20 februari 2011: Bron: Acta Oncol. 2011 Feb;50(2):167-78. Epub 2010 Nov 24.
Wie succesvol is behandeld met kanker kan een recidief voorkomen om alsnog gezond te gaan leven en te letten op lichaamsgewicht, voeding, regelmatig bewegen en weinig alcohol te gebruiken. Dit blijkt uit een meta analyse van 21 gerandomiseerde studies van de afgelopen drie jaar. We plaatsen hier het abstract van deze meta analyse maar als u het volledige studierapport wilt lezen klik dan hier met grafieken enz. Wel allemaal in het Engels maar toch duidelijk beschreven en een bevestiging van wat al jaren bekend is. Een recidief van kanker is te voorkomen of langer uit te stellen door uw levensstijl aan te passen. Het maakt echt veel verschil als u let op een aantal dingen.
Updated evidence in support of diet and exercise interventions in cancer survivors
February 2011, Vol. 50, No. 2 , Pages 167-178 (doi:10.3109/0284186X.2010.529822)
University of Alabama at Birmingham, Birmingham, Alabama, USA
Correspondence: Wendy Demark-Wahnefried, NP 2514, 1530 3rd Ave South, Birmingham, Alabama 35294-3360, USA. Tel: +1 205 975 4022. Fax: +1 205 934 7049. E-mail: firstname.lastname@example.org
Background. A growing body of evidence suggests that diet and exercise behaviors and body weight status influence health-related outcomes after a cancer diagnosis. This review synthesizes the recent progress in lifestyle interventions in light of current guidelines put forth by the American Cancer Society (ACS), the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and the American College of Sports Medicine (ACSM). Methods. The PubMed database was searched for terms of cancer survivor(s) or neoplasms/survivor, cross-referenced with MeSH terms of lifestyle, health behavior, physical activity, exercise, body weight, obesity, weight loss, diet, nutrition, and intervention studies and limited to randomized controlled trials (RCTs) that had retention rates exceeding 75%. Results. There has been an increase in the number and methodological rigor of the studies in this area, with 21 RCTs identified in the past three years. Results suggest that physical activity interventions are safe for cancer survivors and produce improvements in fitness, strength, physical function, and cancer-related psychosocial variables, whereas dietary interventions improve diet quality, nutrition-related biomarkers and body weight. Preliminary evidence also suggests that diet and exercise may positively influence biomarkers associated with progressive disease and overall survival (e.g., insulin levels, oxidative DNA damage, tumor proliferation rates). Discussion. The evidence base regarding health-related benefits of increased physical activity, an improved diet, and weight control continues to expand. Due to the large (and increasing) number of cancer survivors, more research is needed that tests the impact of lifestyle change on health-related outcomes in this population, especially research that focuses on high-reach, sustainable interventions that recruit diverse, representative samples to help increase the generalizability of findings to the population at large. Concurrent research also needs to address relative benefit in relation to various subpopulations as defined by phenotype, genotype, and/or exposures to treatment, and other lifestyle and environmental factors.
According to the most recent 2008 compilation of cancer statistics by the International Agency for Cancer Research through the GLOBOCAN Project, there were 12.7 million new cancer cases and 7.6 million cancer deaths worldwide . With continual advances in early detection and treatment, the differential between cancer incidence and mortality is ever-expanding, and with each passing year the number of cancer survivors increases dramatically. Five years ago, Parkin and colleagues reported that the number of cancer survivors in the world totaled over 24.5 million ; today, the number is far greater. Although these statistics are encouraging, it is important to acknowledge that the impact of cancer is significant and associated with several long-term health and psychosocial sequelae . In addition to risk for recurrence, data clearly show that compared with general age- and race-matched populations, cancer survivors are at greater risk for developing second malignancies, cardiovascular disease, diabetes, osteoporosis, and functional decline . These comorbid conditions and competing causes of death and disability are believed to result from cancer treatment, genetic predisposition, and/or common lifestyle factors .
Lifestyle interventions that promote improvements in diet and exercise behaviors have been proposed as a means to ameliorate the adverse effects of cancer and its treatment . Various organizations, such as the American Cancer Society (ACS), the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and most recently, the American College of Sports Medicine (ACSM) have issued guidelines for diet and/or physical activity that target cancer survivors [4–6]. These reports serve as resources for health care providers, patient advocates, and other stakeholders to improve the health and well-being of this rapidly expanding and high risk population. Table I features excerpts of these compiled guidelines (note that recommendations for alcohol have been omitted since this review is focused solely on diet and exercise). It should be noted, however that each of these reports points to the relative dearth of data on which their current recommendations rest – thus, the infusion of new data is exceptionally important in order to improve our knowledge of the potential benefits of lifestyle change after the diagnosis of cancer, as well as to gain an understanding of the optimal means for promoting behavioral change in this patient population. The goal of this paper is to review these recommendations in light of recent studies that have emerged within the past few years.
- K-Ras kankercellen die ongevoelig lijken voor reguliere behandelingen, zelfs voor immuuntherapie zijn afhankelijk van de beschikbaarheid van glucose en glutamine. Dr. Otto Warburg benadrukte dit al in zijn onderzoeken
- Algemeen: een intensief fitness programma onder deskundige begeleiding verbetert fysiek en psychologisch functioneren bij overlevenden van kanker, zowel op korte- als lange-termijn bewijst nieuw onderzoek
- Algemeen: Nieuw bewijs dat een gezonde leefstijl met regelmatig bewegen, weinig alcohol, niet roken en gezond eten met veel groenten en fruit een recidief van kanker kan voorkomen
- Algemene artikelen over complementaire bewezen middelen en behandelingen