30 april 2024: zie ook dit artikel: https://kanker-actueel.nl/ziekte-van-parkinson-prasinezumab-een-monoklonaal-antilichaam-dat-alfa-synucleine-bindt-vertraagt-sterk-de-progressie-van-de-ziekte-van-parkinson-in-vergelijking-met-patienten-die-beste-zorg-kregen.html

21 april 2012: ik heb enkele veranderingen en aanpassingen gemaakt in de links in onderstaand artikel en onderaan een referentielijst toegevoegd van studies gedaan met Q-10

16 oktober 2002: Bron: Nature

Q-10, een natuurlijk voedingssupplement zorgt voor een grote afremming van het ziekteproces van de ziekte van Parkinson (40% verschil met controlegroep), blijkt uit een gerandomiseerde driejarige studie onder 80 patiënten aan de universiteit van Californië. Nu zult u zeggen maar dat is nog geen kanker, maar Q-10 wordt algemeen beschouwd als een sterke anti-oxidant, een kankerremmer die zowel preventief als aanvullend in een behandeling voor een positief effect zorgt. Lees enkele studies met Q-10 op pagina literatuurlijst van arts-bioloog Drs. E. Valstar of lees het referentieschema van de positieve effecten van bepaalde voedingsupplementen waaronder Q-10 in een behandeling van kanker. En de ziekte van Parkinson wordt ook algemeen gezien als een degeneratieve ziekte zoals ook kanker. Hieronder het persbericht over Q-10 bij de ziekte van Parkinson zoals gemeld door Nature. Valstar zegt: Overigens herhaal ik de waarschuwing zoals ook Nature doet, neem niet zonder consult zomaar een bepaalde hoeveelheid Q-10, maar consulteer altijd een orthomoleculaire arts voor de juiste dosering en eventuele contra-indicaties. Adresgegevens van goed gekwalificeerde orthomoleculaire artsen staan op pagina nuttige adressen.

 

d.d. 15 oktober 2002, bron Nature: An over-the-counter dietary pill may slow the brain deterioration seen in Parkinson's disease, researchers have announced1. But patients are being warned not to head for the drugstore just yet.

A dose of the supplement, coenzyme Q10, stalls the onset of some of the movement problems that accompany the disorder, the American Neurological Association meeting will hear today. "It didn't stop progression but it did reduce it," says Clifford Shults of the University of California, San Diego, who led the three-year pilot study.

Existing treatments for the disease relieve the symptoms but do not treat the cause: the breakdown of the nerves in the brain that make the neurotransmitter dopamine. Finding a drug that prevents this decay "is at the centre of everyone's radar screen", says Bill Langston of the Parkinson's Institute in Sunnyvale, California.

The findings of Shults's team are some of the first evidence for such a 'neuro-protective' agent. But experts stress that another large-scale trial will be required before doctors can start recommending daily supplements. "It would be premature to suggest to patients that they should take high levels of Q10," says Shults.

Because the enzyme is already available in drugstores as a dietary supplement, there are concerns that patients might start popping pills prematurely. "An unsuspecting public will be encouraged to buy it without any scientific evidence," warns Parkinson's researcher Warren Olanow of Mount Sinai School of Medicine in New York.

Parkinson's affects roughly a million people in the United States, causing tremors and slowing movement.

Q tip

Some Parkinson's patients have low levels of coenzyme Q10 and scientists hypothesized that this may contribute to nerve degeneration, prompting the trial. The enzyme normally dwells in mitochondria, the power generators of cells. It also acts as an antioxidant, stopping the production of damaging molecules called free radicals.

Shults and his colleagues treated 80 patients in their early 60s who showed initial signs of the disease. The patients received either a daily placebo or 300, 600 or 1,200 milligrams of coenzyme Q10, and were monitored over 16 months or until their symptoms required treatment with conventional dopamine therapy.

The condition of patients taking 1,200 milligrams worsened 40% less over time than that of patients taking the placebo, according to a scale that measures the severity of Parkinson's symptoms. For example, the patients might not need help in dressing themselves, explains Shults. Those taking the lower doses were helped to a lesser extent.

But some experts have voiced concerns over the trial. Looking at symptoms is only an indirect measure of nerve-cell damage, points out Olanow. The enzyme could simply be relieving the symptoms rather than preventing the disease. The trial did not actually delay the time at which patients needed treatment.

The US National Institutes of Health are currently deciding which potential neuro-protective agents to fund in large-scale clinical trials. Other potential treatments include anti-inflammatory drugs. "The field is flush with possible candidates," says Olanow. "The problem is to prove they work."


References
Shults, C. et al. Effects of coenzyme Q10 in early Parkinson disease. Archives of Neurology, 59, 1541 - 1550, (2002). |Article|

 

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