA; Andrew S. Epstein, Memorial Sloan Kettering Cancer Center, New York, NY; Deborah K. Mayer, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill; Karen Marie Winkfield, Wake Forest Baptist Medical Center, Winston-Salem, NC; Michael S. Sabel, University of Michigan, Ann Arbor, MI; and Nancy N. Baxter, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada.

Abstract

I am pleased to present Clinical Cancer Advances 2017, which highlights the most promising advances in patient-oriented cancer research over the past year. The report gives us an opportunity to reflect on what an exciting time it is for cancer research and how swiftly our understanding of cancer has improved.

One year ago, the White House announced the national Cancer Moonshot program to accelerate progress against cancer. This shared vision of progress has reinvigorated the research community, identified new areas of scientific collaboration, and raised our ambitions regarding what may be possible beyond the progress we have already made.

When I entered the field 35 years ago, I could not have imagined where we would be today. We can now detect cancer earlier, target treatments more effectively, and manage adverse effects more effectively to enable patients to live better, more fulfilling lives. Today, two of three people with cancer live at least 5 years after diagnosis, up from roughly one of two in the 1970s.

This progress has resulted from decades of incremental advances that have collectively expanded our understanding of the molecular underpinnings of cancer. There is no better current example of this than ASCO’s 2017 Advance of the Year: Immunotherapy 2.0.

Over the last year, there has been a wave of new successes with immunotherapy. Research has proven this approach can be effective against a wide range of hard-to-treat advanced cancers previously considered intractable. Researchers are now working to identify biologic markers that can help increase the effectiveness of treatment and determine who is most likely to benefit from immunotherapy. This knowledge will enable oncologists to make evidence-based decisions so as many patients as possible might benefit from this new type of treatment.

Each successive advance builds on the previous hard work of generations of basic, translational, and clinical cancer researchers. Importantly, the advances described in this report would not have been possible without the individuals who volunteered to participate in clinical trials as part of their treatment.

To turn the promising vision of a cancer moonshot into meaningful advances, we need sustained, robust federal funding for continued research and innovation. Approximately 30% of the research highlighted in this report was funded, at least in part, through federal dollars appropriated to the National Institutes of Health or the National Cancer Institute. Without this federal investment—unique internationally in scale, duration, and impact for decades—I fear we may lose the forward momentum needed to further the progress we see highlighted in this report.

Federal lawmakers can further fuel progress by advancing initiatives that facilitate the use of big data to achieve the common good of high-quality care for all patients. Such programs, like ASCO’s CancerLinQ, will rapidly increase the pace of progress and dramatically expand the reach of treatment advances to the millions of patients who are living with cancer today or who will do so in the future. This investment will yield medical, scientific, economic, and societal benefits for years to come.

Much work still lies ahead. Many questions remain about how cancer develops and spreads and how best to treat it. As you read through Clinical Cancer Advances 2017, I hope you are as inspired as I am by the gains the clinical cancer research community has made over the past year and by the promise of a new era of advances just over the horizon.

Daniel F Hayes, MD, FASCO, FACP

ASCO President, 2016 to 2017

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