3 april 2012: onderstaand artikel uit 2001 was een van de eerste studies die aantoonde dat lycopeen mogelijk DNA schade repareert en invloed heeft op ontstaan en progressie van prostaatkanker. Als u hier klikt kunt u het volledige studierapport gratis inzien van een recente meta analyse over hoe dan precies lycopeen zou werken. De onderzoekers weten dat nog niet zeker maar er zijn aanwijzingen dat lycopeen invloed heeft op het 'DNA' van de prostaatkankercel. Voor medici en wetenschappers een o.i. interessante studie. Voor leken bevestigt deze studie de goede werking van lycopeen.

Global gene expression analysis revealed no significant individual genes that were associated with high intake of fish or tomato at baseline or after 3 months of supplementation with lycopene or fish oil. However, exploratory pathway analyses of rank-ordered genes (based on p-values not corrected for multiple comparisons) revealed the modulation of androgen and estrogen metabolism in men who routinely consumed more fish (p = 0.029) and tomato (p = 0.008) compared to men who ate less. In addition, modulation of arachidonic acid metabolism (p = 0.01) was observed after 3 months of fish oil supplementation compared with the placebo group; and modulation of nuclear factor (erythroid derived-2) factor 2 or Nrf2-mediated oxidative stress response for either supplement versus placebo (fish oil: p = 0.01, lycopene: p = 0.001).
We did not detect significant individual genes associated with dietary intake and supplementation of lycopene and fish oil. However, exploratory analyses revealed candidate in vivo pathways that may be modulated by these micronutrients.


Tomato Sauce Consumption Decreases DNA Damage in Prostate Cancer Patients

NEW YORK (Reuters Health) Dec 18 - Men with prostate cancer given a short-term tomato sauce-based diet had reduced levels of prostate-specific antigen (PSA), and significantly lower prostatic tissue oxidative DNA damage, according to a report in the Journal of the National Cancer Institute for December 19.

Dr. Phyllis E. Bowen from the University of Illinois at Chicago, and colleagues note that "the risk of prostate cancer is lower in men reporting higher consumption of tomato products," which prompted the researchers to investigate the effect of tomato intake in men already diagnosed with prostate cancer.

They placed 32 men with localized prostate adenocarcinoma, who were to undergo radical prostatectomy, on a 3 week diet of pasta with tomato sauce that included a mean of 26.8 mg of lycopene per day. The researchers measured PSA levels before and after the diet and assessed oxidative DNA damage in resected prostate samples.

The diet significantly increased both serum (1.97-fold) and prostate lycopene concentrations (2.92-fold, p < 0.001 for both), and was associated with a 21.3% reduction in leukocyte oxidative DNA damage (p = 0.005). Serum PSA levels also dropped 17.5% from a mean of 10.9 ng/mL before the diet to 8.7 ng/mL after the diet, Dr. Bowen's team reports.

Also, oxidative DNA damage in prostate tissue removed at operation was 28.3% less than in tissue samples from seven randomly selected prostate cancer patients, the researchers found.

Dr. Bowen and colleagues conclude that "these data indicate a possible role for a tomato sauce constituent, possible lycopene, in the treatment of prostate cancer and warrant further testing with a larger sample of patients, including a control group."

J Natl Cancer Inst 2001;93:1872-1879.

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