Lees ook eens dit artikel: https://kanker-actueel.nl/chirurgie-pdt-foto-dynamische-therapie-met-bremachlorin-geeft-veel-betere-overall-overleving-op-5-jaar-dan-alleen-chirurgie-van-melanomen-vanuit-moedervlekken-ontstaan.html 

5 mei 2021: Bron: European Journal of Cancer Prevention: November 2017 - Volume 26 - Issue 6 - p 532-541

Huidkanker van het type melanoom, waarmee meer en meer mensen wereldwijd worden gediagnosteerd, is het resultaat van ingewikkelde interacties tussen individuele genetische factoren en omgevingsrisicofactoren waaronder vooral Ultraviolette straling - zonlicht. Ultraviolette straling vormt de belangrijkste omgevingsrisicofactor voor de ontwikkeling van huidkanker, waaronder dus het melanoom.

In onderstaande reviewstudie wordt aan de hand van de tot nu toe beschikbare literatuur een analyse gemaakt van met name de rol van de vitamine D-status in relatie tot een melanoom. Het is een puur wetenschappelijke analyse en niet echt voor leken, maar voor artsen en wetenschappers en ook voedingsdeskundigen is dit een hele interessante reviewstudie.

Blootstelling aan de zon en vroege zonnebrand tijdens de kindertijd zijn de belangrijkste oorzaken van het opkomen van huidmelanomen bij volwassenen, met een dubbel zo groot risico in vergelijking met een niet-blootgestelde populatie. Daarom wordt bescherming tegen ultraviolette straling al lang erkend als een belangrijke maatregel om een ​​dergelijke vorm van kanker te voorkomen.

Fig. 2

Fig. 2: 
Vitamin-D-related compounds at skin level. UV, ultraviolet.


Biologische en epidemiologische gegevens suggereren dat de vitamine D-status het risico op kanker zou kunnen beïnvloeden en een rol zou kunnen spelen bij kankerpreventie door antiproliferatieve effecten uit te oefenen. Zonnestraling is cruciaal voor de synthese van vitamine D bij mensen; Ongecontroleerde en intensieve blootstelling aan de zon is echter gevaarlijk voor de gezondheid van de huid en kan bijdragen aan de ontwikkeling van kwaadaardig huidmelanoom. Een optimale balans tussen zonwering en blootstelling wordt dus bepleit.

Aanvullend onderzoek is nodig om de preventieve rol van vitamine D bij de incidentie van melanomen of een positieve invloed op de uitkomst van de patiënt te bevestigen.

Fig. 3

Fig. 3: 
Systemic production of vitamin D compounds and biological effects. 1,25(OH)2D3, 1,25-dihydroxycholecalciferol; 25(OH)D3, 25-hydroxycholecalciferol.


In deze reviewstudie wordt aan de hand van de tot nu toe beschikbare literatuur een analyse gemaakt van met name de rol van de vitamine D status in relatie tot een melanoom.

Het is een puur wetenschappelijke analyse en niet echt voor leken, maar voor artsen en wetenschappers en ook voedingsdeskundigen is dit een hele interessante reviewstudie. Klik op de titel voor het volledige studierapport:

Vitamin D status and risk for malignant cutaneous melanoma: recent advances

Ombra, Maria N.a; Paliogiannis, Panagiotisb; Doneddu, Valentinab; Sini, Maria C.c; Colombino, Mariac; Rozzo, Carlac; Stanganelli, Ignaziod; Tanda, Francescob; Cossu, Antoniob; Palmieri, Giuseppec

Author Information
European Journal of Cancer Prevention: November 2017 - Volume 26 - Issue 6 - p 532-541
doi: 10.1097/CEJ.0000000000000334


Conclusion

In recent years, there has been growing interest in understanding the link between vitamin D status and melanoma as well as other cancers and chronic diseases. The relationship of serum levels and genetic factors of vitamin D with melanoma risk and melanoma mortality is actually not completely clear. There are few strong epidemiological studies to confirm the hypothesis that higher vitamin D levels might protect from melanoma, although a number of cohort studies have addressed a possible protective effect of vitamin D. In addition, there are insufficient indications to recommend vitamin D supplementation to decrease melanoma risk.

Certainly, vitamin D has clear antiproliferative activity on melanoma cell lines in vitro. There is evidence of reduced expression of the vitamin D receptor with progression from nevi through primary to metastatic melanoma. These observations suggest that if vitamin D is antiproliferative for melanoma cells in vivo, then those cells might be less likely to respond to the antiproliferative effects of vitamin D as progression occurs. Other results indicate that high levels of vitamin D are correlated with the development of less aggressive tumors. Some studies report that normal levels of vitamin D3 at the time of diagnosis are associated with a better prognosis in patients with melanoma. High circulating vitamin D concentration has been found to be associated with reduced melanoma progression and improved survival. Furthermore, reduced vitamin D serum levels have been reported in patients with stage IV melanoma compared with those with stage I.

An unresolved question remains as to which of the many described biological effects of vitamin D might have a protective effect for melanoma patients and what might be the optimal blood level to achieve those putative beneficial effects. The in-vitro antiproliferative effect of vitamin D added to melanoma cell cultures is convincing, and the Leeds Melanoma Cohort data suggest that primaries in individuals included in the study were thinner in patients with higher 25-hydroxyvitamin D2/D3 levels, which is consistent with an antiproliferative effect. Vitamin D, moreover, may exert pleomorphic effects including those on new blood vessel formation and immunity, and some of these effects might actually be deleterious for cancer patients. The reported effects of vitamin D on the immune system are extremely complex. If vitamin D supplementation suppresses adaptive immunity, then that would be a potentially harmful effect for melanoma patients. High doses of vitamin D should also be avoided. The evidence that vitamin D levels might influence melanoma risk remains uncertain; however, it should also be pointed out that studies of sufficient size to address this issue have not been carried out. In addition, there is evidence that patients with MM who strictly avoid sun exposure might benefit from 25-(OH)D supplements that are sufficient to maintain serum levels above 30 ng/ml. Given the interest in using vitamin D to reduce cancer risk, more research is warranted to establish its role in the control and progression of melanoma and whether vitamin D supplements can reduce risk and progression and improve outcomes.

Although the association between vitamin D and melanoma risk is still the object of considerable discussion, the potential effect of vitamin D on the risk of melanoma merits accurate consideration.

Acknowledgements

The authors are grateful to Maria Giglio and Francesco Rassu for their supporting assistance in this study.

Conflicts of interest

There are no conflicts of interest.

References

Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, Gallicchio L, et al. (2010). Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 19:2739–2745.
Bonilla C, Boxill LA, Donald SA, Williams T, Sylvester N, Parra EJ, et al. (2005). The 8818 G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. Hum Genet 116:402–406.
Casula M, Muggiano A, Cossu A, Budroni M, Caracò C, Ascierto PA, et al. (2009). Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy. BMC Cancer 9:352.
Colombino M, Lissia A, Franco R, Botti G, Ascierto PA, Manca A, et al. (2013). Unexpected distribution of cKIT and BRAF mutations among southern Italian patients with sinonasal melanoma. Dermatology 226:279–284.
Colombino M, Sini MC, Lissia A, De Giorgi V, Stanganelli I, Ayala F, et al. (2014). Discrepant alterations in main candidate genes among multiple primary melanomas. J Trans Med 12:117.
Cossu A, Casula M, Cesaraccio R, Lissia A, Colombino M, Sini MC, et al. (2016). Epidemiology and genetic susceptibility of malignant melanoma in North Sardinia, Italy. Eur J Cancer Preven [Epub ahead of print].
de Gruijter JM, Lao O, Vermeulen M, Xue Y, Woodwark C, Gillson CJ, et al. (2011). Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing. Investig Genet 2:24.
Deeb KK, Trump DL, Johnson CS (2007). Vitamin D signaling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 7:684–700.
Dooley CM, Schwarz H, Mueller KP, Mongera A, Konantz M, Neuhauss SC, et al. (2013). Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease. Pigment Cell Melanoma Res 26:205–217.
Evans SR, Nolla J, Hanfelt J, Shabahang M, Nauta RJ, Shchepotin IB (1998). Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer. Clin Cancer Res 4:1591–1595.
Fang S, Sui D, Wang Y, Liu H, Chiang YJ, Ross MI, et al. (2016). Association of vitamin D levels with outcome in patients with melanoma after adjustment for C-reactive protein. J Clin Oncol 34:1741–1747.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917.
Gambichler T, Scola N, Bechara FG (2012). Significantly decreased methylthioadenosine phosphorylase expression in malignant melanoma. Am J Dermatopathol 34:777–779.
Garbe C, Leiter U (2009). Melanoma epidemilogy and trends. Clin Dermatol 27:3–9.
Garland CF, Garland FC, Gorham ED (2003). Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates. Ann Epidemiol 13:395–404.
Graf J, Hodgson R, van Daal A (2005). Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation. Hum Mutat 25:278–284.
Grant WB (2002). An estimate of premature cancer mortality in the US due to inadequate doses of solar ultraviolet-B radiation. Cancer 94:1867–1875.
Guerrieri-Gonzaga A, Gandini S (2013). Vitamin D and overall mortality. Pigment Cell Melanoma Res 26:16–28.
Gupta R, Dixon KM, Deo SS, Holliday CJ, Slater M, Halliday GM, et al. (2007). Photoprotection by 1,25 dihydroxyvitamin D3 is associated with an increase in p53 and a decrease in nitric oxide products. J Invest Dermatol 127:707–715.
Haines ST, Park SK (2012). Vitamin D supplementation: what’s known, what to do, and what’s needed. Pharmacotherapy 32:354–382.
Holick MF (2003). Evolution and function of vitamin D. Recent Results Cancer Res 164:3–28.
Holick MF (2004). Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79:362–371.
Holick MFFavus MJ (2005). Vitamin D: photobiology, metabolism, mechanism of action and clinical application. Primer on the metabolic bone diseases and disorders of mineral metabolism, 5th ed. Washington, DC: American Society for Bone and Mineral Research. 129–136.
Holick MF (2007). Vitamin D deficiency. N Engl J Med 357:266–281.
Holick MF, Chen TC (2008). Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:S1080–S1086.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930.
Hou W, Wan X, Fan J (2015). Variants Fok1 and Bsm1 on VDR are associated with the melanoma risk: evidence from the published epidemiological studies. BMC Genet 16:14.
Lamason RL, Mohideen MA, Mest JR, Wong AC, Norton HL, Aros MC, et al. (2005). SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science 310:1782–1786.
Linos E, Swetter SM, Cockburn MG, Colditz GA, Clarke CA (2009). Increasing burden of melanoma in the United States. J Invest Dermatol 129:1666–1674.
López S, García O, Yurrebaso I, Flores C, Acosta-Herrera M, Chen H, et al. (2014). The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population. PLoS One 9:e104367.
Lucotte G, Mercier G, Diéterlen F, Yuasa I (2010). A decreasing gradient of 374F allele frequencies in the skin pigmentation gene SLC45A2, from the north of West Europe to North Africa. Biochem Genet 48:26–33.
Major JM, Kiruthu C, Weinstein SJ, Horst RL, Snyder K, Virtamo J (2012). Pre-diagnostic circulating vitamin D and risk of melanoma in men. PLoS One 7:e35112.
Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, et al. (2006). Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. Cancer Res 66:4574–4583.
Moan J, Dahlback ADubertret L, Santus R, Morliere P (1995). Predictions of health consequences of changing UV-fluence. Ozone, sun, cancer, 1st ed. Paris: Les Editions Inserm. 87–100.
Moan J, Dahlback A, Setlow RB (1990). Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiation. Photochem Photobiol 70:243–247.
Moan J, Porojnicu AC, Dahlback A (2008). Ultraviolet radiation and malignant melanoma. Adv Exp Med Biol 624:104–116.
Moan J, Grigalavicius M, Baturaite Z, Juzeniene A, Dahlback A (2013). North-South gradients of melanomas and non-melanomas: a role of vitamin D? Dermatoendocrinol 5:186–191.
Nan H, Kraft P, Hunter DJ, Han J (2009). Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Int J Cancer 125:909–917.
Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, et al. (2004). Comparative high resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet 13:1633–1639.
Newton JM, Cohen-Barak O, Hagiwara N, Gardner JM, Davisson MT, King RA, et al. (2001). Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4. Am J Hum Genet 69:981–988.
Newton-Bishop JA, Beswick S, Randerson-Moor J, Chang YM, Affleck P, Elliott F, et al. (2009). Serum 25-hydroxyvitamin D3 levels are associated with Breslow thickness at presentation and survival from melanoma. J Clin Oncol 27:5439–5444.
Norman AW, Bouillon R, Whiting SJ, Vieth R, Lips P (2007). 13th Workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 103:204–205.
Nürnberg B, Gräber S, Gärtner B, Geisel J, Pföhler C, Schadendorf D, et al. (2009). Reduced serum 25-hydroxyvitamin D levels in stage IV melanoma patients. Anticancer Res 29:3669–3674.
Pálmer HG, Larriba MJ, García JM, Ordóñez-Morán P, Peña C, Peiró S, et al. (2004). The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat Med 10:917–919.
Parkin DM (2011). The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer 105:S2–S5.
Pena-Chilet M, Ibarrola-Villava M, Martin-González M, Feito M, Gomez-Fernandez C, Planelles D, et al. (2013). rs12512631 on the group specific complement (Vitamin D-Binding Protein GC) implicated in melanoma susceptibility. PLoS One 8:e59607.
Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. (2013). Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality – a review of recent evidence. Autoimmun Rev 12:976–989.
Prosser DE, Jones G (2004). Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci 29:664–673.
Raimondi S, Pasquali E, Gnagnarella P, Serrano D, Disalvatore D, Johansson HA, et al. (2014). BsmI polymorphism of vitamin D receptor gene and cancer risk: a comprehensive meta-analysis. Mutat Res 769:17–34.
Rass K, Reichrath J (2008). UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer. Adv Exp Med Biol 624:162–178.
Reichrath J, Reichrath S (2012). Hope and challenge: the importance of ultraviolet (UV) radiation for cutaneous vitamin D synthesis and skin cancer. Scand J Clin Lab Invest 243:112–119.
Rigel DS (2010). Epidemiology of melanoma. Semin Cutan Med Surg 29:204–209.
Rochel N, Tocchini-Valentini G, Egea PF, Juntunen K, Garnier JM, Vihko P, et al. (2001). D. Functional and structural characterization of the insertion region in the ligand binding domain of the vitamin D nuclear receptor. Eur J Biochem 268:971–979.
Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. (2011). The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58.
Schwartz GG, Whitlatch LW, Chen TC, Lokeshwar BL, Holick MF (1998). Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev 7:391–395.
Shipman AR, Clark AB, Levell NJ (2011). Sunnier European countries have lower melanoma mortality. Clin Exp Dermatol 36:544–547.
Spina CS, Tangpricha V, Uskokovic M, Adorinic L, Maehr H, Holick MF (2006). Vitamin D and cancer. Anticancer Res 26:2515–2524.
Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Siegfried Z, et al. (2010). Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell 17:273–285.
Stumpf WE, Sar M, Reid FA, Tanaka Y, De Luca HF (1979). Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary and parathyroid. Science 206:1188–1190.
Tagliabue E, Raimondi S, Gandini S (2015). Meta-analysis of vitamin D-binding protein and cancer risk. Cancer Epidemiol Biomarkers Prev 24:1758–1765.
Tang JY, Fu T, Leblanc E, Manson JE, Feldman D, Linos E, et al. (2011). Calcium plus vitamin D supplementation and the risk of nonmelanoma and melanoma skin cancer: post hoc analyses of the women’s health initiative randomized controlled trial. J Clin Oncol 29:3078–3084.
Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004). Genetics and biology of vitamin D receptor polymorphisms. Gene 338:143–156.
Valverde P, Healy E, Jackson I, Rees JL, Thody AJ (1995). Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet 11:328–330.
Vinceti M, Malagoli C, Fiorentini C, Longo C, Crespi CM, Albertini G, et al. (2011). Inverse association between dietary vitamin D and risk of cutaneous melanoma in a northern Italy population. Nutr Cancer 63:506–513.
Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, et al. (2010). Common genetic determinants of vitamin D insufficiency. Lancet 376:180–188.
Weinstein SJ, Purdue MP, Smith-Warner SA, Mondul AM, Black A, Ahn J, et al. (2015). Serum 25-hydroxyvitamin D, vitamin D binding protein and risk of colorectal cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Int J Cancer 136:654–664.
Welsh J (2011). Vitamin D metabolism in mammary gland and breast cancer. Mol Cell Endocrinol 347:55–60.
Wu XC, Eide MJ, King J, Saraiya M, Huang Y, Wiggins C, et al. (2011). Racial and ethnic variations in incidence and survival of cutaneous melanoma in the United States, 1999–2006. J Am Acad Dermatol 65:S26–S37.
Yuasa I, Umetsu K, Harihara S, Kido A, Miyoshi A, Saitou N, et al. (2007). Distribution of two Asian-related coding SNPs in the MC1R and OCA2 genes. Biochem Genet 45:535–542.
Zhao XZ, Yang BH, Yu GH, Liu SZ, Yuan ZY (2014). Polymorphisms in the vitamin D receptor (VDR) genes and skin cancer risk in European population: a meta-analysis. Arch Dermatol Res 306:545–553.
Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S (2012). Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr 95:91–100.
Keywords:

calcitriol; cancer; melanoma; skin; sun exposure; vitamin D

Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.




Plaats een reactie ...

Reageer op "Vitamine D en de kans op het krijgen van huidkanker van het type melanoom. Een reviewstudie met uitleg over recente ontwikkelingen."


Gerelateerde artikelen
 

Gerelateerde artikelen

Vitamine D en de kans op het >> Studiepublicaties van voeding, >> Maretak injecties: Immuuntherapie >> Hyperthermie naast lokale >> Ozontherapie verlengt leven >> Voeding: Het Gersondieet bewijst >> Complementaire - aanvullende >>