Zie ook de artikelen op onze website via deze search met vitamine D in de titel

28 juni 2025: Bron: Nutrients 2025, 17(8), 1351

Vitamine D kan ontstaan van dikke darmkanker met zeker 25 procent verminderen als tijdig het tekort van vitamine D in het bloed wordt aangevuld met vitamine D rijke voeding, extra zonlicht en vitamine D suppletie. Vitamine D is zoals op wikipedia staat beschreven een groep van vet-oplosbare organische verbindingen die verantwoordelijk zijn voor de opname van calcium en fosfaat uit voeding. Vitamine D speelt ook een grote rol in ons immuunsysteem en zorgt met name voor tegengaan van ontstekingen in het lichaam. Orthokennis beschrijft hoe vitamine D en Calciferol = Vitamine D3 dat het eigen lichaam produceert onder invloed van zonlicht in dit artikel. 

Het abstract vertaalt in het Nederlands met hulp van google translate:

Samenvatting / abstract
  • Vitamine D speelt een cruciale rol in de regulering van het immuunsysteem, met immunomodulerende effecten die essentieel zijn voor de preventie van dikke darmkanker (CRC). Onderzoek in de afgelopen decennia heeft aangetoond dat dit steroïde hormoon veel meer beïnvloedt dan alleen de botgezondheid, en de immuunreacties aanzienlijk beïnvloedt.
  • Vitamine D versterkt de functies van immuunorganen zoals de milt en lymfeklieren, en stimuleert de activiteit van T-cellen, wat essentieel is voor de verdediging van het lichaam tegen tumoren.
  • Bovendien vermindert vitamine D ontstekingsreacties die nauw verband houden met de ontwikkeling van kanker, waardoor de ontsteking die bijdraagt ​​aan dikke darmkanker wordt verminderd. Het werkt via vitamine D-receptoren (VDR's) op immuuncellen en moduleert de immuunreacties.
  • Adequate vitamine D-spiegels beïnvloeden de genexpressie die verband houdt met ontsteking en celproliferatie, waardoor tumorontwikkeling wordt geremd.
  • Vitamine D activeert ook mechanismen die de overleving, proliferatie, migratie en metastasering van kankercellen onderdrukken.
  • Lage vitamine D-spiegels zijn in verband gebracht met een verhoogd risico op dikkedarmkanker, waarbij een tekort correleert met een hogere incidentie van de ziekte.
  • Leefstijlfactoren, zoals een dieet rijk aan rood vlees en calorieën maar arm aan vezels, fruit en groenten, evenals fysieke inactiviteit, dragen aanzienlijk bij aan het risico op dikkedarmkanker.
  • Onvoldoende inname van calcium en vitamine D wordt ook in verband gebracht met het optreden van de ziekte en slechtere klinische resultaten.
  • Het handhaven van optimale vitamine D-spiegels en een adequate voedingsinname is cruciaal om dikkedarmkanker te voorkomen en de prognose van de patiënt te verbeteren.
  • Deze review onderzoekt de rol van vitamine D in immuunregulatie en vat bevindingen samen uit gerandomiseerde klinische studies die de effecten van vitamine D-suppletie op de uitkomsten van dikkedarmkanker beoordelen.
In dit artikel: Can vitamin D help prevent colorectal cancer? The science is promising – but not straightforward wordt wel kritisch gekeken naar de conclusies uit de reviewstudie omdat verschillende gerandomiseerde studies geen meerwaarde van vitamine D zouden hebben aangetoond. Al zijn de auteurs van dit artikel ook wel positief over het aanvullen van vitamine D waarden tot een voldoende bloedwaarden niveau van vitamine D. en noemen ook verschillende studies die wel bewijzen dat vitamine D een grote meerwaarde kan hebben ook bij andere vormen van voorkomen of zxelfs behandelen van kanker. 

Het volledige verslag van de reviewstudie is gratis in te zien of te downloaden, klik daarvoor op de titel van de studie:

Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications

by   1,†,  1,2,†,  3,4,†,  2,3,  1,  5,  6,  1,  1,  1,  1 and  7,*
1
Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary
2
Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary
3
Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary
4
Department of Rheumatology and Clinical Immunology, Semmelweis University, 1023 Budapest, Hungary
5
Pulmonology Center of the Reformed Church in Hungary, 2045 Törökbálint, Hungary
6
HUN-REN Centre for Energy Research, 1121 Budapest, Hungary
7
Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2025, 17(8), 1351; https://doi.org/10.3390/nu17081351
Submission received: 4 March 2025 / Revised: 10 April 2025 / Accepted: 11 April 2025 / Published: 15 April 2025
(This article belongs to the Special Issue Dose–Response Relationships of Vitamin D Status and Vitamin D Intake with Health Outcomes—2nd Edition)
 
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Review Reports Versions Notes

Abstract

Vitamin D plays a crucial role in the regulation of the immune system, with immunomodulatory effects that are key in the prevention of colorectal cancer (CRC). Over the past decades, research has shown that this steroid hormone impacts much more than bone health, significantly influencing immune responses. Vitamin D enhances immune organ functions such as the spleen and lymph nodes, and boosts T-cell activity, which is essential in defending the body against tumors. Additionally, vitamin D mitigates inflammatory responses closely linked to cancer development, reducing the inflammation that contributes to CRC. It acts via vitamin D receptors (VDRs) expressed on immune cells, modulating immune responses. Adequate vitamin D levels influence gene expression related to inflammation and cell proliferation, inhibiting tumor development. Vitamin D also activates mechanisms that suppress cancer cell survival, proliferation, migration, and metastasis. Low levels of vitamin D have been associated with an increased risk of CRC, with deficiency correlating with higher disease incidence. Lifestyle factors, such as a diet high in red meat and calories but low in fiber, fruits, and vegetables, as well as physical inactivity, contribute significantly to CRC risk. Insufficient calcium and vitamin D intake are also linked to disease occurrence and poorer clinical outcomes. Maintaining optimal vitamin D levels and adequate dietary intake is crucial in preventing CRC and improving patient prognosis. This review explores the role of vitamin D in immune regulation and summarizes findings from randomized clinical trials assessing the effects of vitamin D supplementation on CRC outcomes.

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 in CRC management.

Funding

Open access funding was provided by Semmelweis University. This work was supported by TKP2021-NKTA-47, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, and financed under the TKP2021-NKTA funding scheme. Funding through the National Cardiovascular Laboratory Program (RRF-2.3.1–21-2022–00003) was also provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund. Additional support was provided by the European University for Well-Being (EUniWell) program (grant agreement number: 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019–1). AL was supported by the EKÖP-2024-9 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. The funding sources had no role in the study design, data collection, analysis, and interpretation, writing of the report, or the decision to submit the article for publication. The manuscript was improved using a GPT-based AI grammar check.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Conflicts of Interest

The authors declare no conflicts of interest.

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vitamine D, 25-hydroxycholecalciferol, preventie, dikkedarmkanker, review studie, immuunfunctie, inwendige ontstekingen


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