16 november 2020: Aanvullend op onderstaande informatie klik op de titel van deze studie: Botanical Formula LCS101: A Multi-Targeted Approach to Cancer Care
14 april 2018: Lees ook dit artikel en klik op de volgende link:
22 juli 2011: Bron: The oncologist
Wanneer vrouwen met beginnende borstkanker die chemo krijgen (taxol, taxotere) daarbij oraal een capsule nemen met daarin een mix van Chinese kruiden, dan blijken die vrouwen veel minder last te hebben van de "normale" bijwerkingen als anemia - verminderde rode bloedlichaampjes, verminderde witte bloedlichaampjes (leukopenie en neutropenie) in vergelijking met de groep vrouwen die een placebo kregen. De verschillen waren statisch signicant beter voor de Chinese kruidenmix. anemia (p < .01) en leukopenia (p < .03) vergeleken graad 0–1 met graad 2–4, neutropenia (p < .04) vergeleken graad 0–2 met graad 3–4. Deze studie werd gepubliceerd in The Oncologist en als u hier klikt kunt u het volledige studie rapport inzien tegen betaling. Bij de natuurapotheek in Pijnacker kunt u uitstekende informatie krijgen over beschikbare Chinese kruiden in Nederland. Zij zijn gespecialiseerd in Chinese kruiden als medicijn.
Botanical Formula LCS101: A Multi-Targeted Approach to Cancer Care
Background and Purpose: LCS101 is a botanical formula extracted from 14 botanical components. While conventional oncology focuses on targeted medicine, research on LCS101 adopts a multi-targeted approach, examining its preclinical (in vitro, in vivo, and ex vivo) and clinical (randomized controlled trial, pragmatic) effects. This includes examining the formula’s impact on the immune system, selective anticancer effects, and improved chemotherapy-related symptoms and quality of life. Effects on the Immune System: In murine splenic cell cultures, LCS101 significantly increased T-cell proliferation and macrophage tumor necrosis factor-α production. Blood samples from healthy volunteers exposed to LCS101 showed a dose-dependent increase in natural killer cell activity; and a randomized controlled trial showed significantly lower rates of leucopenia/neutropenia and anemia in patients with breast cancer undergoing chemotherapy. Selective Anticancer Effects: In vitro LCS101 demonstrated selective growth inhibition (on XTT viability assay) in human breast and prostate cancer cell lines, without any harmful effects on normal human epithelial cells. The anticancer effects were attributed to reactive oxygen species activity. Cytotoxic effects of doxorubicin and 5-fluorouracil on breast cancer cell lines were significantly increased following exposure to LCS101, with a protective effect in normal cells. Symptom Relief and Quality of Life:
Effect of the botanical formula LCS101 on the anti-cancer effects of radiation therapy
Journal of Cancer Research and Clinical Oncology volume 145, pages609–613(2019
Background and purpose
The botanical formula LCS101 has been shown in clinical research to reduce chemotherapy-induced toxicities. In pre-clinical research, the formula demonstrated selective anti-cancer effects, in part as a result of radical oxygen species (ROS) activity of the botanical components. The present study examined the interaction between LCS101 and radiation therapy on cancer cell lines.
Incremental doses of LCS101 were added to breast adenocarcinoma (MCF7), prostate (DU145), transitional cell bladder carcinoma (T24), pancreatic epithelioid carcinoma (PANC-1), and osteosarcoma (U20S) cell lines 4 h after single-dose irradiation (range 0.5–4 Gy). Cell viability was tested using sulforhodamine B (SRB) assay after 1 week, with ROS activity examined using 1 mM of the ROS scavenger sodium pyruvate (ROS scavenger), testing cell viability with an SRB assay.
The addition of LCS101 to MCF7 (breast) and DU-145 (prostate) cancer cell lines resulted in a dose-dependent increase in the antiproliferative effects of radiation treatment. The addition of pyruvate inhibited radiation-induced cell death in all of the cell lines treated with LCS101.
The addition of the botanical formula LCS101 to irradiated cancer cells results in an apparent additive effect, most likely through a ROS-mediated mechanism. These findings support the use of LCS101 by patients undergoing radiation therapy, for both its clinical as well as anti-cancer effects.
The addition of LCS101 to anthracycline- and taxane-based chemotherapy is safe and well tolerated, and may significantly prevent some chemotherapy-induced hematological toxicities in early breast cancer patients.
A Prospective, Controlled Study of the Botanical Compound Mixture LCS101 for Chemotherapy-Induced Hematological Complications in Breast Cancer
- Neora Yaal-Hahoshena,
- Yair Maimonb,e,
- Nava Siegelmann-Danielid,
- Shahar Lev-Arib,
- Ilan G. Rona,
- Fani Sperberc,
- Noah Samuelsf,
- Jacob Shohamg and
- Ofer Merimskya
+ Author Affiliations
- aDepartment of Oncology, Tel Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;
- bUnit of Complementary Medicine and
- cBreast Imaging Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;
- dMaccabi Healthcare Services, Tel Aviv, Israel;
- eRefuot Integrative Medical Center, Tel Aviv, Israel;
- fCenter for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel;
- gFaculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel
- Correspondence: Yair Maimon, Ph.D., Refuot Integrative Medical Center, 18 Feinstein Street, Tel Aviv 69123, Israel. Telephone: 972-3-744–0888; Fax: 972-3-677-7768; e-mail: firstname.lastname@example.org
- Received April 28, 2011.
- Accepted May 19, 2011.
Disclosures: Neora Yaal-Hahoshen: None; Yair Maimon: Ownership interest: Lifebiotic Ltd.; Nava Siegelmann-Danieli: None; Shahar Lev-Ari: None; Ilan Ron: None; Fani Sperber: None; Noah Samuels: None; Jacob Shoham: None; Ofer Merimsky: None.
The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers.
Abstract Background. This prospective, controlled study evaluated the safety, tolerability, and efficacy of the mixture of botanical compounds known as LCS101 in preventing chemotherapy-induced hematological toxicity in breast cancer patients.
Methods. Female patients diagnosed with localized breast cancer were randomly allocated to receive treatment with either LCS101 or placebo capsules, in addition to conventional chemotherapy. The study intervention was initiated 2 weeks prior to the initiation of chemotherapy and continued until chemotherapy was completed, with participants receiving 2 g of LCS101 capsules thrice daily. Subjects were assessed for the development of hematological and nonhematological toxicities, as well as the tolerability and safety of the study intervention.
Results. Sixty-five breast cancer patients were recruited, with 34 allocated to LCS101 and 31 allocated to placebo treatment. Patients in the treatment group developed significantly less severe (grades 2–4) anemia (p < .01) and leukopenia (p < .03) when comparing grades 0–1 with grades 2–4, with significantly less neutropenia (p < .04) when comparing grades 0–2 with grades 3–4. This effect was more significant among patients undergoing a dose-dense regimen. No statistically significant effect was found with respect to nonhematological toxicities, and side effect rates were not significantly different between the groups, with no severe or life-threatening events observed in either group.
Conclusion. The addition of LCS101 to anthracycline- and taxane-based chemotherapy is safe and well tolerated, and may significantly prevent some chemotherapy-induced hematological toxicities in early breast cancer patients. These results should encourage further larger and more extensive clinical trials.
Articles from Integrative Cancer Therapies are provided here courtesy of SAGE Publications
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