25 maart 2007: Bron: 1: Clin Pharmacol Ther. 2007 Feb 21;

Prenataal gebruik van extra multi vitamines geeft significant minder risico op leukemie en hersentumoren bij kinderen in hun kindertijd. Dit blijkt uit een grote meta analyse van ruim 60 gerandomiseerde studies.

Prenatal Multivitamin Supplementation and Rates of Pediatric Cancers: A Meta-Analysis. Goh YI, Bollano E, Einarson TR, Koren G.
[1] 1Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada [2] 2The Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Prenatal supplementation of folic acid has been shown to decrease the risk of several congenital malformations. Several studies have recently suggested a potential protective effect of folic acid on certain pediatric cancers. The protective role of prenatal multivitamins has not been elucidated. We conducted a systematic review and meta-analysis to assess the potential protective effect of prenatal multivitamins on several pediatric cancers. Medline, PubMed, EMBASE, Toxline, Healthstar, and Cochrane databases were searched for studies published in all languages from 1960 to July 2005 on multivitamin supplementation and pediatric cancers. References from all articles collected were reviewed for additional articles. Two blinded independent reviewers assessed the articles for inclusion and exclusion. Rates of cancers in women supplemented with multivitamins were compared with unsupplemented women using a random effects model. Sixty-one articles were identified in the initial search, of which, seven articles met the inclusion criteria.

There was an apparent protective effect for leukemia (odds ratio (OR)=0.61, 95% confidence interval (CI)=0.50-0.74), pediatric brain tumors (OR=0.73, 95% CI=0.60-0.88) and neuroblastoma (OR=0.53, 95% CI=0.42-0.68). In conclusion, maternal ingestion of prenatal multivitamins is associated with a decreased risk for pediatric brain tumors, neuroblastoma, and leukemia. Presently, it is not known which constituent(s) among the multivitamins confer this protective effect.Clinical Pharmacology & Therapeutics advance online publication, 21 February 2007. doi:10.1038/sj.clpt.6100100.

PMID: 17314929 [PubMed - as supplied by publisher]

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