12 april 2011: Bron: CMAJ. 2010 Dec 14;182(18):1953-8

Het toedienen van EPA via bloedtransfusies bij de oudere kankerpatient om bloedarmoede te bestrijden vergroot de kans op eerder overlijden. Dit blijkt uit een Nederlandse studie uitgevoerd aan het LUMC. Hier het abstract van de studie en is in lijn met de grote meta analyse die in 2009 in The Lancet  werd gepubliceerd en uitgevoerd bij kankerpatienten van alle leeftijden.

Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study

CMAJ. 2010 Dec 14;182(18):1953-8.

Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study.

den Elzen WP, Willems JM, Westendorp RG, de Craen AJ, Blauw GJ, Ferrucci L, Assendelft WJ, Gussekloo J.

Department of Public Health and Primary Care, Leiden University Medical Center, the Netherlands. w.p.j.den_elzen@lumc.nl

Comment in:

 

Abstract

BACKGROUND: The production of erythropoietin is triggered by impaired oxygen delivery to the kidney, either because of anemia or hypoxemia. High erythropoietin levels have been shown to predict the risk of death among patients with chronic heart failure. We investigated the prognostic value of elevated erythropoietin levels on mortality among very elderly people in the general population.

METHODS: The Leiden 85-plus Study is a population-based prospective follow-up study involving 599 people aged 85 years in Leiden, the Netherlands, enrolled between September 1997 and September 1999. Erythropoietin levels were determined at age 86. For this analysis, we included 428 participants with a creatinine clearance of at least 30 mL/min. Mortality data, recorded until Feb. 1, 2008, were obtained from the municipal registry.

RESULTS: During follow-up, 324 (75.7%) participants died. Compared with participants whose erythropoietin levels were in the lowest tertile (reference group), those whose levels were in the middle tertile had a 25% increased risk of death (hazard ratio 1.25, 95% confidence interval 0.95-1.64), and those whose levels were in the highest tertile had a 73% increased risk (HR 1.73, 95% CI 1.32-2.26) (p value for trend < 0.01). The association between erythropoietin levels and mortality remained largely unchanged after we adjusted for sex, creatinine clearance, hemoglobin level, comorbidity, smoking status and C-reactive protein level, and was similar for deaths from cardiovascular and noncardiovascular causes.

INTERPRETATION: Among people aged 85 years and older, elevated erythropoietin levels were associated with an increased risk of death, independent of hemoglobin levels.

PMID: 21149533 [PubMed - indexed for MEDLINE]PMCID: PMC3001501


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