18 september 2017: Lees ook dit artikel: https://kanker-actueel.nl/NL/immuuntherapie-met-provenge-spirutacel-t-geeft-betere-resultaten-op-overall-overleving-bij-gevorderde-prostaatkanker-als-deze-gevolgd-wordt-door-dendritische-celtherapie.html

4 augustus 2011: Bron: Ther Adv Med Oncol. 2011 March; 3(2): 101–108. doi:  10.1177/1758834010397692

Provenge - Sipuleucel-T, blijkt in combinatie met dendritische celtherapie te zorgen voor een significante levensverlenging bij mannen met hormoon resistente prostaatkanker. Dit was al eerder bekend gemaakt , maar nu zijn nieuwe analyses van fase II en III studies openbaar gemaakt en is er een update gemaakt van de resultaten. Klik hier voor het volledige studierapport in therapeutic advances in Medical oncology. Hieronder het abstract van de meest recente studie. Daaronder een referentielijst van studies gedaan met Provenge - Sipuleucel-T, die een mooi overzicht geven van de ontwikkeling en ook wel de beperkingen van Provenge - Sipuleucel-T.

Sipuleucel-T in patients with metastatic castration-resistant prostate cancer: an insight for oncologists

Source: Ther Adv Med Oncol. 2011 March; 3(2): 101–108. doi:  10.1177/1758834010397692

Ther Adv Med Oncol. 2011 Mar;3(2):101-8.

Sipuleucel-T in patients with metastatic castration-resistant prostate cancer: an insight for oncologists.

Source

Director, Advanced Prostate Cancer Program, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue/R35, Cleveland, OH 44195, USA Garciaj4@ccf.org.

Abstract

Sipuleucel-T represents a novel immunotherapeutic compound designed to stimulate an immune response against castration-resistant prostate cancer (CRPC). Sipuleucel-T is an autologous active cellular immunotherapy product, which includes autologous dendritic cells pulsed ex vivo with PAP2024, a recombinant fusion protein made of prostatic acid phosphatase and granulocyte-macrophage colony-stimulating factor. Despite the lack of prostate-specific antigen and objective response, a recent phase III randomized trial demonstrated a significant improvement in overall survival in asymptomatic and minimally symptomatic CRPC patients. This review summarizes the clinical development of Sipuleucel-T in CRPC that led to the regulatory approval of this compound in the USA.

PMID:
21789160
[PubMed - in process]
PMCID: PMC3126040

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