6 juli 2005: Bron: British Journal of Cancer (2005) 93, 15-22. doi:10.1038/sj.bjc.6602659 Published online 7 June 2005

Sojabonen, tofu en isaflavonen geven een significant preventief effect op lager risico van krijgen van borstkanker bij vrouwen in de leeftijdsfase voor de overgang. Het effect was niet-significant, maar wel ook nog wel een positief effect bij vrouwen na de overgang. Aldus een zo geheten case controle studie bij 167Japanese vrouwen met al aangetoonde borstkanker en 854 vrouwen met aangetoond geen borstkanker. Belangrijk lijkt deze studie ook voor vrouwen met borstkanker die na operatie of andere vorm van behandelen er alles aan willen doen om een recidief te voorkomen

British Journal of Cancer (2005) 93, 15-22.
doi:10.1038/sj.bjc.6602659 Published online 7 June 2005

Soybean products and reduction of breast cancer risk: a case-control study in Japan

K Hirose1, N Imaeda2, Y Tokudome3, C Goto3, K Wakai1, K Matsuo1, H Ito1, T Toyama4, H Iwata4, S Tokudome5 and K Tajima1
1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden Chikusa-ku, Nagoya 464-8681, Japan 2Nagoya Women's University, Mizuho-ku, Nagoya 467-8610, Japan
3Nagoya Bunri University, Inazawa 492-8520, Japan
4Department of Breast Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan
5Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Science, Mizuho-ku, Nagoya 467-8601, Japan

Correspondence to: Dr K Hirose, E-mail: khirose@aichi-cc.jp
Received 21 February 2005; revised 9 May 2005; accepted 9 May 2005; published online 7 June 2005

Components of the Japanese diet, which might contribute to the relatively low breast cancer incidence rates in Japan, have not been clarified in detail. Since soybean products are widely consumed in Japan, a case-control study taking account of the menopausal status was conducted using data from the hospital-based epidemiologic research program at Aichi Cancer Center (HERPACC). In total, 167 breast cancer cases were included and 854 women confirmed as free of cancer were recruited as the control group. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by multiple logistic regression analysis. There were reductions in risk of breast cancer associated with high intake of soybean products among premenopausal women. Compared with women in the lowest tertile, the adjusted ORs for top tertile intake of tofu (soybean curd) was 0.49 (95% CI, 0.25-0.95). A significant decrease in premenopausal breast cancer risk was also observed for increasing consumption of isoflavones (OR=0.44; 95% CI, 0.22-0.89 for highest vs lowest tertile; P for trend=0.02). The present study found a statistically inverse association between tofu or isoflavone intake and risk of breast cancer in Japanese premenopausal women, while no statistically significant association was evident with the risk among postmenopausal women.

Plaats een reactie ...

Reageer op "Sojabonen, tofu en isoflavonen geven een significant preventief effect op lager risico van krijgen van borstkanker bij vrouwen in de leeftijdsfase voor de overgang"


Gerelateerde artikelen