1 mei 2010:

Vitamine D ingenomen door voeding of in de vorm van een tabletje (voedingsupplement) lijkt het risico op borstkanker te verkleinen. Aldus de conclusies uit twee onafhankelijk van elkaar uitgevoerde bevolkingsstudies in Japan en Amerika. Wat interessant is dat er in Japan ook gekeken is naar het effect van vitamine D. bij vrouwen voor de overgang en bij vrouwen na de overgang en naar HER-2Neu status en progesteron receptoren. In beide studies is ook gekeken naar calcium inname in samenhang met vitamine D maar daarvoor werd geen overtuigend bewijs gevonden. Wel bleek ook alleen calcium inname het risico op borstkanker te verlagen.

Hier de twee abstracten:

Cancer Sci. 2010 Jan 12. [Epub ahead of print]

Association between vitamin D and calcium intake and breast cancer risk according to menopausal status and receptor status in Japan.

Kawase T, Matsuo K, Suzuki T, Hirose K, Hosono S, Watanabe M, Inagaki M, Iwata H, Tanaka H, Tajima K.

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.

Abstract

Although several studies have investigated the possible association between elevated vitamin D and calcium intake and low breast cancer risk, findings have been inconsistent. We conducted a case-control study to clarify the association between vitamin D and calcium intake and breast cancer risk among pre- and post- menopausal women in Japan. We also investigated whether these effects were modified by tumor receptor status, specifically estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor-2 (HER2) status. We examined 1803 breast cancer patients and 3606 age- and menopausal status-matched noncancer controls. Among cases, 713 were assessed for ER, PR, and HER2 status. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using conditional or unconditional logistic models adjusted for potential confounders. A significant inverse association was observed between vitamin D and calcium intake and breast cancer risk among all subjects, with top quartile ORs of 0.76 (95% CI, 0.63-0.90; trend P = 0.001) and 0.83 (95% CI, 0.69-0.99; trend P = 0.038), respectively. In analyses stratified by menopausal status, a significant association between risk and vitamin D was observed only among premenopausal women (trend P < 0.001), whereas that between risk and calcium intake was seen only among postmenopausal women (trend P = 0.022). Heterogeneity by menopausal status for these associations was statistically significant. This association was modified by tumor receptor status. These findings suggest that the protective effects of vitamin D and calcium intake against breast cancer risk may differ by menopausal status and receptor status. (Cancer Sci 2010).

PMID: 20151981 [PubMed - as supplied by publisher]

 

Am J Clin Nutr. 2010 Apr 14. [Epub ahead of print]

Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women.

Anderson LN, Cotterchio M, Vieth R, Knight JA.

From Population StudiesSurveillance Cancer Care Ontario Toronto Canada.

Abstract

BACKGROUND: Some evidence suggests that vitamin D may reduce breast cancer risk. Despite the biological interaction between vitamin D and calcium, few studies have evaluated their joint effects on breast cancer risk.

OBJECTIVE: The objective was to evaluate the associations and potential interaction between vitamin D and calcium (from food and supplements) and breast cancer risk in a population-based case-control study.

DESIGN: Breast cancer cases aged 25-74 y (diagnosed 2002-2003) were identified through the Ontario Cancer Registry. Controls were identified by using random digit dialing; 3101 cases and 3471 controls completed epidemiologic and food-frequency questionnaires. Adjusted odds ratios (ORs) and 95% CIs were estimated by using multivariate logistic regression.

RESULTS: Vitamin D and calcium intakes from food only and total combined intakes (food and supplements) were not associated with breast cancer risk, although the mean intake of vitamin D was low. Vitamin D supplement intake >10 mug/d (400 IU/d) compared with no intake was associated with a reduced risk of breast cancer (adjusted OR: 0.76; 95% CI: 0.59, 0.98). No categories of calcium supplement intake were significantly associated with reduced breast cancer risk, but a significant inverse trend was observed (P = 0.04). There were no significant interactions involving vitamin D, calcium, or menopausal status.

CONCLUSIONS: No associations were found between overall vitamin D or calcium intake and breast cancer risk. Vitamin D from supplements was independently associated with reduced breast cancer risk. Further research is needed to investigate the effects of higher doses of vitamin D and calcium supplements.

PMID: 20392891 [PubMed - as supplied by publisher]

 


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