1 juni 2010: Bron:Cancer Epidemiol Biomarkers Prev. 2010 May 26.

Regelmatig gebruik van een zonnebank geeft een sterk vergroot risico op het krijgen van een onderhuidse vorm van huidkanker, een melanoom. Dit blijkt uit een groot bevolkingsonderzoek in Minnesota. Sommige zonnebanken gaven minder risico maar geen enkele zonnebank bleek veilig. Bij de groep mensen (die melanoma hadden ontwikkeld bleken veel meer mensen regelmatig gebruik te hebben gemaakt van een zonnebank dan bij de mensen die geen melanoma hadden ontwikkeld. Hier het abstract en klik hier voor artikel uit Medscape.

Indoor Tanning and Risk of Melanoma: A Case-Control Study in a Highly Exposed Population.

Lazovich D, Vogel RI, Berwick M, Weinstock MA, Anderson KE, Warshaw EM.

Authors' Affiliations: 1Division of Epidemiology and Community Health, 2Masonic Cancer Center, and 3Department of Dermatology, University of Minnesota, Minneapolis, Minnesota; 4Department of Internal Medicine and University of New Mexico Cancer Center and 5Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, New Mexico; 6Dermatoepidemiology Unit, VA Medical Center, 7Department of Dermatology, Rhode Island Hospital, and Departments of 8Dermatology and Community Health, Brown University, Providence, Rhode Island; and 9Department of Dermatology, VA Medical Center, Minneapolis, Minnesota.

Abstract

BACKGROUND: Indoor tanning has been only weakly associated with melanoma risk; most reports were unable to adjust for sun exposure, confirm a dose-response, or examine specific tanning devices. A population-based case-control study was conducted to address these limitations.

METHODS: Cases of invasive cutaneous melanoma, diagnosed in Minnesota between 2004 and 2007 at ages 25 to 59, were ascertained from a statewide cancer registry; age-matched and gender-matched controls were randomly selected from state driver's license lists. Self-administered questionnaires and telephone interviews included information on ever use of indoor tanning, types of device used, initiation age, period of use, dose, duration, and indoor tanning-related burns. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for known melanoma risk factors.

RESULTS: Among 1,167 cases and 1,101 controls, 62.9% of cases and 51.1% of controls had tanned indoors (adjusted OR 1.74; 95% CI, 1.42-2.14). Melanoma risk was pronounced among users of UVB-enhanced (adjusted OR, 2.86; 95% CI, 2.03-4.03) and primarily UVA-emitting devices (adjusted OR, 4.44; 95% CI, 2.45-8.02). Risk increased with use: years (P < 0.006), hours (P < 0.0001), or sessions (P = 0.0002). ORs were elevated within each initiation age category; among indoor tanners, years used was more relevant for melanoma development.

CONCLUSIONS: In a highly exposed population, frequent indoor tanning increased melanoma risk, regardless of age when indoor tanning began. Elevated risks were observed across devices. Impact: This study overcomes some of the limitations of earlier reports and provides strong support for the recent declaration by the IARC that tanning devices are carcinogenic in humans. Cancer Epidemiol Biomarkers Prev; 19(6); 1557-68. (c)2010 AACR.

PMID: 20507845 [PubMed - as supplied by publisher]

melanoma, tanning, indoor, minnesota, devices, adjusted, zonnebank, mexico, dermatology, controls