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27 augustus 2019: Bron: SAGE Journals

Afgelopen maand werd in SAGE Journals een overzichtsstudie gepresenteerd over de rol die cannabis - marihuana en afgeleide stofjes daarvan kunnen spelen in de zorg en behandeling van kankerpatienten: 

Opportunities for cannabis in supportive care in cancer

Het is volgens mij een uitstekend rapport en gratis te lezen of te downloaden.

Interessant is bv. dit hoofdstuk uit het rapport: 

Zo begint de introductie, klik op de nummers die verwijzen naar de referentielijst:

Cancer and cancer chemotherapy cause nausea and vomiting, pain, neuropathy, depression, sleep disorders, and other debilitating symptoms.1 These symptoms often develop during treatment and can persist after cessation of chemotherapy, severely impacting long-term quality of life.2 With more survivors than ever, and survivors living longer lives,3 it is important to address these symptoms to maximize survivors’ quality of life.

Despite limited randomized clinical trials, cannabis shows promise to improve many symptoms of cancer and its treatments.4,5 Social acceptance is also greatly increasing its use, despite lack of scientific evidence of safety and efficacy. In fact, in one community oncology clinic, 18.3% of patients with cancer reported using cannabis in 2017.6 In a Canadian study conducted in 2017, before cannabis was legalized in that country, 18% of patients with cancer used cannabis, often to relieve cancer-related pain, nausea, or other cancer symptoms.7 Unfortunately, although 80% of clinicians are discussing cannabis (i.e., medical marijuana) with patients, only 30% feel adequately informed to make recommendations about its use.8 It is crucial that scientific research on cannabis be accelerated to match patient demand. Only then will clinicians and patients have reliable safety and efficacy data to inform decisions that integrate information on patient symptoms, type of cannabis, delivery system, patient preference, dose, duration, and side-effects/adverse events.

This review describes how cannabis might modulate the most common and debilitating symptoms of cancer and its treatments in the context of cancer treatment, palliative care, and survivorship. While other reviews have examined the literature on medical cannabis related to cancer care (e.g., 4,5,912), we further explore cannabis in animal models and in other medical fields and cautiously extrapolate these findings to supportive and palliative care in cancer in humans. We urge patients and clinicians to recognize the potential drawbacks and dangers of cannabis, including allergic reactions, addiction/dependence, side effects, and interference with other medications. Nevertheless, we conclude that cannabis, in combination with guideline-based treatment regimens, tends to exhibit potential benefits that outweigh its risks.

We performed a review of the literature involving cannabis, cannabinoids, and marijuana for high priority symptoms of cancer and its treatments as identified by the National Cancer Institute Symptom Management and Quality of Life Steering Committee13: cognitive impairment, neurotoxicity, cardiovascular toxicity, fatigue, cancer-specific pain, sleep disorders, bone health toxicity, metabolic toxicity, and psychological distress. Chemotherapy-induced nausea and vomiting, loss of appetite/anorexia, and gastrointestinal (GI) distress were also included due to the historical use of cannabis for these cancer- and treatment-related ailments. The first author (A.S.K.) searched the PubMed database from the inception of the database to November 8, 2018. The results of this search are shown in Supplemental Table 1. Reference lists of recent review articles were also evaluated to identify additional trials. Only articles published in English were assessed, and results of clinical trials were prioritized.

Ik beperk me verder tot het abstract hier te vermelden omdat u zelf het studierapport kunt lezen waarin veel verwijzingen naar de referentielijst van 283 studies:

Hier het abstract: 

First Published August 1, 2019 Review Article 

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