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20 november 2022:  2022 Nov 12;12(1):19397

Vitamine D suppletie vermindert de kans op een besmetting en overlijden aan het coronavirus (Covid-19) binnen 30 dagen met 25 tot 33 procent . Dat bewijst een groot Amerikaans onderzoek uitgevoerd via de gegevens uit de database van Amerikaanse veteranen. 

Opnieuw bewijst dus een grote studie de meerwaarde van vitamine D suppletie in het voorkomen van een besmetting met het coronavirus (Covid-19)  en minder kans op overlijden aan een besmetting met het coronavirus (Covid-19) en bevestigt met dezelfde resultaten als een gerandomiseerde Israelische studie uit februari 2022. 

Zo gingen de onderzoekers te werk, vertaald uit het studierapport:

We hebben een retrospectieve cohortstudie uitgevoerd om het verband tussen vitamine D3- en D2-suppletie en COVID-19-infectie en mortaliteit te bepalen. We schatten de associatie met behulp van een cohort van VA-patiënten die suppletie kregen met ergocalciferol (d.w.z. vitamine D2), doxercalciferol (d.w.z. vitamine D2), oraal cholecalciferol (d.w.z. vitamine D3) of calcifediol (d.w.z. vitamine D3) voor een periode vóór de pandemie (d.w.z. 1 januari 2019 – 31 december 2020) en tijdens de pandemie (d.w.z. 1 maart 2020 – 31 december 2020) en onbehandelde controlepatiënten.
Voorafgaand aan de schatting hebben we behandelde en controlepatiënten één op één gematcht op hun gebruik van suppletie afzonderlijk voor vitamine D3 en D2. Vervolgens hebben we Cox-modellen voor proportionele risico's gebruikt om de tijd tot COVID-19-infectie en mortaliteit binnen 30 dagen na infectie te berekenen, afhankelijk van suppletie.
We hebben ook subgroepanalyses uitgevoerd voor D3 om de heterogeniteit van de behandeling te bepalen per ras (zwart versus blank), vitamine D-spiegel (0–19 ng/ml, 20–39 ng/ml en 40 + ng/ml 25-dihydroxycholecalciferol), en gemiddelde dagelijkse en cumulatieve suppletiedosering. De kleinere omvang van de D2-dataset maakte subgroepanalyses onmogelijk.

Hier de vertaling van de belangrijkste conclusies uit het abstract van de Amerikaanse studie:
  • In de populatie van Amerikaanse veteranen laten we zien dat vitamine D2- en D3-vullingen geassocieerd waren met een vermindering van COVID-19-infectie van respectievelijk 28% en 20% [(D3 Hazard Ratio (HR) = 0,80, [95% BI 0,77, 0,83 ]), D2 HR = 0,72, [95% BI 0,65, 0,79]].
  • Sterfte binnen 30 dagen na COVID-19-infectie was eveneens 33% lager met vitamine D3 en 25% lager met D2 (D3 HR = 0,67, [95% BI 0,59, 0,75]; D2 HR = 0,75, [95% BI 0,55, 1.04]).
  • We vinden ook dat veteranen die hogere doseringen vitamine D kregen, na controle op vitamine D-bloedspiegels, meer baat hadden bij suppletie dan veteranen die lagere doseringen kregen. Veteranen met vitamine D-bloedspiegels tussen 0 en 19 ng/ml vertoonden de grootste afname van COVID-19-infectie na suppletie.
  • Zwarte veteranen kregen grotere geassocieerde COVID-19-risicoverminderingen met suppletie dan blanke veteranen.


See this image and copyright information in PMC
Figure 2 
Kaplan Meier curves for vitamin D3 and D2 supplement patients versus control—time-to COVID-19 infection ending in mortality within 30-days.


Het volledige studierapport is gratis in te zien of te downloaden. Klik daarvoor op de titel van het abstract:

Vitamine D is een veilige, algemeen beschikbare en betaalbare behandeling en kan de ernst van de COVID-19-pandemie helpen verminderen. 

Het volledige studierapport is gratis in te zien of te downloaden. Klik daarvoor op de titel van het abstract:

. 2022 Nov 12;12(1):19397.
 doi: 10.1038/s41598-022-24053-4.

Association between vitamin D supplementation and COVID-19 infection and mortality

Jason B Gibbons 1 2, Edward C Norton 3 4 5, Jeffrey S McCullough 5, David O Meltzer 6, Jill Lavigne 7 8, Virginia C Fiedler 9, Robert D Gibbons 6 10
Affiliations 
Free PMC article

Abstract

Vitamin D deficiency has long been associated with reduced immune function that can lead to viral infection. Several studies have shown that Vitamin D deficiency is associated with increases the risk of infection with COVID-19. However, it is unknown if treatment with Vitamin D can reduce the associated risk of COVID-19 infection, which is the focus of this study. In the population of US veterans, we show that Vitamin D2 and D3 fills were associated with reductions in COVID-19 infection of 28% and 20%, respectively [(D3 Hazard Ratio (HR) = 0.80, [95% CI 0.77, 0.83]), D2 HR = 0.72, [95% CI 0.65, 0.79]]. Mortality within 30-days of COVID-19 infection was similarly 33% lower with Vitamin D3 and 25% lower with D2 (D3 HR = 0.67, [95% CI 0.59, 0.75]; D2 HR = 0.75, [95% CI 0.55, 1.04]). We also find that after controlling for vitamin D blood levels, veterans receiving higher dosages of Vitamin D obtained greater benefits from supplementation than veterans receiving lower dosages. Veterans with Vitamin D blood levels between 0 and 19 ng/ml exhibited the largest decrease in COVID-19 infection following supplementation. Black veterans received greater associated COVID-19 risk reductions with supplementation than White veterans. As a safe, widely available, and affordable treatment, Vitamin D may help to reduce the severity of the COVID-19 pandemic.

Conflict of interest statement

Dr. DO Meltzer reported grants from the National Institutes of Health during the conduct of the study. Dr. JB Gibbons, Dr. J Lavigne, Dr. VC Fiedler, Dr. EC Norton, Dr. J McCullough, Dr. RD Gibbons have no conflicts to report.

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