30 mei 2021: Bron: 2017 Jan 9;17(1):40

Uit een gerandomiseerde studie blijkt dat acupunctuur naast Methylcobalamine = actieve vorm van B12 bij patiënten met multiple myeloma (botkanker - Kahler) door chemo veroorzaakte  perifere neuropathie en de pijn  verbetert in vergelijking met alleen Methylcobalamine.

De 104 patiënten met multiple myeloma (Kahler - botkanker) die aan de inclusiecriteria voldeden, werden willekeurig toegewezen aan een groep die alleen methylcobalamine kreeg (500 μg intramusculaire methylcobalamine-injecties om de dag gedurende 20 dagen; tien injecties) gevolgd door 2 maanden van 500 μg orale toediening van methylcobalamine, driemaal per dag) en een groep die daarnaast acupunctuur kreeg gecombineerd met methylcobalamine (Met + Acu) groep (methylcobalamine werd op dezelfde manier gebruikt als in de andere groep plus  drie acupunctuurcycli). Van de patiënten voltooiden 98 van de 104 de behandeling en follow-ups. Er waren 49 patiënten in elke groep.

Na 84 dagen behandelingen (drie kuren) was de pijn significant verlicht in beide groepen, met een significant hogere afname in de met acupunctuur behandelde groep (P <0,01).

Het volledige studieverslag is gratis in te zien met gedetailleerde beschrijvingen en grafieken. Klik op de titel van het abstract voor het studieverslag.



Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy. Acupuncture has a potential role in the treatment of CIPN, but at present there have been no randomized clinical research studies to analyze the effectiveness of acupuncture for the treatment of CIPN, particularly in MM patients.


The MM patients (104 individuals) who met the inclusion criteria were randomly assigned into a solely methylcobalamin therapy group (500 μg intramuscular methylcobalamin injections every other day for 20 days; ten injections) followed by 2 months of 500 μg oral methylcobalamin administration, three times per day) and an acupuncture combined with methylcobalamin (Met + Acu) group (methylcobalamin used the same way as above accompanied by three cycles of acupuncture). Of the patients, 98 out of 104 completed the treatment and follow-ups. There were 49 patients in each group. The evaluating parameters included the visual analogue scale (VAS) pain score, Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire scores, and electromyographic (EMG) nerve conduction velocity (NCV) determinations. We evaluated the changes of the parameters in each group before and after the therapies and made a comparison between the two groups.


After 84 days (three cycles) of therapy, the pain was significantly alleviated in both groups, with a significantly higher decrease in the acupuncture treated group (P < 0.01). The patients’ daily activity evaluated by Fact/GOG-Ntx questionnaires significantly improved in the Met + Acu group (P < 0.001). The NCV in the Met + Acu group improved significantly while amelioration in the control group was not observed.


The present study suggests that acupuncture combined with methylcobalamin in the treatment of CIPN showed a better outcome than methylcobalamin administration alone.

Trial registration

China Clinical Trials Register (registration no. ChiCTR-INR-16009079

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