13 september 2016: Bron: Nutrition. 2016 Jun;32(6):681-6. doi: 10.1016/j.nut.2015.12.028. Epub 2015 Dec 29

Foliumzuur 5 gr. per dag en dat een half jaar lang voorkomt beter verdere groei en brengt reeds aanwezige  kwaadaardige tumorcellen in de baarmoeder vaker in remissie in vergelijking met een placebo 83.3% versus 52.0%, P = 0.019. Ook blijken bepaalde bloedwaarden: zoals insuline waarden, HOMA-B, plasma MDA en plasma GSH waarden die min of meer gerelateerd zijn aan beginnende baarmoederkanker te verbeteren door de foliumzuur.

Dit blijkt uit een dubbelblinde gerandomiseerde placebo gecontroleerde studie bij totaal 58 vrouwen.

Conclusion: Taken together, folate supplementation (5 mg/d) for 6 mo among women with CIN1 resulted in its regression as well as led to decreased serum insulin, HOMA-B, plasma MDA and increased plasma GSH levels

cervical-cancer-s2-illustration-of-cervical-cancer

Bron foto: http://www.medicinenet.com/cervical_cancer_pictures_slideshow/article.htm

At the very early stages of cervical cancer, there are usually no symptoms or signs. As the cancer grows, symptoms can include abnormal vaginal bleeding. Abnormal vaginal bleeding is bleeding that occurs between periods, during sex, or after menopause. Pain during sex and vaginal discharge are other possible symptoms.

Het abstract is heel summier, zie hieronder en voor het volledige studierapport: Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial moet worden betaald.

Maar het is m.i. toch wel opmerkelijk dat met 5 gr. foliumzuur per dag baarmoederkanker blijkbaar grotendeels kan worden voorkomen, zelfs als er al kwaadaardige tumorcellen aanwezig zijn.

Ik vraag me dan wel af wanneer je daarmee zou moeten beginnen? Wat waren de basiswaarden van de vrouwen of is foliumzuur altijd goed om te nemen? Vraag dat aub aan een goed gekwalificeerd arts die hier meer verstand van heeft dan ik.

Hier het abstract van de studie:

Taken together, folate supplementation (5 mg/d) for 6 mo among women with CIN1 resulted in its regression as well as led to decreased serum insulin, HOMA-B, plasma MDA and increased plasma GSH levels

Nutrition. 2016 Jun;32(6):681-6. doi: 10.1016/j.nut.2015.12.028. Epub 2015 Dec 29.

Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial.

Asemi Z1, Vahedpoor Z2, Jamilian M3, Bahmani F1, Esmaillzadeh A4.

Author information

  • 1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.
  • 2Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran.
  • 3Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran; Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
  • 4Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: esmaillzadeh@hlth.mui.ac.ir.

Abstract

OBJECTIVE:

This study was conducted to determine the effects of long-term folate supplementation on regression and metabolic status of patients with cervical intraepithelial neoplasia grade 1 (CIN1).

METHODS:

This randomized, double-blind, placebo-controlled trial was performed among 58 women diagnosed with CIN1, ages 18 to 55 y old. Participants were randomly divided into two groups to receive 5 mg/d folate supplements (n = 29) or placebo (n = 29) for 6 mo. Fasting blood samples were taken at baseline and 6 mo after intervention to quantify related markers.

RESULTS:

A greater percentage of women in the folate group had regressed CIN1 (83.3 versus 52.0%, P = 0.019) than those in the placebo group. Long-term folate supplementation resulted in a significant decrease in serum insulin levels (-1.6 ± 6.2 versus +2.6 ± 6.9 μIU/mL, P = 0.018) and homeostatic model assessment-beta cell function (HOMA-B) (-13.0 ± 39.0 versus +11.2 ± 42.3, P = 0.028) compared with the placebo. Additionally, plasma glutathione (GSH) levels were significantly increased (+81.5 ± 264.1 versus -220.9 ± 342.5 μmol/L, P < 0.001) and malondialdehyde (MDA) levels were significantly reduced (-1.0 ± 1.1 versus +0.1 ± 1.6 μmol/L, P = 0.004) in the folate group compared to the placebo.

CONCLUSIONS:

Taken together, folate supplementation (5 mg/d) for 6 mo among women with CIN1 resulted in its regression as well as led to decreased serum insulin, HOMA-B, plasma MDA and increased plasma GSH levels; however, it did not affect other metabolic profiles.

Copyright © 2016 Elsevier Inc. All rights reserved.

hyperthermie, bestraling, radiotherapie, baarmoederkanker, baarmoederhalskanker, ziektevrije tijd, kans op recidief, radiochemotherapie, preventie, overall overleving, gerandomiseerde studie, foliumzuur


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