Wie advies wilt over hoe het microbioom te verbeteren zou contact op kunnen nemen met deze website: Www.microbiome-Center.nl Voor zowel artsen als individuele burgers staat een groep van artsen en wetenschappers klaar om u een persoonlijk advies te geven.
12 juli 2022:
Een placebo gecontroleerde postpectieve studie (zie dit studieprotocol ) bewijst dat de werkzaamheid op lange termijn van een poeptransplantatie (fecale microbiota-transplantatie (FMT)) bij patiënten met het Prikkelbare Darm Syndroom (PDS) deze patiënten blijft helpen in het onderdrukken van de symptomen. Ook hun kwaliteit van leven blijkt op 3-jaars meting stukken beter in vergelijking met de patiënten die een placebo kregen. Patiënten die een poeptransplantatie (FMT) ondergingen hadden minder IBS-symptomen en hogere Kwaliteit van Leven scores op zowel 2 als 3 jaar.
De onderzoekers identificeerden ook signalen van 10 bacteriemarkers die correleerden met IBS-symptomen bij patiënten die FMT ondergingen.
In eerdere studies is al bewezen dat een poeptransplantatie patiënten met de darminfectie Clostridium difficile snel kan genezen, zie daarvoor dit artikel waarin video opgenomen hoe een poeptransplantatie in zijn werk gaat: https://kanker-actueel.nl/ontlasting-vaccin-via-neussonde-geneest-darminfectie-clostridium-difficile-razendsnel-en-effectief-90-procent-van-de-patienten-herstelt-binnen-24-uur.html
Het studieverslag van de eerst genoemde studie is een vervolg op dit studierapport dat vorig jaar online werd gepubliceerd. Klik op de titel voor het abstract:
Long-term effects of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome
- PMID: 34145677
- DOI: 10.1111/nmo.14200
Abstract
Background: We recently found fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) patients to be an effective and safe treatment after 3 months. The present follow-up study investigated the efficacy and safety of FMT at 1 year after treatment.
Methods: This study included 77 of the 91 IBS patients who had responded to FMT in our previous study. Patients provided a fecal sample and completed five questionnaires to assess their symptoms and quality of life at 1 year after FMT. The dysbiosis index (DI) and fecal bacterial profile were analyzed using a 16S rRNA gene-based DNA probe hybridization. The levels of fecal short-chain fatty acids (SCFAs) were determined by gas chromatography.
Results: There was a persistent response to FMT at 1 year after treatment in 32 (86.5%) and 35 (87.5%) patients who received 30-g and 60-g FMT, respectively. In the 30-g FMT group, 12 (32.4%) and 8 (21.6%) patients showed complete remission at 1 year and 3 months, respectively; the corresponding numbers in the 60-g FMT group were 18 (45%) and 11 (27.5%), respectively. Abdominal symptoms and the quality of life were improved at 1 year compared with after 3 months. These findings were accompanied by comprehensive changes in the fecal bacterial profile and SCFAs.
Conclusions: Most of the IBS patients maintained a response at 1 year after FMT. Moreover, the improvements in symptoms and quality of life increased over time. Changes in DI, fecal bacterial profile and SCFAs were more comprehensive at 1 year than after 3 months. www.clinicaltrials.gov (NCT03822299).
Keywords: fatigue; microbiome; short-chain fatty acids; superdonor; therapy.
© 2021 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.
Ook uit deze twee studies blijkt de effectiviteit:
- Hugerth LW, Andreasson A, Talley NJ, et al. No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population. Gut. 2020;69(6):1076-1084. https://gut.bmj.com/content/69/6/1076.citation-tools
- Zhao HJ, Zhang XJ, Zhang NN, et al. Fecal Microbiota Transplantation for Patients With Irritable Bowel Syndrome: A Meta-Analysis of Randomized Controlled Trials. Front Nutr. 2022;9:890357. https://www.frontiersin.org/articles/10.3389/fnut.2022.890357/full
Similar articles
-
Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome.Neurogastroenterol Motil. 2021 Feb;33(2):e13983. doi: 10.1111/nmo.13983. Epub 2020 Sep 17.PMID: 32945066 Free PMC article. Clinical Trial.
-
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels.Scand J Gastroenterol. 2019 Jun;54(6):690-699. doi: 10.1080/00365521.2019.1624815. Epub 2019 Jun 13.PMID: 31190584 Clinical Trial.
-
Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome.World J Gastroenterol. 2021 May 14;27(18):2219-2237. doi: 10.3748/wjg.v27.i18.2219.PMID: 34025075 Free PMC article. Clinical Trial.
-
Fecal microbiota transplantation for managing irritable bowel syndrome.Expert Rev Gastroenterol Hepatol. 2018 May;12(5):439-445. doi: 10.1080/17474124.2018.1447380. Epub 2018 Mar 8.PMID: 29493330 Review.
-
Can fecal microbiota transplantation cure irritable bowel syndrome?World J Gastroenterol. 2017 Jun 14;23(22):4112-4120. doi: 10.3748/wjg.v23.i22.4112.PMID: 28652664 Free PMC article. Review.
References
- El-Salhy M, Mazzawi T. Fecal microbiota transplantation for managing irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 2018;12(5):439-445.
- El-Salhy M. Irritable bowel syndrome: diagnosis and pathogenesis. World J Gastroenterol. 2012;18:5151-5163.
- Talley NJ, Gabriel SE, Harmsen WS, Zinsmeister AR, Evans RW. Medical costs in community subjects with irritable bowel syndrome. Gastroenterology. 1995;109:1736-1741.
- Jones R, Lydeard S. Irritable bowel syndrome in the general population. BMJ. 1992;304:87-90.
- Hungin AP, Whorwell PJ, Tack J, Mearin F. The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects. Aliment Pharmacol Ther. 2003;17:643-650.
- Hugerth LW, Andreasson A, Talley NJ, et al. No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population. Gut. 2020;69(6):1076-1084.
- El-Salhy M, Hatlebakk JG, Gilja OH, Brathen Kristoffersen A, Hausken T. Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study. Gut. 2020;69(5):856-867.
- Francis CY, Morris J, Whorwell PJ. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment pharmacol Ther. 1997;11(2):395-402.
- Hendriks C, Drent M, Elfferich M, De Vries J. The fatigue assessment scale: quality and availability in sarcoidosis and other diseases. Curr Opin Pulm Med. 2018;24(5):495-503.
- Drossman DA, Patrick DL, Whitehead WE, et al. Further validation of the IBS-QOL: a disease-specific quality-of-life questionnaire. American J Gastroenterol. 2000;95:999-1007.
- Wong RK, Drossman DA. Quality of life measures in irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 2010;4(3):277-284.
- Arslan G, Lind R, Olafsson S, Florvaag E, Berstad A. Quality of life in patients with subjective food hypersensitivity: applicability of the 10-item short form of the Nepean dyspepsia Index. Dig Dis Sci. 2004;49:680-687.
- Casén C, Vebø HC, Sekelja M, et al. Deviations in human gut microbiota: a novel diagnostic test for determining dysbiosis in patients with IBS or IBD. Aliment Pharmacol Ther. 2015;42(1):71-83.
- Enck P, Mazurak N. Dysbiosis in functional bowel disorders. Ann Nutr Metab. 2018;72(4):296-306.
- Zijlstra JB, Beukema J, Wolthers BG, Byrne BM, Groen A, Dankert J. Pretreatment methods prior to gaschromatographic analysis of volatile fatty acids from faecal samples. Clin Chim Acta. 1977;78(2):243-250.
- Hoverstad T, Fausa O, Bjorneklett A, Bohmer T. Short-chain fatty acids in the normal human feces. Scand J Gastroenterol. 1984;19(3):375-381.
- Holvoet T, Joossens M, Vázquez-Castellanos JF, et al. Fecal microbiota transplantation reduces symptoms in some patients with irritable bowel syndrome with predominant abdominal bloating: short- and long-term results from a placebo-controlled randomized trial. Gastroenterology. 2021;160(1):145-157.e8. https://doi.org/10.1053/j.gastro.2020.07.013
- Mishra AK, Gimenez G, Lagier JC, Robert C, Raoult D, Fournier PE. Genome sequence and description of Alistipes senegalensis sp. nov. Stand Genomic Sci. 2012;6(3):1-16.
- Sun Q, Jia Q, Song L, Duan L. Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome: a systematic review and meta-analysis. Medicine. 2019;98(7):e14513.
- El-Salhy M, Valeur J, Hausken T, Gunnar HJ. Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2021;33(2):13983.
- Tana C, Umesaki Y, Imaoka A, Handa T, Kanazawa M, Fukudo S. Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterol Motil. 2010;22(5):512-519, e114-515.
- Winston J, Shenoy M, Medley D, Naniwadekar A, Pasricha PJ. The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats. Gastroenterology. 2007;132(2):615-627.
- Valeur J, Roseth AG, Knudsen T, et al. Fecal fermentation in irritable bowel syndrome: influence of dietary restriction of fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Digestion. 2016;94:50-56.
- Halder SL, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ. Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study. Gastroenterology. 2007;133(3):799-807.
Gerelateerde artikelen
- Poeptransplantatie: Ontlasting behandeling via neussonde geneest darminfectie - Clostridium difficile razendsnel en effectief. 90 procent van de patienten herstelt binnen 24 uur.
- Een poeptransplantatie als behandeling van een Clostridium difficile darminfectie is bijzonder succesvol met beperkte bijwerkingen. 90 procent geneest na 1 maand en 1 transplantatie
- Ziekte van Crohn artikelen
Plaats een reactie ...
1 Reactie op "Poeptransplantatie - fecale microbiota-transplantatie van gezonde donor blijft jarenlang effectief bij patienten met Prikkelbare Darm Syndroom. Kwaliteit van leven was veel beter in vergelijking met een placebo"