11 september 2013: N.a.v. de uitspraken van prof. dr. Ron Matthijssen  in de Volkskrant van 11 september 2013 heb ik dit artikel over St. Jans Kruid maar even naar voren gehaald. Wat voor zichzelf spreekt lijkt mij.

30 april 2011: Bron J Altern Complement Med.  2009 Aug;15(8):827-36

St. Jans kruid heeft een even effectief effect op depressies dan antidepressiva. Dit was al langer bekend en in de apotheek is ook St. Jans kruid op recept verkrijgbaar. Onderstaande meta analyse van beschikbare studies bevestigt de conclusie dat St Jans Kruid als medicijn kan worden voorgeschreven bij depressies.

Kava and St. John's Wort: current evidence for use in mood and anxiety disorders

Jerome Sarris, M.H.Sc.,1 and
David J. Kavanagh, Ph.D.2
1School of Medicine, The University of Queensland, Royal Brisbane and Women’s Hospital, Queensland, Brisbane, Australia.
2Institute of Health & Biomedical Innovation, Queensland University of Technology, Queensland, Brisbane, Australia.
Address correspondence to:

Jerome Sarris, M.H.Sc.

Mental Health Centre

School of Medicine

The University of Queensland
Royal Brisbane and Women’s Hospital

Royal Brisbane Hospital

Floor K

Herston Road, Herston 4006

Brisbane, Queensland

Australia
E-mail:

Abstract

Background: Mood and anxiety disorders pose significant health burdens on the community. Kava and St. John's wort (SJW) are the most commonly used herbal medicines in the treatment of anxiety and depressive disorders, respectively.

Objectives: The objective of this study was to conduct a comprehensive review of kava and SJW, to review any evidence of efficacy, mode of action, pharmacokinetics, safety and use in major depressive disorder, bipolar disorder, seasonal affective disorder (SAD), generalized anxiety disorder, social phobia (SP), panic disorder (PD), obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD).

Methods: A systematic review was conducted using the electronic databases MEDLINE, CINAHL, and The Cochrane Library during late 2008. The search criteria involved mood and anxiety disorder search terms in combination with kava, Piper methysticum, kavalactones, St. John's wort, Hypericum perforatum, hypericin, and hyperforin. Additional search criteria for safety, pharmacodynamics, and pharmacokinetics were employed. A subsequent forward search was conducted of the papers using Web of Science cited reference search.

Results: Current evidence supports the use of SJW in treating mild–moderate depression, and for kava in treatment of generalized anxiety. In respect to the other disorders, only weak preliminary evidence exists for use of SJW in SAD. Currently there is no published human trial on use of kava in affective disorders, or in OCD, PTSD, PD, or SP. These disorders constitute potential applications that warrant exploration.

Conclusions: Current evidence for herbal medicines in the treatment of depression and anxiety only supports the use of Hypericum perforatum for depression, and Piper methysticum for generalized anxiety.

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