Aan dit artikel is enkele uren gewerkt. Opzoeken, vertalen, plaatsen enz. Als u ons wilt ondersteunen dan kan dat via een al of niet anonieme donatie. Elk bedrag is welkom hoe klein ook. Klik hier als u ons wilt helpen kanker-actueel online te houden Wij zijn een ANBI organisatie dus uw donatie is in principe aftrekbaar voor de belasting.

24 juni 2012: Bron: ACTA Dermata Venereologica doi: 10.2340/00015555-1358

Melk en melkproducten en voeding met een hoge glycemische index - de snelheid waarmee koolhydraten worden afgebroken en als glucose in het bloed wordt opgenomen, spelen grote rol in de vorming van acne en staan aan de basis van veel immuunziektes als suikerziekte - diabetes 2, maar ook op langere termijn aan de basis van sommige vormen van kanker. (zie verder wat glycemische index betekent bij Wikipedia)
Dit blijkt uit 2 gerandomiseerde studies en onderstreept de rol van een westers voedingspatroon in de pathogenese van acne. Uit deze twee studies blijkt dat acne nagenoeg  afwezig is in de bevolking die eten en drinken volgens een voedingspatroon met voedingstoffen met een lage glycemische lading en weinig of geen koemelk of zuivelproducten gebruiken. Daarmee wordt volgens de onderzoekers bewezen dat een voedingspatroon met een lage glycemische lading gunstige therapeutische effecten kan hebben bij het voorkomen en behandelen  
van acne. Acne moet worden beschouwd als een door de zogeheten mTORC1 gedreven welvaartsziekten, zoals obesitas, diabetes type 2 en kanker en worden veelal veroorzaakt door een westers dieet. Vroege dieetadvisering van tieners met of zonder acne kan helpen bij het verbeteren van acne, maar kan ook op lange termijn schadelijke effecten van een westers voedingspatroon  op meer ernstige door mTORC1 gedreven welvaartsziekten voorkomen, aldus de onderzoekers. Op de website www.glycemische-index.com kunt u staatjes inzien van welke voeding een hoge en welke voeding een lage glycemische lading heeft.

Hier de abstracten van de 2 gerandomiseerde studies. Van 1 studie - Diet in Acne: Further Evidence for the Role of Nutrient Signalling in Acne Pathogenesis - is op de website van Medical Journals het volledige studierapport  gratis in te zien.

Further Evidence for the Role of Nutrient Signalling in Acne Pathogenesis

Bodo C. Melnik

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany

Recent evidence underlines the role of Western diet in the pathogenesis of acne. Acne is absent in populations consuming Palaeolithic diets with low glycaemic load and no consumption of milk or dairy products. Two randomized controlled studies, one of which is presented in this issue of Acta Dermato-Venereologica, have provided evidence for the beneficial therapeutic effects of low glycaemic load diets in acne. Epidemiological evidence confirms that milk consumption has an acne-promoting or acne-aggravating effect. Recent progress in understanding the nutrient-sensitive kinase mammalian target of rapamycin complex 1 (mTORC1) allows a new view of nutrient signalling in acne by both high glycaemic load and increased insulin-, IGF-1-, and leucine signalling due to milk protein consumption. Acne should be regarded as an mTORC1-driven disease of civilization, like obesity, type 2 diabetes and cancer induced by Western diet. Early dietary counselling of teenage acne patients is thus a great opportunity for dermatology, which will not only help to improve acne but may reduce the long-term adverse effects of Western diet on more serious mTORC1-driven diseases of civilization. Key words: acne; diet; glycaemic load; milk; mTORC1.

(Accepted February 29, 2012.)

Acta Derm Venereol 2012; 92: XX–XX.

Bodo C. Melnik, Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Sedanstrasse 115, DE-49090 Osnabrück, Germany. E-mail: melnik@t-online.de 

REFERENCES

  1. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris. A disease of Western civilization. Arch Dermatol 2002; 138: 1584–1590. [CrossRef]
  2. Smith RN, Mann NJ, Braue A, Mäkeläinen H, Varigos GA. The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial. J Am Acad Dermatol 2007; 57: 247–256. [CrossRef]
  3. Kwon HH, Youn JY, Hong JS, Jung JY, Park MS, Suh DH. The clinical and histological effect of low glycemic load diet in the treatment of acne vulgaris in Korean patients: a randomized, controlled trial. Acta Derm Venereol 2012; 92: yy–zz. [CrossRef]
  4. Smith TM, Gilliland K, Clawson GA, Thiboutot D. IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway. J Invest Dermatol 2008; 128: 1286–1293. [CrossRef]
  5. Melnik BC, Schmitz G. Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol 2009; 18: 833–841. [CrossRef]
  6. Bowe WP, Joshi SS, Shalita AR. Diet and acne. J Am Acad Dermatol 2010; 63: 124–141. [CrossRef]
  7. Rich-Edwards JW, Ganmaa D, Pollak MN, Nakamoto EK, Kleinman K, Tserendolgor, et al. Milk consumption and the prepubertal somatotropic axis. Nutr J 2007; 6: 28. [CrossRef]
  8. Norat T, Dossus L, Rinaldi S, Overvad K, Grønbaek H, Tjønneland A, et al. Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women. Eur J Clin Nutr 2007; 6: 91–98. [CrossRef]
  9. Crowe FL, Key TJ, Allen NE Appleby PN, Roddam A, Overvad K, et al. The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 2009; 18:1333–1340. [CrossRef]
  10. Adebamowo CA, Spiegelman D, Danby FW, Frazier AL, Willett WC, Holmes MD. High school dietary intake and acne. J Am Acad Dermatol 2005; 52: 207–211. [CrossRef]
  11. Adebamowo CA, Spiegelman D, Berkey CS, Danby FW, Rockett HH, Colditz GA, et al. Milk consumption and acne in adolescent girls. Dermatology Online J 2006; 12: 1–12. [CrossRef]
  12. Adebamowo CA, Spiegelman D, Berkey CS, Danby FW, Rockett HH, Colditz GA, et al. Milk consumption and acne in teenaged boys. J Am Acad Dermatol 2008; 58: 787–793. [CrossRef]
  13. Melnik BC. Evidence for acne-promoting effects of milk and other insulinotropic dairy products. Nestle Nutr Workshop Ser Pediatr Program 2011; 67: 131–145. [CrossRef]
  14. Inoki K, Ouyang H, Li Y, Guan KL. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 2005; 69: 79–100. [CrossRef]
  15. Melnik BC. The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action. G Ital Dermatol Venereol 2010; 145: 559–571. [CrossRef]
  16. Fan W, Yanase T, Morinaga H, Okabe T, Nomura M, Daitoku H, et al. Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of FoxO1 with androgen receptor. J Biol Chem 2007; 282: 7329–7338. [CrossRef]
  17. Ma Q, Fu W, Li P, Nicosia SV, Jenster G, Zhang X, Bai W. FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment. Mol Endocrinol 2009; 23: 213–225. [CrossRef]
  18. Wang Q, Bailey CG, Ng C, Tiffen J, Thoeng A, Minhas V, et al. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Res 2011; 71: 7525–7536. [CrossRef]
  19. Kim J, Guan KL. Amino acid signaling in TOR activation. Annu Rev Biochem 2011; 80: 1001–1032. [CrossRef]
  20. Boura-Halfon S, Zick Y. Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 2009; 296: E581–E591. [CrossRef]
  21. Chen W, Obermayer-Pietsch B, Hong JB, Melnik BC, Yamasaki O, Dessinioti C, et al. Acne-associated syndromes: models for better understanding of acne pathogenesis. J Eur Acad Dermatol Venereol 2011; 25: 637–466. [CrossRef]
  22. Hoppe C, Mølgaard C, Vaag A, Barkholt V, Michaelsen KF. High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys. Eur J Clin Nutr 2005; 59: 393–398. [CrossRef]
  23. Porstmann T, Santos CR, Lewis C, Griffiths B, Schulze A. A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. Biochem Soc Trans 2009; 37: 278–283. [CrossRef]
  24. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 2011; 146: 408–420. [CrossRef]
  25. Ben-Amitai D, Laron Z. Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne. J Eur Acad Dermatol Venereol 2011; 25: 950–954. [CrossRef]
  26. Melnik BC, John SM, Schmitz G. Over-stimulation of insulin/IGF-1 signaling by Western diet may promote diseases of civilization: lessons learnt from Laron syndrome. Nutr Metab (Lond) 2011; 8:41. [CrossRef]
  27. Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006; 441: 424–430. [CrossRef]
  28. Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Rev Mol Cell Biol 2011; 12: 21–35. [CrossRef]
  29. Allen NE, Key TJ, Appleby PN, Travis RC, Roddam AW, Tjønneland A, et al. Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 2008; 98: 1574–1581. [CrossRef]
  30. Torfadottir JE, Steingrimsdottir L, Mucci L, Aspelund T, Kasperzyk JL, Olafsson O, et al. Milk intake in early life and risk of advanced prostate cancer. Am J Epidemiol 2012; 175: 144–153. [CrossRef]
  31. Tate PL, Bibb R, Larcom LL. Milk stimulates growth of prostate cancer cells in culture. Nutr Cancer 2011; 63: 1361–1366. [CrossRef]
  32. Sutcliffe S, Giovannucci E, Isaacs WB, Willett WC, Platz EA. Acne and risk of prostate cancer. Int J Cancer 2007; 121: 2688–2692. [CrossRef]

Restriction of milk consumption or generation of less insulinotropic milk will have an enormous impact on the prevention of epidemic western diseases like obesity, diabetes mellitus, cancer, neurodegenerative diseases and acne

Nestle Nutr Workshop Ser Pediatr Program. 2011;67:131-45. Epub 2011 Feb 16.

Evidence for acne-promoting effects of milk and other insulinotropic dairy products.

Source

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.

Abstract

Acne vulgaris, the most common skin disease of western civilization, has evolved to an epidemic affecting more than 85% of adolescents. Acne can be regarded as an indicator disease of exaggerated insulinotropic western nutrition. Especially milk and whey protein-based products contribute to elevations of postprandial insulin and basal insulin-like growth factor-I (IGF-I) plasma levels. It is the evolutional principle of mammalian milk to promote growth and support anabolic conditions for the neonate during the nursing period. Whey proteins are most potent inducers of glucose-dependent insulinotropic polypeptide secreted by enteroendocrine K cells which in concert with hydrolyzed whey protein-derived essential amino acids stimulate insulin secretion of pancreatic β-cells. Increased insulin/IGF-I signaling activates the phosphoinositide-3 kinase/Akt pathway, thereby reducing the nuclear content of the transcription factor FoxO1, the key nutrigenomic regulator of acne target genes. Nuclear FoxO1 deficiency has been linked to all major factors of acne pathogenesis, i.e. androgen receptor transactivation, comedogenesis, increased sebaceous lipogenesis, and follicular inflammation. The elimination of the whey protein-based insulinotropic mechanisms of milk will be the most important future challenge for nutrition research. Both, restriction of milk consumption or generation of less insulinotropic milk will have an enormous impact on the prevention of epidemic western diseases like obesity, diabetes mellitus, cancer, neurodegenerative diseases and acne.

Copyright © 2011 S. Karger AG, Basel.

PMID:
 
21335995
 
[PubMed - indexed for MEDLINE]

Plaats een reactie ...

Reageer op "Melk en melkproducten en voeding met een hoge glycemische index - westers dieet - spelen grote rol in de vorming van acne en staan aan de basis van veel immuunziektes als diabetes 2 en ook kanker"


Gerelateerde artikelen
 

Gerelateerde artikelen

Koemelk vergroot significant >>