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6 september 2019:

Recent is een nieuwe reviewstudie gepubliceerd over het New Castle Disease Virus bij de behandeling van kanker. Auteurs prof. dr. Volker Schirrmacher *, Dr. Stefaan van Gool en Wilfried Stuecker , allen werkzaam in het IOZK - Keulen. Zij werken al jaren met het Newcastle Disease Virus.

Klik op de titel van de studie voor het studierapport in PDF vorm: 

Breaking Therapy Resistance: An Update on Oncolytic Newcastle Disease Virus for Improvements of Cancer Therapy

Hier het abstract maar het studierapport is zeer uitgebreid. Zeker de moeite waard dit te lezen. 

Volker Schirrmacher *, Stefaan van Gool and Wilfried Stuecker Immune-Oncological Center Cologne (IOZK), D-50674 Cologne, Germany * Correspondence: V.Schirrmacher@web.de Received: 30 July 2019; Accepted: 23 August 2019; Published: 30 August 2019 Abstract: Resistance to therapy is a major obstacle to cancer treatment. It may exist from the beginning, or it may develop during therapy. The review focusses on oncolytic Newcastle disease virus (NDV) as a biological agent with potential to break therapy resistance. This avian virus combines, upon inoculation into non-permissive hosts such as human, 12 described anti-neoplastic effects with 11 described immune stimulatory properties. Fifty years of clinical application of NDV give witness to the high safety profile of this biological agent. In 2015, an important milestone was achieved, namely the successful production of NDV according to Good Manufacturing Practice (GMP). Based on this, IOZK in Cologne, Germany, obtained a GMP certificate for the production of a dendritic cell vaccine loaded with tumor antigens from a lysate of patient-derived tumor cells together with immunological danger signals from NDV for intracutaneous application. This update includes single case reports and retrospective analyses from patients treated at IOZK. The review also presents future perspectives, including the concept of in situ vaccination and the combination of NDV or other oncolytic viruses with checkpoint inhibitors.

24 juni 2016: Afgelopen week heb ik het IOZK bezocht ik samen met twee patiënten (hersentumoren) en hebben een uitvoerig gesprek gehad met dr. Stefan van Gool. Het was een open en prettig gesprek en ik zal komende week hier verslag van doen.

Allereerst lees ook dit studierapport:  Safety and Clinical Usage of Newcastle Disease Virus in Cancer Therapy

Onderaan abstract van deze studie met referentielijst.

Citaat uit dit studierapport:

The advantages of using NDV in cancer treatment are summarized as below.

  1. Ability of virus to bind to the tumor cell surface via its HN glycoprotein.
  2. Virus replicating in infected tumor cells leads to an enhanced expression of viral antigen on tumor cell surfaces.
  3. Ability of virus to induce synthesis of cytokines, like IFN and TNF, as well as stimulates production of heat shock proteins, adrenocorticotropic hormone, and tissue inhibitor of metalloproteases.
  4. Pleiotropic immunostimulatory effects of virus as the virus can augment the effects of T helper (TH) cells, cytotoxic T lymphocyte (CTL), NK cells, and macrophages.
  5. Oncolytic activity or direct killing of tumor cells in treated patients.
  6. Rapid growth of virus in tumor cells.
  7. The virus is not pathogenic to humans.

Onderstaande berichtgeving is nog steeds actueel. Het Newcastle Disease Virus en andere virussen worden meer en meer ingezet bij het bestrijden van kanker..  Als u hier klikt kunt u het volledige studierapport gratis inzien van een studie uit 2011. Met de titel: 

Safety and Clinical Usage of Newcastle Disease Virus in Cancer Therapy

1 januari 2005

Er wordt in Europa in verschillende klinieken en ziekenhuizen gewerkt met het Newcastle Disease Virus, Zie het abstract van de studie met het Newcastel Disease virus bij Glioblastoma Multiforme. Zie onder de videoknop linksboven ervaringen van kankerpatienten met complementaire aanpak, waarvan enkele ook het Newcastle Disease Virus hebben gebruikt samen met dendritische celtherapie

MTH-68/H , codenaam voor het Newcastle virus, lijkt de helft van de 14 deelnemende ongeneeslijke patiënten met een vergevorderde en uitbehandelde hersentumor / glioblastoma multiforme alsnog te genezen. Een zeer opmerkelijke en hoopgevende uitslag van dit al negen jaar lopende onderzoek.

Kleinschalige studie onder 14 patiënten met vergevorderde glioblastoma multiforme, hersentumoren, met het Newcastle virus / MTH-68/H geeft zeer opmerkelijke en spectaculaire resultaten. Maar liefst 4 patiënten leven nu al meer dan vijf tot zelfs negen jaar en alle vier de patienten leven een normaal leven zonder enige aanwijzing dat de Glioma / hersentumor terugkomt. Drie andere patiënten lijken ook in totale remissie maar de duur van hun behandeling is nog te kort om al definitieve conclusies te trekken. Nog opmerkelijker is dat al deze patiënten alle andere conventionele behandelingen zoals bestraling en operatie en zelfs chemo hebben gehad en steeds een recidief kregen. Vijf patiënten reageerden niet op het Newcastle virus en stierven aan de gevolgen van de groei van hun hersentumor. Twee patiënten stierven aan andere oorzaken. De onderzoekers schrijven er niet bij of dit een gevolg was van de behandeling met het Newcastle virus. Maar al met al een zeer hoopgevend bericht voor alle mensen met een hersentumor want de prognose van deze patienten is 6 maanden tot een jaar om hun hersentumor te overleven.

Bron: Pubmed

J Neurooncol. 2004 Mar-Apr;67(1-2):83-93. (Clinical Study, Abstract)

MTH-68/H oncolytic viral treatment in human high-grade gliomas L.K. Csatary, G. Gosztonyi, J. Szeberenyi, Z. Fabian, V. Liszka, B. Bodey and C.M. Csatary

United Cancer Research Institute, Alexandria, VA, USA (L.K.C., V.L., C.M.C.); Department of Neuropathology, University Clinics Benjamin Franklin, Freie Universitaet Berlin, Berlin, Germany (G.G.); Department of Medical Biology, School of Medicine, University of Pécs, Pécs, Hungary (J.S., Z.F.); Department of Pathology, Keck School of Medicine, University of Southern California (B.B.); Children’s Center for Cancer and Blood Diseases, Children’s Hospital, Los Angeles, CA, USA (B.B.). UCRI@aol.com

Application of virus therapy to treat human neoplasms has over a three decade history. MTH-68/H, a live attenuated oncolytic viral strain of the Newcastle disease virus, is one of the viruses used in the treatment of different malignancies. Here we report on the administration of MTH-68/H to patients with glioblastoma multiforme, the most common and most aggressive neuroectodermal neoplasm with a poor prognosis, averaging six months to a year. Four cases of advanced high-grade glioma were treated with MTH-68/H after the conventional modalities of anti-neoplastic therapies had failed. This treatment resulted in survival rates of 5-9 years, with each patient still living today. Against all odds, each patient resumed a lifestyle that resembles their previous daily routines and enjoys a good quality of life, Each of these patients has regularly received MTH-68/H as their sole form of onco-therapy for a number of years now without interruption.

PMID: 15072452

Onderstaande citaat is gehaald uit de volledige tekst van het studierapport met het Newcastle virus.

Our group first began to treat patients suffering from high-grade glioma with MTH-68/H viral therapy in 1996. Altogether 14 high-grade glioma patients have been treated. In five patients, the viral therapy did not arrest tumor progression; they died demonstrably as the direct result of their tumor growth. Two patients died of causes unrelated to their brain neoplasm. Seven out of the 14 treated patients are still alive. In three of these patients, the results are promising, however, the duration of their MTH-68/H treatment (4–18 months) has not yet been long enough to allow reliable evaluation. The remaining four patients received MTH-68/H therapy for a duration of 4–7 years and their survival times, up to the present, reach between 5 and 9 years. None of these glioma patients experienced any adverse events throughout their course of treatment. These four high grade glioma patients, who have received MTH-68/H as their sole form of non-surgical onco-therapy over a span of years, have not only survived but have been able to enjoy a good quality of life, with either limited or no detectable sign of tumor progression. These four patients are the subject of this report.

Based on all the previous research, NDV is safe and feasible to be used as a therapeutic agent. More systemic investigations are necessary to enhance the quality and efficacy of NDV vaccine. Further testing or even preparation of a DNA vaccine may be required to confirm the safety of virus administration and to improve the public's acceptance. In short, NDV can be a potential alternative adjuvant in cancer treatment.

J Biomed Biotechnol. 2011; 2011: 718710.
Published online 2011 Oct 26. doi:  10.1155/2011/718710
PMCID: PMC3205905

Safety and Clinical Usage of Newcastle Disease Virus in Cancer Therapy

Han Yuen Lam, 1 Swee Keong Yeap, 2 Mehdi Rasoli, 2 Abdul Rahman Omar, 2 Khatijah Yusoff, 3 Abd Aziz Suraini, 4 and Noorjahan Banu Alitheen 1 ,*
Author information ► Article notes ► Copyright and License information ►
This article has been cited by other articles in PMC.

Abstract

Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, especially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV strains applied for cancer immunotherapy is also discussed in this paper.

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hersentumoren, glioblastoom multiforme, Newcastle Disease Virus


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