Mocht u kanker-actueel de moeite waard vinden en ons willen ondersteunen om kanker-actueel online te houden dan kunt u ons machtigen voor een periodieke donatie via donaties: https://kanker-actueel.nl/NL/donaties.html of doneer al of niet anoniem op - rekeningnummer NL79 RABO 0372931138 t.n.v. Stichting Gezondheid Actueel in Amersfoort. Onze IBANcode is NL79 RABO 0372 9311 38   
Elk bedrag is welkom. En we zijn een ANBI instelling dus uw donatie of gift is in principe aftrekbaar voor de belasting.

En als donateur kunt u ook korting krijgen bij verschillende bedrijven: 

https://kanker-actueel.nl/NL/voordelen-van-ops-lidmaatschap-op-een-rijtje-gezet-inclusief-hoe-het-kookboek-en-de-recepten-op-basis-van-uitgangspunten-van-houtsmullerdieet-te-downloaden-enof-in-te-zien.html

20 augustus 2017: lees ook dit artikel: 

https://kanker-actueel.nl/NL/arsenic-trioxide-intraveneus-in-combinatie-met-tace-geeft-veel-betere-resultaten-voor-in-longen-uitgezaaide-gevorderde-primaire-leverkanker-dan-tace-alleen.html

27 mei 2016: lees ook dit artikel over hetzelfde onderwerp: 

https://kanker-actueel.nl/NL/arsenicum-trioxide-ato-geeft-significant-betere-resultaten-naast-tace-bij-patienten-met-primaire-leverkanker-met-longuitzaaiingen.html

27 mei 2016: Bron: CANCER: Version of Record online: 29 MAY 2015 DOI: 10.1002/cncr.29456

Ook deze studie (aanvullend op onderstaande studiepublicatie uit maart 2015) geeft heel goede resultaten van arsenicum trioxide gebruikt in loco regionale behandeling met leverspoelingen (o.a. TACE) van vergevorderde primaire leverkanker. Meer dan de helft van de patienten uit de groep van arsenicum triode overleefde de 25 maanden studiefollow-up: 15 patienten van de 61 overleden in de arsenicum trioxidegroep versus 34 patienten uit 64 patienten uit de controlegroep. Een onvoorstelbaar groot verschil voor een groep patienten die inoperabele leverkanker hadden en zwaar waren voorbehandeld.

Het volledige studierapport: Randomized clinical control study of locoregional therapy combined with arsenic trioxide for the treatment of hepatocellular carcinoma. is gratis in te zien met duidlejik grafieken enz. Onder dit artikel staat het abstract ervan.

Hier een van de grafieken uit bovenstaande studie. daaronder beschrijving van andere studie

Arsenicum trioxide studie bij TACE en leverkanker


23 november 2015: lees ook dit artikel: 

https://kanker-actueel.nl/NL/tace-plus-gemoduleerd-virus-adenovirus-h101-verbetert-significant-ziektevrije-tijd-en-overall-overleving-plus-16-procent-in-vergelijking-met-alleen-tace-bij-inoperabele-primaire-leverkanker-stadium-4.html

19 maart 2015: Bron: J Cancer Res Clin Oncol. 2014 Dec 14. [Epub ahead of print]

Wanneer TACE - Trans Arteriële Chemo Embolisatie wordt uitgevoerd met Arseentrioxide bij primaire leverkanker met uitzaaiingen in de longen en de patiënten aanvullend daarna regelmatig intraveneuze injecties krijgen met ATO - arseentrioxide dan stijgt de mediane overleving van 2,9 maanden naar 7,3 maanden en blijkt de ziektecontrole maar liefst met 65% te verbeteren van 72,8% versus 7,2% in vergelijking met alleen TACE plus arseentrioxide. Een spectaculaire verbetering dus. Je zou je ook nog af kunnen vragen wat er gaat gebeuren als ATO intraveneus wordt vervangen / uitgebreid door ATRA - All-trans-Retionic-Acid. Of simpeler in het Nederlands een vorm van vitamine A plus kleine dosis arsenicum. Zie o.a. deze studie: 

https://kanker-actueel.nl/NL/acute-promyelocitische-leukemie-apl-volledig-te-genezen-met-niet-toxische-aanpak-van-all-trans-retinoic-acid-atra-en-arseentrioxide-ato-en-zonder-chemo.html 

Met, ik citeer wat Francesco Lo-Coco, MD, professor in de hematologie aan de universiteit van Tor Vergata in Rome, Italië zei. Heel opmerkelijk aan deze studie is dat volgens dr. Lo-Coco  het bewijs geleverd wordt dat het mogelijk is kwaadaardige kankercellen (met ATRA)  te transformeren in normale cellen zonder deze te doden met chemotherapie.  "Kanker is blijkbaar geen onomkeerbare toestand".

Blijkbaar werkt ATRA als een anti-PD middel. Is heel wat goedkoper dan bv. nivolumab, wat overigens ook spectaculaire resultaten laat zien bij verschillende vormen van kanker, waaronder bij melanomen: 

https://kanker-actueel.nl/NL/immuuntherapeutische-behandelingen-met-ipilimumab-en-nivolumab-gelijktijdig-gegeven-geeft-spectaculaire-resultaten-80-procent-tumorreductie-bij-melanoompatienten-met-uitgezaaide-vergevorderde-vooraf-intensief-behandelde-ziekte.html

en bij darmkanker loopt al een fase III studie in verschillende Europese landen waaronder ook Nederland: https://www.clinicaltrialsregister.eu/ctr-search/trial/2012-000095-42/NL.

Arseentrioxide

De nieuwste studie publicatie geeft deze resultaten:

RESULTATEN:

Tussen April 2013 en June 2014, kregen 139 patienten de TACE - behandeling. 70 van hun namen deel aan de studiegroep TACE met ATO plus daarna intraveneus ATO en 69 van hun vormden de controlegroep: TACE + ATO maar zonder intraveneuze ATO. Alle patienten konden de volledige behandeling volgens het studieprotocol volgen, niemand haakte af tijdens de studieduur.

De mediane overall overleving was 7.3 maanden (95 % CI = 6.8-7.8) in de studiegroep van TACE + ATO + ATO intraveneus en 2.9 maanden (95 % CI = 2.6-3.1) in de controlegroep met alleen TACE + ATO.  Dit was statistisch significant (P < 0.001). De mediane progressie vrije tijd (TTP) was 2.7 maanden (95 % CI = 1.9-3.3) voor de studiegroep van TACE + ATO + ATO intraveneus en 1.2 (95 % CI = 1.0-1.9) maanden in de controle groep (P = 0.023). Ziektecontrole DCR - Disease Control) bleek in de studiegroep van TACE + ATO + ATO intraveneus 72.85 % versus 7,24% in de controlegroep. En de onafhankelijke vastgestelde respons (ORR - objective response rate) was 7.14 %, tegenover in de controlegroep 0.00 %. DCR - ziektecontrole en ORR - onafhankelijke respons gaven dus een significant verschil te zien tussen de twee groepen (P < 0.001 en P = 0.024, respectievelijk).

Het volledige studierapport: Arsenic trioxide transarterial chemoembolization with and without additional intravenous administration of arsenic trioxide in unresectable hepatocellular carcinoma with lung metastasis: a single-blind, randomized trial. kunt u tegen betaling inzien.

Hier het abstract van de studie:

Arsenic trioxide transarterial chemoembolization and intravenous administration were safe and effective in unresectable hepatocellular carcinoma with lung metastasis.

Date: 14 Dec 2014

Arsenic trioxide transarterial chemoembolization with and without additional intravenous administration of arsenic trioxide in unresectable hepatocellular carcinoma with lung metastasis: a single-blind, randomized trial

Abstract

Aim

To evaluate the efficacy and safety of arsenic trioxide transarterial chemoembolization and intravenous administration in unresectable hepatocellular carcinoma with lung metastasis.

Methods

A single-blind, two-parallel group, randomized trial was conducted at three medical centers (Guangzhou, China), including patients with both biopsy-confirmed hepatocellular carcinoma and lung metastasis. The experimental group received arsenic trioxide transarterial chemoembolization and intravenous administration of arsenic trioxide, while the control group only received arsenic trioxide transarterial chemoembolization. We compared overall survival (OS), time to progression (TTP), disease control rate (DCR), and objective response rate (ORR) between the groups.

Results

Between April 2013 and June 2014, 139 patients received the allocated intervention, 70 of whom were in the experimental group and 69 of whom were in the control group. No patient was lost to follow-up. The median OS was 7.3 (95 % CI = 6.8–7.8) months in the experimental group and 2.9 (95 % CI = 2.6–3.1) months in the control group (P < 0.001). The median TTP was 2.7 (95 % CI = 1.9–3.3) months in the experimental group and 1.2 (95 % CI = 1.0–1.9) months in the control group (P = 0.023). In the experimental group, the DCR was 72.85 % and the ORR was 7.14 %, while in the control group, the DCR was 7.24 % and the ORR was 0.00 %. DCR and ORR differed significantly between the two groups (P < 0.001 and P = 0.024, respectively).

Conclusions

Arsenic trioxide transarterial chemoembolization and intravenous administration were safe and effective in unresectable hepatocellular carcinoma with lung metastasis.

References:

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Locoregional therapy combined with arsenic trioxide prevents extrahepatic metastasis and prolongs the survival time for primary HCC patients

Cancer. 2015 Sep 1;121(17):2917-25. doi: 10.1002/cncr.29456. Epub 2015 May 29.

Randomized clinical control study of locoregional therapy combined with arsenic trioxide for the treatment of hepatocellular carcinoma.

Abstract

BACKGROUND:

The objective of this study was to determine the efficacy and safety of locoregional therapy (LRT) combined with arsenic trioxide (As2 O3 ) treatment in primary hepatocellular carcinoma (HCC) patients.

METHODS:

One hundred twenty-five primary HCC patients were recruited for a randomized controlled study. Patients were randomly divided into group A (n = 61) and group B (n = 64). All patients received transarterial chemoembolization. Group A patients were given As2 O3 at 10 mg/d for 4 courses (21 days per course) with a 2-week interval between courses. Survival times, therapeutic responses, extrahepatic metastases, and adverse events were recorded.

RESULTS:

A better therapeutic response was found in group A patients, as shown by higher objective response rate (ORR) and clinical benefit rate (CBR) values in group A versus group B (ORR, 81.96% [95% confidence interval (CI), 72.32%-91.62%] vs 59.37% [95% CI, 47.34%-71.41%], χ(2)  = 7.650, P < .05; CBR, 95.08% [95% CI, 89.66%-100.00%] vs 81.25% [95% CI, 71.69%-90.81%], χ(2)  = 5.659, P < .05). There were fewer patients with extrahepatic metastases in group A versus group B (group A, 6 cases or 9.84% [95% CI, 2.36%-17.31%]; group B, 12 cases or 18.75% [95% CI, 9.19%-28.31%]). The survival rate for group A patients was significantly higher than that for group B patients (P < .05). No significant differences were found between the 2 groups in terms of hematology or digestive system, liver, or kidney dysfunction except for facial and limb edema.

CONCLUSIONS:

LRT combined with As2 O3 treatment prevents extrahepatic metastasis and prolongs the survival time for primary HCC patients.

© 2015 American Cancer Society.

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