22 juli 2012: Manju Ray heeft met collega's enkele jaren geleden de door haar zelf geleide studie bij kankerpatiënten van commentaar voorzien: Critical evaluation of toxic versus beneficial effects of methylglyoxal. Ik zal haar nog eens aanschrijven om te horen hoe het verder is gegaan met de andere patiënten uit haar studie.
2 oktober 2004:
Via dr. Manju Ray hebben we een tussentijds gedetaillleerd evaluatieverslag gekregen van 44 patiënten die vanaf 2001 tot augustus 2004 met methylglyoxal zijn behandeld. Met zeer opmerkelijke en positieve resultaten. Voor OPS-leden hebben we dit rapport op aanvraag via de redactie beschikbaar.
Table 1. Characteristics of the patients and outcome of the treatment (for further details see text)
Patient no. Age/Sex Diagnosis Time of detection Previous treatment received Commencement of the present treatment Present condition
1 32/M Adenocarcinoma of colon, metastasis to liver (both lobes) October 1999 Surgical resection of tumor, palliative treatment suggested January 2000 Excellent
2 73/F Acute myeloid leukemia Do Palliative treatment suggested due to very poor physical condition Do Do
3 46/M Non-Hodgkin's lymphoma, metastasis to lung and possibly to liver (relapsed case) December 1998 Chemotherapy twice without response February 2000 Do
4 72/F Mucin-secreting adenocarcinoma of colon, metastasis to liver, pericolic lymph nodes and gall bladder December 1999 A portion of the colon and gall bladder excised. Palliative treatment suggested Do Do
5 40/F Adenocarcinoma of ovary (relapsed after one year) with metastasis to omentum and peritoneal seeding December 1998 Ovaries removed followed by chemotherapy. After relapse chemotherapy was non-responsive March 2000 Do
6 40/F Serous cell adenocarcinoma of ovary (left), recurrence in right ovary during chemotherpy January 2000 Surgical removal of left ovary, chemotherapy non-responsive, surgical removal of right ovary Do Do
7 62/F Infiltrating duct carcinoma of breast with metastasis in axillary lymph node and bone (stage IIIB) Do Mastactomy done followed by radiation April 2000 Do
8 56/F Infiltrating duct carcinoma of breast with metastasis in lymph node and lung (stage IIIB-IV) Do Mastactomy done. Patient refused chemotherapy Do Do
9 36/M Papillary transitional cell carcinoma, 4th time recurrence - Surgery followed by chemotherapy twice. After 4th recurrence patient refused chemotherapy April 2000 Do
10 54/F Multiple myeloma (relapsed) osteoporosis December 1998 2nd time chemotherapy did not respond May 2000 Good
11 61/M Colorectal carcinoma December 1999 Surgical removal, external colestomy bag. Patient refused chemotherapy due to poor physical condition Do Excellent
12 35/M Ampullary carcinoma of liver, metastasis to pancreas with billiary obstruction May 2000 Endoscopic retrograde cholecysto pancreatography (ERCP) - steinting done, suggested palliative treatment Do Good
13 72/M Hepatocellular carcinoma March 2000 Palliative treatment suggested May 2000 Excellent
14 70/F Adenocarcinoma of colon, metastasis to liver and probably also in bone marrow May 2000 Do June 2000 Good
15 78/M Squamous cell carcinoma of tongue (recurrence in Nov. 1999) December 1998 Chemotherapy given on first detection, after recurrence only palliative treatment suggested due to poor physical condition Do Do
16 68/F Non-Hodgkin's lymphoma, metastasis to lung (small cell carcinoma), significant pleural effusion January 2000 Patient refused chemotherapy due to poor health Do Do
17 67/M Renal cell carcinoma (September 1998), metastasis to lung and bone (February 2000) 1998 Surgical removal of the kidney in 1998 and palliative treatment suggested after recurrence March 2000 Died, September 2000
18 75/M Bronchogenic carcinoma with massive pleural effusion - Palliative treatment suggested January 2000 Died, June 2000
19 55/F Infiltrating duct carcinoma with metastasis to breast, lung and liver (July 1999) ascites in peritonium July 1999 Sugery, radiotherapy and chemotherapy done with no response March 2000 Died May 2000
20 40/M Infiltrating squamous cell carcinoma of larynx, metastasis to lymph gland - Surgery performed before May 2000 Opted out, but patients condition was known to good
21 55/M Carcinoma of oesophagus - Only palliative treatment suggested April 2000 Opted out, died
22 65/F Metastatic adenocarcinoma of gall-bladder with involvement of liver and pancreas April 2000 Choledochoduodenostomy was done, palliative treatment suggested May 2000 Responded well, but opted out October 2000
23 78/M Squamous cell carcinoma of cheek (3rd time relapse) - - June 2000 Opted out September 2000
24 50/F Adenocarcinoma of pancreas - colangio-carcinoma, metastasis to liver, gall-bladder February 2000 Palliative treatment suggested March 2000 Response good, but opted out, died on May 2000
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