PDT - Photo Dynamische Therapie net zo effectief als bisfosfonaten bij botuitzaaiingen vanuit borstkanker

1 december 2011: Bron: Breast Cancer Research and Treatment Volume 124, Number 1, 111-119, DOI: 10.1007/s10549-009-0712-7

Wanneer dieren met botuitzaaiingen voor die bottumoren worden behandeld met PDT - Photo Dynamische Therapie dan werkt dit net zo goed op het verdwijnen van de tumor en op de botdichtheid en sterkte van het bot dan een bisfosfonaat. Dit toont een dierstudie met ratten aan. Het abstract is kort en geeft weinig informatie, maar wie meer wilt weten kan het volledige studierapport hier tegen betaling inzien De referentielijst die ik erbij staat geeft ook nog wat meer informatie

Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue

Breast Cancer Research and Treatment

Volume 124, Number 1, 111-119, DOI: 10.1007/s10549-009-0712-7

Abstract

Breast cancer patients commonly develop metastases in the spine, which compromises its mechanical stability and can lead to skeletal related events. The current clinical standard of treatment includes the administration of systemic bisphosphonates (BP) to reduce metastatically induced bone destruction. However, response to BPs can vary both within and between patients, which motivates the need for additional treatment options for spinal metastasis. Photodynamic therapy (PDT) has been shown to be effective at treating metastatic lesions secondary to breast cancer in an athymic rat model, and is proposed as a treatment for spinal metastasis. The objective of this study was to determine the effect of PDT, alone or in combination with previously administered systemic BPs, on the structural and mechanical integrity of both healthy and metastatically involved vertebrae. Human breast carcinoma cells (MT-1) were inoculated into athymic rats (day 0). At 14 days, a single PDT treatment was administered, with and without previous BP treatment at day 7. In addition to causing tumor necrosis in metastatically involved vertebrae, PDT significantly reduced bone loss, resulting in strengthening of the vertebrae compared to untreated controls. Combined treatment with BP + PDT further enhanced bone architecture and strength in both metastatically involved and healthy bone. Overall, the ability of PDT to both ablate malignant tissue and improve the structural integrity of vertebral bone motivates its consideration as a local minimally invasive treatment for spinal metastasis secondary to breast cancer.

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