5 oktober 2023: Zie ook dit artikel in gerelateerde artikelen: https://kanker-actueel.nl/groene-thee-en-in-het-bijzonder-egcg-in-relatie-tot-gezondheid-en-ziekte-waaronder-kanker-een-review-van-arts-bioloog-drs-engelbert-valstar-aan-de-hand-van-de-literatuur.html

5 oktober 2023: Bron: BMC Gastroenterology volume 23, Article number: 294 (2023)

Uit een meta-analyse van totaal 239 studies uitgevoerd door Yu Huang van het Department of Biomedical Sciences, City University of Hong Kong blijkt het dagelijks drinken van enkele koppen thee en dan vooral groene thee het risico op het ontwikkelen van vormen van darmkanker met 24 procent te verminderen. Maar zeggen ook de auteurs dit percentage is ook onzeker omdat het werkelijke effect op het risico kan variëren van een reductie van 51% tot een toename van 18%, maar regionale en bevolkingsverschillen kunnen deze verschillen hebben veroorzaakt.
Wel geeft groene thee een substantiële vermindering van het risico over alle studies gemeten.
Bij zwarte thee verschilden echter de studieresultaten zo sterk dat er geen eenduidige conclusie is te trekken, aldus de auteurs van een meta-analyse.

Ik ga hier niet verder in op details omdat het volledige studierapport gratis is te lezen of te downloaden en daar staat heel veel gedetailleerde informatie met grafieken en refentielijst. Dus kunt u zelf een en ander opzoeken.

Achtereenvolgens abstract van de meta-analyse en abstract van een gerandomiseerde studie met groene thee extract en kwaadaardige darmpoliepen (adenomen):

Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study

BMC Gastroenterology volume 23, Article number: 294 (2023) Cite this article

 

Abstract

Purpose

A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk.

Methods

Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by two reviewers independently.We screened the literature based on inclusion and exclusion criteria. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results

We included fourteen articles in this meta-analysis. We analyzed the data using a random effect model to explore the association between tea consumption and CRC because of apparent heterogeneity (P < 0.001, I2 = 99.5%). The combined results of all tests showed that there is no statistically significant association between tea consumption and CRC risk (OR = 0.756, 95%CI = 0.470–1.215, P = 0.247). Subsequently, subgroup analysis and sensitivity analysis were performed. Excluding any single study, the overall results ranged from 0.73 (95%CI = 0.44–1.20) to 0.86 (95%CI = 0.53–1.40). It was determined that there was no significant publication bias between tea consumption and CRC risk (P = 0.064) by Egger's tests.

Conclusions

The results indicated that tea consumption may not be significantly associated with the development of CRC.

Implications of key findings

Tea reduces colon cancer risk by 24%, but the estimate is uncertain. The actual effect on risk can range from a reduction of 51% to an increase of 18%, but regional and population differences may cause differences.

epigallocatechingallate (EGCG) was well tolerated, but there was no statistically significant difference in the adenoma rate between the GTE group and the placebo groups in the whole study population

Abstract

Introduction: Preclinical, epidemiological, and small clinical studies suggest that green tea extract (GTE) and its major active component epigallocatechingallate (EGCG) exhibit antineoplastic effects in the colorectum.

Methods: A randomized, double-blind trial of GTE standardized to 150 mg of EGCG b.i.d. vs placebo over 3 years was conducted to prevent colorectal adenomas (n = 1,001 with colon adenomas enrolled, 40 German centers). Randomization (1:1, n = 879) was performed after a 4-week run-in with GTE for safety assessment. The primary end point was the presence of adenoma/colorectal cancer at the follow-up colonoscopy 3 years after randomization.

Results: The safety profile of GTE was favorable with no major differences in adverse events between the 2 well-balanced groups. Adenoma rate in the modified intention-to-treat set (all randomized participants [intention-to-treat population] and a follow-up colonoscopy 26-44 months after randomization; n = 632) was 55.7% in the placebo and 51.1% in the GTE groups. This 4.6% difference was not statistically significant (adjusted relative risk 0.905; P = 0.1613). The respective figures for the per-protocol population were 54.3% (151/278) in the placebo group and 48.3% (129/267) in the GTE group, indicating a slightly lower adenoma rate in the GTE group, which was not significant (adjusted relative risk 0.883; P = 0.1169).

Discussion: GTE was well tolerated, but there was no statistically significant difference in the adenoma rate between the GTE and the placebo groups in the whole study population.

Trial registration: ClinicalTrials.gov NCT01360320.

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Referenties meta-analyse studie

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Acknowledgements

We would like to thank the researchers and study participants for their contributions.

Funding

This work was supported by Hebei Provincial Natural Science Foundation precision medicine joint project (H2020206485) and Hebei Provincial Department of science and technology key project (206Z7705G).

Author information

Author notes

  1. Yu Huang and Qiang Chen contributed equally to this work and share first authorship.

Authors and Affiliations

  1. Department of Gastrointestinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, P.R. China

    Yu Huang, Qiang Chen, Yating Liu, Xu Yin, Yaoguang Hao, Yang Yang, Suyang Yu, Hongyan Li & Guiying Wang

  2. Department of Clinical Medical College, Tianjin Medical University, Tianjin, P.R. China

    Ruoxi Tian

  3. Department of Thoracic Surgery Gastrointestinal Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang, P.R. China

    Jian Yang

  4. Department of Vascular Surgery Gastrointestinal Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang, P.R. China

    Zongxuan Li

Contributions

Yu Huang, Hongyan Li, Suyang Yu and Guiying Wang contributed to conception and design of the study. Qiang Chen, Yating Liu, Ruoxi Tian, Xu Yin, Yaoguang Hao, Yang Yang acquired and analyzed the data. Yating Liu and Yu Huang drafted and revised a significant portion of the manuscript or figures. Zongxuan Li, Xu Yin and Jian Yang conducted the statistical analysis. Yu Huang, Qiang Chen, Yating Liu and Xu Yin wrote the paper. All authors read and approved the present version of manuscript to be published.

Corresponding authors

Correspondence to Suyang Yu, Hongyan Li or Guiying Wang.

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