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1 maart 2018: zie ook dit artikel:

31 januari 2017: zie ook het abstract van een review studie uit 2012 over de waarde van PSK - polysaccharide K (KRESTIN(®) bij vele vormen van kanker klik op volgende link - Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN®): review of development and future perspectives - waaronder vooral ook bij vormen van spijsverteringskanker, zoals darmkanker, rectumkanker, maagkanker enz..

En zie ook: Adjuvant immunochemotherapy with oral Tegafur/Uracil plus PSK in patients with stage II or III colorectal cancer: a randomised controlled study

Een persoonlijke opmerking hierbij: zouden alle mensen en organisaties die geld geven aan het KWF zich wel realiseren dat zelden of nooit geld gaat naar onderzoek naar dit soort niet toxische middelen en behandelingen?

15 maart 2005: Bron: Dis Colon Rectum. 1992 Feb;35(2):123-30.

Al eind jaren '80 onderzochten Japanse onderzoekers in een gerandomiseerd en dubbelblind onderzoek bij 462 darmkankerpatiënten het effect van PSK naast chemotherapie - 5/FU en Mytomycin C - na operatie. En ook toen al waren de resultaten significant beter voor de PSK groep: ziektevrije overleving: P = 0.013; overleving: P = 0.013. Toch vreemd dat in de westerse wereld, ook niet in Nederland nog nooit een gedegen fase II en III onderzoek is opgezet met PSK , want in vergelijking met Avastin zijn dit veel en veel betere cijfers voor darmkankerpatiënten en is in vele studies dit bewijs herhaald.

Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa).

Mitomi T, Tsuchiya S, Iijima N, Aso K, Suzuki K, Nishiyama K, Amano T, Takahashi T, Murayama N, Oka H, et al.

Department of Surgery II, Tokai University, Kanagawa, Japan.

A randomized, controlled trial of adjuvant immunochemotherapy with PSK (Kureha Chemical Industry Co., Tokyo, Japan) in curatively resected colorectal cancer was studied in 35 institutions in the Kanagawa prefecture. From March 1985 to February 1987, 462 patients were registered. Four hundred forty-eight of those patients (97.0 percent) satisfied the eligibility criteria. The control group received mitomycin C intravenously on the day of and the day after surgery, followed by oral 5-fluorouracil (5-FU) administration for over six months. The PSK group received PSK orally for over three years, in addition to mitomycin C and 5-FU as in the control group. At the end of February 1990, the median follow-up time for this study was four years (range, three to five years). The disease-free survival curve and the survival curve of the PSK group were better than those of the control group, and differences between the two groups were statistically significant (disease-free survival, P = 0.013; survival, P = 0.013). These results indicate that adjuvant immunochemotherapy with PSK was beneficial for curatively resected colorectal cancer.

PMID: 1735313 [PubMed - indexed for MEDLINE]

Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN®): review of development and future perspectives

Surg Today. 2012 Jan;42(1):8-28. Epub 2011 Dec 6.

Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives.


Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.


The mechanism of action of protein-bound polysaccharide K (PSK; KRESTIN(®)) involves the following actions: (1) recovery from immunosuppression induced by humoral factors such as transforming growth factor (TGF)-β or as a result of surgery and chemotherapy; (2) activation of antitumor immune responses including maturation of dendritic cells, correction of Th1/Th2 imbalance, and promotion of interleukin-15 production by monocytes; and (3) enhancement of the antitumor effect of chemotherapy by induction of apoptosis and inhibition of metastasis through direct actions on tumor cells. The clinical effectiveness of PSK has been demonstrated for various cancers. In patients with gastric or colorectal cancer, combined use of PSK with postoperative adjuvant chemotherapy prolongs survival, and this effect has been confirmed in multiple meta-analyses. For small-cell lung carcinoma, PSK in conjunction with chemotherapy prolongs the remission period. In addition, PSK has been shown to be effective against various other cancers, reduce the adverse effects of chemotherapy, and improve quality of life. Future studies should examine the effects of PSK under different host immune conditions and tumor properties, elucidate the mechanism of action exhibited in each situation, and identify biomarkers.

[PubMed - indexed for MEDLINE]



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