15 april 2012: ik heb in onderstaand artikel enkele veranderingen aangebracht omdat de verwijzingen naar adressen niet meer klopte. Onderaan referentielijst zoals die op Wikipedia wordt gepubliceerd.

Woord vooraf: In The health benefits of medicinal mushrooms from Mark Stengler een Engelstalig boek over medicinale paddestoelen wordt beschreven hoe de paddestoelen moeten worden klaargemaakt en gegeten. Raadpleeg wel altijd een deskundig arts hiervoor

Op Wikipedia kunt u veel over de Maitake champignon lezen zoals onderstaand artikel. Het lijkt erop dat juist de stofjes beta-glucan 1.3 en 1.6 , onderdeel van de Maitake verantwoordelijk zijn voor de immuunstimulerende functie van deze medicinale champignon.  Hier een engelstalige beschrijving van wat Maitake precies is en hoe het werkt.


Maitake (Grifola frondosa) is the Japanese name for an edible fungi with a large fruiting body characterized by overlapping waves. Maitake is derived from the Japanese, "mai" meaning dance and "take" meaning mushroom, thus many refer to Maitake as the "dancing mushroom". It is a premier culinary mushroom as well as a medicinal mushroom. Though mushrooms in general are not particularly known for being nutrient-dense, medicinal mushrooms such as maitake are increasingly being recognized as a potent source of various compounds with diverse biological and therapeutic effects with dramatic health-promoting properties. 
Within the past two decades, maitake has begun to be cultivated not just as a food but also as a dietary supplement that may significantly benefit overall health. It very well may be the most versatile and promising medicinal mushroom supplement, though currently less well-known than shiitake and reishi. Andrew Weil has said that maitake appears to be the most effective immune-boosting mushroom of all, noting that it belongs to the polypore family of medicinal mushrooms that, in the Far East, includes many mushrooms that "are highly esteemed as medicinal herbs, especially the class of superior drugs, the tonics and panaceas that increase resistance and promote longevity." Such adaptogens are often taken on a daily basis to help balance bodily functions and prevent disease. 

To an extent, the content and bioactivity of these compounds depend on how the mushroom is prepared and consumed. Among the most important constituents, however, are certain polysaccharides known as the beta-glucans. Maitake's prominent immune-boosting effects are thought to be due predominantly to these polysaccharides. 

Polysaccharides such as the beta glucans found in a number of medicinal mushrooms (as well as other polysaccharides found in medicinal herbs) are increasingly being recognized for their ability to have a non-specific immune-modulation effect. These so-called biological response modifiers can be potent anti-viral and anti-tumor agents, not by killing viruses or cancer cells directly but by stimulating the body's innate ability to marshal cellular defenses. The maitake mushroom contains a high percentage of beta glucan. While other medicinal mushrooms have also been shown to possess bioactive beta-glucan constituents, researchers have noted that their various beta glucan characteristics differ. Maitake's beta 1/6, 1/3 glucan has superior immune activity compared to other medicinal mushrooms previously studied. Other medicinal mushrooms contain a 1/3, 1/6 glucan. According to researchers, "despite the structural and functional similarities of these glucans, they differ in their effectiveness against specific tumors and in their ability to elicit various cellular responses, particularly cytokine expression and production". One theory is that the greater the degree of branching the higher the likelihood that the fraction will reach and activate many more immune cells. One top microbiologist has been quoted as saying, "most of the mushrooms contain similar polysaccharides but I believe that Maitake is the most potent". While the role of medicinal mushrooms in cellular and immune health is strong, one of the challenges with medicinal mushrooms is that many of them lose much of their effectiveness when taken orally. A number of studies have shown that Maitake is the most effective of the medicinal mushrooms when taken orally. 

In the late 1980's certain researchers in Japan began to develop reliable and consistent methods for extracting certain portions of the maitake mushroom which is responsible for the immune stimulation activity. The prime researcher in this area was Dr. Hiroaki Nanba of Kobe Pharmaceutical University. Dr. Nanba obtained various extracts from the maitake by continuously refining down the elements in the fruit body of Maitake which led to his creation of an extract called D Fraction. Dr. Nanba published the results of his D fraction research in 1988. Throughout the 1990's Dr. Nanba endeavored to improve upon the immuno-potentiating activity of the D fraction extract in order to provide greater concentration of the key beneficial compounds for efficient use in dietary supplements. As Dr. Nanba researched the D Fraction extract further he discovered an adhering substance or "float" that actually inhibited the immuno potentiating activity of the extract. Dr. Nanba was able to remove the float which led to a more powerful and more pure maitake extract than the D fraction. This advanced extract is called MD Fraction. This MD Fraction extract is the maitake extract that consumers should search for, since other look-alikes are simply less potent, first generation fractions, developed more than a decade ago.

It is important to note that any research references to the D fraction also apply to the more advanced MD Fraction, as they are the same beta 1/6, 1/3 glucan derived from Grifola frondosa. MD Fraction is a next generation maitake extract from the D fraction and is more potent than the old D fraction extract. 



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Plaats een reactie ...

3 Reacties op "De medicinale paddestoel Maitake MD-fraction , waarom dit natuurlijke middel zo bijzonder is in een behandeling van kanker"

  • Hans :
    Ik kwam onderstaande tekst tegen bij het zoeken naar achtergrondinformatie, dit lijkt me goed om te weten voor iedereen die het in deze hoek zoekt.
    Laat u geen knollen voor citroenen verkopen !!

    Alle informatie is juist en kan eenvoudig via Google worden geverifieerd (ik heb dat gedaan!)
    Let’s list the facts:

    – In 1984 Prof. Nanba patented the production process of what later became known as the D-fraction. The actual term ‘D-fraction’ was introduced by Prof. Nanba in the 1980s in his research papers.

    – In 1991 two Wall-Street businessmen started Maitake Products, Inc. (MPI)

    – In 1995 they trademarked the phrase ‘D-fraction’ and introduced Grifron-Pro Maitake D-Fraction®, a liquid product consisting of “900mg pure Maitake D-fraction extract in a 1 fluid oz. bottle (sic)”

    – In 1997 Professor Nanba optimized the fractionation process of the D-fraction; the result was patented and became known as the MD-fraction.

    – In 1998 MPI ’s flagship product, Grifron-Pro Maitake D-Fraction® was given an Investigational New Drug (IND) status by the U.S. FDA in order to conduct a Phase II pilot study on the treatment of advanced breast and prostate cancer. Oddly enough, there is no information available at all about the outcome of this pilot study, and the product in question has been renamed a few years later. When asked about the trial’s outcome, the company said this was ‘proprietary information’ only available to ‘qualified persons’.

    – In 2002 the Tradeworks Group, acting as a representative of Yukiguni, the worlds biggest producer of Maitake at the time (and funding Prof. Nanba ’s research) lauched their MaitakeGold404® product, using science-based marketing similar to MPI’s approach.

    – Late 2002 MPI sued the Tradeworks Group stating “Tradeworks […] advertised their products as the extract used in clinical studies on D-fraction (a beta glucan). “Our D-Fraction has been the base for almost all science of maitake mushroom for the last 12 to 15 years” (Mike Shirota, CEO of MPI)

    – Early 2003 the Tradeworks Group countersued MPI stating “MPI represented that it ‘coined the term D-fraction,’ despite knowing and indeed acknowledging in the complaint that Dr. Hiroaki Nanba defined the D-fraction maitake extract, in published scientific articles, before MPI even existed”, adding that “MPI […] altered [research] articles to support its claims for their Maitake D-Fraction product”

    – It is indeed unclear, not to say ‘questionable’ whether the product(s) MPI sell actually contain purified ‘D-fraction’ as described in Nanba’s publications.The specifications of their alleged D-Fraction-containing supplementsall state ‘Maitake PD-Fraction® Standardized to contain 30% proteoglucan;’, where ‘PD-Fraction’ stands for ‘Pre-D-fraction’. What ‘Pre-D’ actually is, is not further explained: is it A-, B- or C-fraction ? Or something else? Based on their own description, it is not pure D-fraction.

    When asked for a Certificate of Analysis the company states this is ‘proprietary information’. A direct question: “Is your D-fraction identical to prof. Hiroaki Nanba’s D-fraction as described in [….]” remains unanswered, even after repeated attempts.
  • Vernon :
    Beste Vernon,
    Ik heb uw reactie weggehaald omdat u zonder enig bewijs zware beschuldigingen doet aan iedereen die Maitake D-fraction verkoopt. U zult met meer en echte bewijzen moeten komen om uw stelling hard te maken.
    Kees Braam
  • Lesley Alberts :
    Reactie weggehaald wegens sluikreclame. bij herhaling wordt u geblokkeerd.

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