16 september 2007: Bron; 1: Qual Life Res. 2007 Apr;16(3):389-97. Epub 2006 Nov 17.

Wanneer primaire leverkanker wordt behandeld met TACE - Trans Arteriële Chemo Embolisatie en daarna gevolgd door RFA - Radio Frequency Ablation of LITT dan blijkt bij de groep die de combinatiebehandeling kreeg de kwaliteit van leven als aanzienlijk beter (significant) te worden ervaren. Dit blijkt uit een gerandomiserde studie onder 83 patienten.

Quality of life after radiofrequency ablation combined with transcatheter arterial chemoembolization for hepatocellular carcinoma: comparison with transcatheter arterial chemoembolization alone.Wang YB, Chen MH, Yan K, Yang W, Dai Y, Yin SS. Department of Ultrasound, Clinical Oncology Institute, Beijing University, No. 52 Fu-cheng Road, Hai-dian District, Beijing, 100036, China. wangyanbin689@163.com

OBJECTIVE: Comprehensive studies are scarce with regard to the quality of life (QOL) of hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE) and/or radiofrequency ablation (RFA) treatment. The purpose of this study was to examine the impact of TACE alone and that of the TACE followed by RFA (TACE-RFA) on QOL in HCC patients.

METHODS: QOL was measured using the Functional Assessment of Cancer Therapy-General (FACT-G) (Version 4.0) questionnaire, translated into Chinese, as a measure of QOL among Chinese HCC patients. Prospectively, 83 patients in both TACE group (n = 40) and TACE-RFA group (n = 43) completed the questionnaire at baseline and 3 months after treatment, respectively.

RESULTS: The TACE-RFA group resulted in a significantly higher total QOL score, socio-family well-being score, and functional well-being score than that of TACE group, 3 months after respective treatment. Liver function, tumor recurrence and complication, age, income were the most important factors affecting the QOL of HCC patients after treatment. The logistic regression analyses showed that Child-Pugh Class and tumor recurrence after treatment were independent predictors of post-treatment QOL scores of HCC patients.

CONCLUSIONS: The overall QOL of HCC patients in TACE-RFA group was maintained at a relatively higher level than that of TACE group. TACE followed by RFA appeared to be more favorable than TACE alone with respect to QOL. PMID: 17111232 [PubMed - indexed for MEDLINE]

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