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Lees ook artikelen over probiotica bij operatie van darmkanker en andere vormen van kanker in overzicht probiotica en synbiotica.

22 juli 2019: Bron: Journal of Cancer

Wanneer maagkankerpatienten die een gedeeltelijke operatie van hun maag moeten ondergaan wegens kanker na de operatie een mix van probiotica gebruiken (Bifidobacterium infantis, Lactobacillus acidophilus, Enterococcus faecalis and Bacillus cereus) gedurende een week dan ervaren zij minder ernstige lichamelijke klachten en herstelt de darmflora sneller en komt de voedingsverwerking sneller op gang. Dit blijkt uit een placebo gecontroleerde gerandomiseerde studie bij totaal 100 patienten met maagkanker. Geen van de patienten heeft naast de operatie bestraling of chemo gekregen in deze studie om de resultaten zuiver te houden, zo schrijven de onderzoekers.

Hier een grafiek van de deelnemers bij de start van de studie:

Table 1

Baseline patient demographics and characteristics. AC, cancer patients after gastrectomy and treatment without probiotic combination; ACP, cancer patients after gastrectomy and treatment with probiotic combination.

VariableAC Group (N=50)ACP Group (N=50)P value
Percentage of total enrollment, No. (%) 50 (50.00) 50 (50.00) /
Male: female, n:n (%:%) 41:9 (82.00:18:00) 43:7 (86.00:14.00) 0.585
Age, y 64.00 (56.75-69.25) 60.00 (51.75-67.25) 0.122
Tumor category, No. (%)
T0 0 (0.00) 1 (2.00) 0.510
T1 6 (12.00) 3 (6.00)
T2 5 (10.00) 3 (6.00)
T3 9 (18.00) 7 (14.00)
T4 30 (60.00) 36 (72.00)
Node category, No. (%)
N0 16 (32.00) 16 (32.00) 0.772
N1 23 (46.00) 22 (44.00)
N2 6 (12.00) 9 (18.00)
N3 5 (10.00) 3 (6.00)
M category, No. (%)
M0 50 (100.00) 50 (100.00) /
TNM category, No. (%)
TNM1 9 (18.00) 6 (12.00) 0.347
TNM2 13 (26.00) 9(18.00)
TNM3 28 (54.00) 35 (70.00)

In the present study, our work showed that the probiotic combination of B. infantis, L. acidophilus, E. faecalis and B. cereus significantly enhanced the immunity of patients, reduced inflammation and was beneficial to restore the microbial diversity of patients who received gastrectomy. Therefore, the present randomised clinical trial illustrates the benefits of oral probiotics in the prevention of physiological and microbial disorders when provided to cancer patients after gastrectomy.

. 2019; 10(3): 568–576.
Published online 2019 Jan 1. doi: 10.7150/jca.29072
PMCID: PMC6360416
PMID: 30719153

A randomised trial of probiotics to reduce severity of physiological and microbial disorders induced by partial gastrectomy for patients with gastric cancer

Abstract

Gastrectomy has been widely used for the treatment of gastric cancer, and the severity of physiological and microbial disorders has greatly harmed the health of patients. In the present study, a probiotic combination containing Bifidobacterium infantis, Lactobacillus acidophilus, Enterococcus faecalis and Bacillus cereus was used to reduce the physiological disorders induced by gastrectomy via monitoring the blood index and microbial diversity using high-throughput sequencing. Our results indicated that the probiotic combination had significantly reduced the inflammation indexes (leukocyte) (p<0.05), while it markedly enhanced the immunity indexes (lymphocyte) and nutrition indexes (albumin and total protein) (p<0.05). In addition, gastric cancer had a strong influence on the microbial diversity of the stomach via enhancing the number of pathogens of Streptococcus, Peptostreptococcus and Prevotella, and reducing the percentage of the probiotic Bifidobacterium. Although partial gastrectomy markedly changed intestinal microbial diversity, the taking of the probiotic combination greatly reduced the ratio of Firmicutes/Bacteroidetes compared with patients taking no probiotics at the phylum level. At the genus level, the probiotic combination significantly enhanced the numbers of the probiotic bacteria Bacteroides, Faecalibacterium and Akkermansia and lowered the richness of Streptococcus. Therefore, we concluded that the taking of the probiotic combination significantly enhances the immune response of patients and reduces the severity of inflammation through modification of gut microbiota.

Consent for publication

Written informed consent was obtained from all participants.

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