Enkele koppen koffie per dag vermindert het risico op primaire leverkanker met ca. 50% blijkt uit epidemologische studie onder 100.000 Japanse volwassenen over een periode van tien jaar. Opvallend is altijd geweest dat primaire leverkanker in Azië veel meer voorkomt dan in Westerse landen. Zover wij weten wordt in westerse landen ook veel meer koffie gedronken dan in Aziatische landen. Misschien is hierin een verband te leggen. Wie leest onder leverreiniging onder deze artikelen ziet dat een koffieklisma op zijn tijd ook voor verlichting kan zorgen bij mensen met levertumoren. Of hier verband bestaat tussen koffie te gebruiken als hulp bij klisma's of op andere manieren klisma's te gebruiken durven we niet te zeggen maar wat let u als u toch regelmatig een klisma uitvoert om daarvoor koffie te gebruiken. Doe dit wel altijd onder deskundige begeleiding a.u.b. Verschillende orthomoleculaire artsen kunnen u daarin goed begeleiden, al is niet iedereen daarin gespecialiseerd. Dus vraag dit wel goed na bij de geraadpleegde arts dat u specifiek over klisma's informatie en begeleiding wilt hebben. Hier eerst het abstract van de studie en daarna het artikel uit Nutraingredients over deze studie.
J Natl Cancer Inst. 2005 Feb 16;97(4):293-300.
Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan.
Inoue M, Yoshimi I, Sobue T, Tsugane S; JPHC Study Group.
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 Japan. firstname.lastname@example.org
BACKGROUND: An association between coffee drinking and reduced risk of liver cancer has been suggested by animal studies, but epidemiologic evidence of such an association in a high-risk population is lacking. We conducted a large-scale population-based cohort study of the association between coffee drinking and hepatocellular carcinoma (HCC) in a Japanese population.
METHODS: Newly diagnosed case patients (250 men and 84 women) with HCC were identified from a 10-year follow-up of the Japan Public Health Center-based Prospective Study, which consists of 90,452 middle-aged and elderly Japanese subjects (43,109 men and 47,343 women). Case patients were grouped according to coffee intake and were stratified by hepatitis virus infection, sex, age, diet, lifestyle factors, and previous history of liver disease. Multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CIs) for HCC were calculated with Cox proportional-hazards modeling. All statistical tests were two-sided.
RESULTS: Subjects (men and women combined) who consumed coffee on a daily or almost daily basis had a lower HCC risk than those who almost never drank coffee (HR = 0.49 [95% CI = 0.36 to 0.66]); risk decreased with the amount of coffee consumed (compared with nondrinkers, the HR for 1-2 cups per day = 0.52 [95% CI = 0.38 to 0.73]; for 3-4 cups per day = 0.48 [95% CI = 0.28 to 0.83]; for > or =5 cups per day = 0.24 [95% CI = 0.08 to 0.77], P(trend) < .001). The risk of liver cancer in almost never drinkers in this population was 547.2 cases per 100,000 people over 10 years, but it was 214.6 cases per 100 000 people with drinking coffee on a daily basis. The inverse association persisted when the participants were stratified by lifestyle factors. Similar associations were observed when the analysis was restricted to hepatitis C virus-positive patients (all daily drinkers compared with nondrinkers: HR =0.57 [95% CI = 0.37 to 0.86]), to hepatitis B virus-positive patients (HR = 0.60 [95% CI = 0.31 to 1.18]) and to subjects with no past history of chronic liver disease (HR = 0.45 [95% CI = 0.30 to 0.67]).
CONCLUSIONS: In the Japanese population, habitual coffee drinking may be associated with reduced risk of HCC.
PMID: 15713964 [PubMed - in process]
Hier artikel uit nutraingredients:
16/02/2005 - Benefits and risks of coffee drinking on consumer health are the focus of two new studies that ultimately reveal the positive, or negligible impact, of this popular beverage. One study found that daily drinking coffee could cut the risk of liver cancer, while the other found no association between drinking coffee or tea, and the risk of colorectal cancer. Coffee consumption is common throughout the world, with retail sales hitting over €54 billion. And scientists continue to explore the impact it may have on human health. The first study, published in the 16 February issue of the Journal of the National Cancer Institute, found that people who drank coffee on a daily or almost daily basis had about half the risk of developing hepatocellular carcinoma (HCC: a type of liver cancer) compared with those who never drank coffee. According to researchers at the National Cancer Center in Tokyo that carried out the study, the rate of liver cancer among those who never drank coffee was 547.2 cases per 100,000 people over 10 years. Among daily coffee drinkers the rate was almost fifty per cent less, at about 214.6 cases per 100,000 people. Of particular interest, the risk of HCC decreased with an increase in the amount of coffee consumed each day. But the authors caution that because decaffeinated coffee is rarely consumed in Japan, and therefore no distinction was made between caffeinated and decaffeinated coffee, they were unable to determine if caffeine was responsible for the decreased risk of HCC. “ Further studies are warranted to assess whether the present results can be generalised or are representative of other populations," say the researchers. In the second study, Karin B. Michels and colleagues at Brigham and Women's Hospital in Boston, explored the association between coffee, tea, and caffeine consumption and the incidence of colorectal cancer. They used data from two large prospective studies (the Nurses' Health Study (women) and the Health Professionals' Follow-up Study (men)), that totalled almost 2 million person years of follow-up. The researchers report that they found no association between consumption of caffeinated coffee or tea and the incidence of colon or rectal cancer in either group. But suggesting the benefits of decaff consumption, study participants who regularly drank two or more cups per day of decaffeinated coffee, had about half the incidence of rectal cancer compared with those who never drank decaffeinated coffee. The authors caution that this observed association may be due to differences in lifestyle; because drinkers of decaffeinated coffee might be more health conscious in their behaviour than those who consume caffeinated coffee. They recommended new studies to confirm the decaffeinated vesus caffeine findings. After being dogged in recent years by poor prices following a glut in coffee production, prices are just starting to recover for the global industry. A surge in Arabica prices recorded during the last quarter of 2004 continued into January 2005. According to the International Coffee Organisation, most of January’s Arabica transactions involved price levels of over US107 cents/lb compared to below US 70 cents/lb a year ago.