10 januari 2005: Bron: Pubmed: Gan To Kagaku Ryoho. 2001 Feb;28(2):217-20.

Vrouw van 51 jaar met uitgezaaide borstkanker ondergaat met succes een combinatiebehandeling met CEF (cyclophosphamide, epirubicin, 5-fluorouracil) en 5'-DFUR (5'-deoxy-5-fluorouridine) + MPA (medroxyprogesterone acetate), haar uitzaaiingen verdwijnen na de operatie,  Nieuw bewijs van uitstekend effect van met name 5'-DFUR (5'-deoxy-5-fluorouridine) + MPA (medroxyprogesterone acetate) bij uitgezaaide borstkanker. Zie ook andere case studies onder patientenervaringen.

[Advanced breast cancer with multiple bone metastases successfully treated with combined chemoendocrine-therapy of CEF (cyclophosphamide, epirubicin, 5-fluorouracil) and 5'-DFUR (5'-deoxy-5-fluorouridine) + MPA (medroxyprogesterone acetate)--a case report] Fukuda Y, Hirao S, Koyama I, Takatori H, Terakura M, Mayumi K, Tsukazaki Y, Kinoshita H. Dept. of Surgery, Tsukazaki Hospital. We report the case of a 51-year-old female with stage IV advanced breast cancer accompanied by multiple bone metastases. A hard mass of about 3.0 cm in diameter was palpated just below the nipple. An excisional biopsy was performed and histological examination revealed infiltrated solid tubular adenocarcinoma. There were no estrogen or progesterone receptors in the tumor. Modified radical mastectomy was performed in October, 1998. Postoperative adjuvant therapy with 10 cycles of CEF therapy was undertaken for one year. Combined chemoendocrine therapy with 5'-DFUR and MPA was also conducted for 11 months. Bone scintigraphy showed that all bone metastatic lesions disappeared completely one year after the operation. Mild bone marrow suppression, alopecia and body weight gain were observed as side effects. It is suggested that this combination therapy may be useful for advanced breast cancer patients with multiple bone metastases. PMID: 11242649 [PubMed - indexed for MEDLINE]


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