4 februari 2020: bron: Journal of Crohn's and Colitis, Volume 14, Issue 1, January 2020, Pages 4–22,

Afgelopen week verschenen de nieuwe richtlijnen voor het behandelen van de ziekte van Crohn. Een darmaandoening waarbij sprake is van chronische ontstekingen. Het zijn zoveel opties tot behandelen dat ik alleen de link geef naar de richtlijnen. Daarin wel links naar studies enz.

De richtlijnen geven een compleet overzicht maar voor de gemiddelde patiënt zal een consult bij een arts wel noodzakelijk zijn. Of bij een goed gekwalificeerd complementair werkende arts want probiotica en synbiotica zijn vaak het effectiefst. Hier een search op onze website op ziekte van Crohn: https://kanker-actueel.nl/search.html?search_text=Crohn&search_in=title 

Het studierapport: 

ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment

is gratis in te zien.

Het artikel bevat de volgende onderwerpen:

Hier het abstract met ook referentielijst:

ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment 

Journal of Crohn's and Colitis, Volume 14, Issue 1, January 2020, Pages 4–22, https://doi.org/10.1093/ecco-jcc/jjz180

1. Introduction

Crohn’s disease is a chronic inflammatory bowel disease that can result in progressive bowel damage and disability.1 CD can affect individuals of any age, from children to the elderly,2,3 and may cause significant morbidity and impact on quality of life. Up to one-third of patients present with complicated behaviour [strictures, fistula, or abscesses] at diagnosis.4 Most patients over time will develop a complication, with roughly 50% of patients requiring surgery within 10 years of diagnosis.5–7 As the precise aetiology of CD remains unknown, a curative therapy is not yet available.8 Several agents are available for the medical treatment of CD. Medical agents include mesalazine [5-ASA], locally active steroids [such as budesonide], systemic steroids, thiopurines such as azathioprine and mercaptopurine , methotrexate , and biologic therapies (such as anti-tumour necrosis factor , anti-integrins, and anti-interleukin 12/23].

The European Crohn’s and Colitis Organisation produces and regularly updates several guidelines aimed at providing evidence-based guidance on critical aspects of IBD care to all health care professionals who manage patients with IBD. To provide high-quality evidence-based recommendations on medical treatment in CD, ECCO decided to develop these guidelines by adopting the GRADE [Grading of Recommendations Assessment, Development, and Evaluation] approach.9 GRADE is a systematic process for developing guidelines which addresses how to frame the health care questions, summarise the evidence, formulate the recommendations, and grade their strength and the quality of the associated evidence. GRADE increases transparency at all levels of this process and makes explicit the three considerations that lead to a particular recommendation: the quality of the evidence, the balance of benefits and harms, and the patients’ values and preferences. Therefore ECCO reviewed the available high-quality evidence on the medical management of CD and developed evidence-based recommendations on the medical treatment of adult patients with CD. These guidelines do not cover specific situations, such as postoperative management of adult patients with CD, which was already covered in the latest ECCO Guidelines on Crohn’s disease.10>>>>>>>lees verder

Author Contributions

JT, GF, MA, OZ coordinated the project; SB, TL, and MG-L advised on GRADE methodology, trained the working group members, and performed the analysis of data; GD, TK, JG, TR, AS, and JW coordinated the working groups; all the authors listed contributed to the identification of relevant data and data interpretation, and drafted and discussed the final recommendations; all the authors participated in the final Consensus; GF, JT, SB, GD, TK, JG, and TR drafted this manuscript; all authors, the ECCO Guideline Committee , and the ECCO Governing Board approved the final version of the manuscript.

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