Zie ook in gerelateerde artikelen

16 januari 2024: bronnen diverse websites en publicaties

Afgelopen weken wees Nicole mij op Innovitalife, een bedrijf in Litouwen, waar zij twee verschillende vormen van immuuntherapie krijgt voor haar vorm van uitgezaaide inoperabele vorm van lobulaire borstkanker.
Eerst krijgt zij 4 keer een injectie met zogeheten gemoduleerde UBC-nk cellen gevolgd door dendritische celtherapie die 4 weken op kweek hebben gestaan. Zij stuurde mij een korte onderzoeksamenvatting van gemoduleerde UBC-nk cellen bij borstkanker mee in haar e-mail.

Wat is gemoduleerde UBC-nk celtherapie precies?

Natural killer cellen ofwel NK-cellen zijn grote lymfocyten (wittebloedcellen) die behoren tot het aangeboren immuunsysteem en die een rol spelen bij celdoding en uitscheiding van cytokinen die worden gebruikt tegen ziekteverwekkers. Vrouwen kunnen hun navelstrengbloed in laten vriezen om eventueel later te gebruiken mochten zij kanker krijgen. Of zijzelf of een familielid of een verwante donor. Voor deze laatste groep zal het opgeslagen navelstrengbloed in de meeste gevallen gebruikt worden.

En inmiddels is het ook mogelijk om gemoduleerde UBC-nk celtherapie te krijgen. In regulier verband alleen nog in studieverband, maar in commerciële klinieken zoals Innovitalife dus nu ook. Wel tegen een fors prijskaartje

Stamceltransplantatie met navelstrengbloed en gemoduleerd niet verwant navelstrengbloed wordt sinds 1988 al gedaan bij vormen van leukemie. Citaat uit deze studie opzet:

Hematopoëtische voorlopercellen (HPC- primitieve cellen in het bloed, beenmerg en navelstreng die het beenmerg kunnen herstellen) transplantatie kan een curatieve therapie zijn voor de behandeling van hematologische maligniteiten (een ziekte van het beenmerg en de lymfeklieren). De bron van cellen die voor de transplantatie worden gebruikt, is afkomstig van verwante (broer of zus) en in gevallen waarin er geen match is tussen broers en zussen, van niet-verwante donoren via het National Marrow Donor Program. De beschikbaarheid van een geschikte donor kan een belangrijk obstakel zijn voor patiënten die een transplantatie nodig hebben maar geen passende donor hebben. Navelstrengbloed dat kort na de geboorte uit een navelstreng is geoogst, heeft een rijke voorraad cellen die nodig zijn voor transplantatie. Dit opgeslagen navelstrengbloed wordt nu gebruikt om volwassenen te transplanteren zonder een gematchte donor

In 2012 schreef de Belgische oncologe Eva Lion dit artikel:

NK Cells: Key to Success of DC-Based Cancer Vaccines?

Waarin zij beschrijft hoe NK-celtherapie werkt. Inmiddels zijn we 12 jaar verder en wordt nu dus ook gewerkt met gemoduleerde NK-cellen.

Gemoduleerde UBC-nk therapie wordt naast onderzoek bij borstkanker en AML - Acute Myeloide Leukemie inmiddels ook bij gevorderde eierstokkanker onderzocht in Nederland, zie dit studieprotocol in het Engels.
Hier een samenvatting van het onderzoek in het Nederlands waarbij dus ook gebruik gemaakt wordt van chimere antigeenreceptoren (CAR-T cellen).

Beide studies staan onder leiding van prof. dr. Dolstra. Hij wordt gezien als een van de specialisten op het gebied van gemoduleerde UBC-nk celtherapie.

In het NtvO van december 2020 is een interessant artikel te lezen met als titel:

AMERIKAANSE ONDERZOEKERS MAKEN NATURAL KILLER CELLEN NOG EFFECTIEVER TEGEN KANKER

december 2020 MEDISCH ONDERZOEK Willem van Altena

Het menselijk afweersysteem is in principe prima in staat om kankercellen te doden. Maar kankercellen blijken op allerlei manieren in staat te zijn om het immuunsysteem om de tuin te leiden en niet door afweercellen herkend te worden. Onderzoekers aan Penn State University in de Verenigde Staten onder leiding van professor Yong Wang denken een manier gevonden om dat tegen te gaan. Door speciaal ontworpen ‘natural killer cellen’ (NK-cellen) kunnen tumorcellen alsnog herkend en opgeruimd worden. Het Duitse vaktijdschrift Angewandte Chemie presenteerde in haar internationale editie het onderzoek van Wang en zijn team.>>>>>>>lees verder

Dit bovenstaande artikel uit het NtvO is gebaseerd op deze studie:

In Situ Synthesis of an Aptamer-Based Polyvalent Antibody Mimic on the Cell Surface for Enhanced Interactions between Immune and Cancer Cells

Dr. Peng Shi, Xuelin Wang, Brandon Davis, James Coyne, Prof. Cheng Dong, Joshua Reynolds, Prof. Yong Wang

First published: 19 April 2020

https://doi.org/10.1002/anie.202004206

Citations: 50

Graphical Abstract

Killer instinct: A supramolecular polyvalent antibody mimic (PAM) has been synthesized in situ on the surface of natural killer cells by nucleic acid assembly and hybridization under physiological conditions without genetic manipulation. The PAM-engineered natural killer cells (green) possess a superb ability to bind to and kill cancer cells (red) and thus constitute a promising technology platform for cancer immunotherapy.

Abstract

An ability to promote therapeutic immune cells to recognize cancer cells is important for the success of cell-based cancer immunotherapy. We present a synthetic method for functionalizing the surface of natural killer (NK) cells with a supramolecular aptamer-based polyvalent antibody mimic (PAM). The PAM is synthesized on the cell surface through nucleic acid assembly and hybridization. The data show that PAM has superiority over its monovalent counterpart in powering NKs to bind to cancer cells, and that PAM-engineered NK cells exhibit the capability of killing cancer cells more effectively. Notably, aptamers can, in principle, be discovered against any cell receptors; moreover, the aptamers can be replaced by any other ligands when developing a PAM. Thus, this work has successfully demonstrated a technology platform for promoting interactions between immune and cancer cells.

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