24 september 2011: Bron: BMC Cancer. 2011 Jun 24;11:269.

Dat lijnzaad een rol kan spelen in een behandeling van kanker heeft o.a. dr. Budwig altijd gezegd en er zijn ook studies die bewijzen dat loijnzaad van waarde kan zijn in een behandeling van bv. borstkanker. Nu hebben onderzoekers in Amerika aangetoond in een studie met muizen dat verse lijnzaad de schade van bestralen kan voorkomen en zelfs kan herstellen. Het is weliswaar slechts een dierstudie maar wie de studieresultaten bekijkt (volledige studierapport is gratis beschikbaar als u hier klikt) ziet toch opmerkelijke resultaten van elke dag een beetje vers lijnzaad eten. De studie is gerandomiseerd uitgevoerd en dus vergeleken met een controlegroep muizen die geen lijnzaad kreeg. Hier het abstract van de studie, maar lees vooral ook het volledige studierapport

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice

BMC Cancer. 2011 Jun 24;11:269.

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice.

Source

Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. melpo@mail.med.upenn.edu

Abstract

BACKGROUND:

Flaxseed (FS) is a dietary supplement known for its antioxidant and anti-inflammatory properties. Radiation exposure of lung tissues occurs either when given therapeutically to treat intrathoracic malignancies or incidentally, such as in the case of exposure from inhaled radioisotopes released after the detonation of a radiological dispersion devise (RDD). Such exposure is associated with pulmonary inflammation, oxidative tissue damage and irreversible lung fibrosis. We previously reported that dietary FS prevents pneumonopathy in a rodent model of thoracic X-ray radiation therapy (XRT). However, flaxseed's therapeutic usefulness in mitigating radiation effects post-exposure has never been evaluated.

METHODS:

We evaluated the effects of a 10%FS or isocaloric control diet given to mice (C57/BL6) in 2 separate experiments (n = 15-25 mice/group) on 0, 2, 4, 6 weeks post a single dose 13.5 Gy thoracic XRT and compared it to an established radiation-protective diet given preventively, starting at 3 weeks prior to XRT. Lungs were evaluated four months post-XRT for blood oxygenation levels, inflammation and fibrosis.

RESULTS:

Irradiated mice fed a 0%FS diet had a 4-month survival rate of 40% as compared to 70-88% survival in irradiated FS-fed mouse groups. Additionally, all irradiated FS-fed mice had decreased fibrosis compared to those fed 0%FS. Lung OH-Proline content ranged from 96.5 ± 7.1 to 110.2 ± 7.7 μg/ml (Mean ± SEM) in all irradiated FS-fed mouse groups, as compared to 138 ± 10.8 μg/ml for mice on 0%FS. Concomitantly, bronchoalveolar lavage (BAL) protein and weight loss associated with radiation cachexia was significantly decreased in all FS-fed groups. Inflammatory cell influx to lungs also decreased significantly except when FS diet was delayed by 4 and 6 weeks post XRT. All FS-fed mice (irradiated or not), maintained a higher blood oxygenation level as compared to mice on 0%FS. Similarly, multiplex cytokine analysis in the BAL fluid revealed a significant decrease of specific inflammatory cytokines in FS-fed mice.

CONCLUSIONS:

Dietary FS given post-XRT mitigates radiation effects by decreasing pulmonary fibrosis, inflammation, cytokine secretion and lung damage while enhancing mouse survival. Dietary supplementation of FS may be a useful adjuvant treatment mitigating adverse effects of radiation in individuals exposed to inhaled radioisotopes or incidental radiation.

PMID:
21702963
[PubMed - in process]
PMCID: PMC3146937

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