7 mei 2023: Zie ook dit artikel: https://kanker-actueel.nl/ai-algoritmen-kunstmatige-intelligentie-ontdekken-kankerknobbeltjes-op-de-longen-die-radiologen-nog-niet-kunnen-waarnemen-en-kan-belangrijk-zijn-om-patienten-eerder-en-succesvol-te-behandelen.html

21 oktober 2022: lees ook dit artikel: https://kanker-actueel.nl/NL/e-nose-techniek-ruikt-verschil-tussen-darmkanker-en-darmpoliepen-en-zou-darmkanker-vroegtijdig-op-kunnen-sporen-aldus-studie-uit-het-vumc.html

21 oktober 2022: Lees ook dit artikel (abstract onderaan artikel): 

Sniffer dogs can identify lung cancer patients from breath and urine samples

Results of breath tests – detection rates

The dog correctly predicted cancer in 32 of 41 breath samples, corresponding to a detection rate of 78% (95% CI [62.4, 89.4%]). This did not differ significantly from the reference value of 78% (p = 0.5851). Results are depicted in Table 2.


21 oktober 2022: Bron: Tubantia en MST Twente

Sharina Kort, werkzaam als longarts in opleiding in het Medisch Spectrum Twente Enschede deed onderzoek naar de mogelijkheden van een ademtest via de aeoNose, een draagbare ademanalysator, ook wel de elektronische neus genoemd, om longkanker in een vroegtijdig stadium op te sporen. Sharina Kort presenteerde haar studie in Barcelona afgelopen week. 

Op de website van het MST staat een uitgebreide uitleg in het Engels wat zij gevonden heeft in haar onderzoek:  

DETECTION OF LUNG CANCER IN EXHALED BREATH WITH ELECTRONIC NOSE TECHNOLOGY

THE PHD DEFENCE OF SHARINA KORT WILL TAKE PLACE (PARTLY) ONLINE AND CAN BE FOLLOWED BY A LIVE STREAM.
LIVE STREAM

Sharina Kort is a PhD student in the research group Cognition, Data and Education. Supervisor is prof.dr. J.A.M. van der Palen from the Faculty of Behavioural, Management and Social Sciences and co-supervisors are dr. M.G.J. Brusse-Keizer from MST (Medisch Spectrum Twente) and dr. H. Schouwink from the Faculty of Behavioural Management and Social Sciences.

Een paar korte quotes uit dit artikel:

In Hoofdstuk 4 hebben we een verkennende multicenter studie uitgevoerd om de Aeonose te trainen om niet-kleincellige longkankerpatiënten te onderscheiden van proefpersonen zonder longkanker op basis van uitgeademde adem. Op basis van 290 proefpersonen (144 NSCLC-patiënten, 146 controles) was het voorspellingsmodel in staat om beide groepen te onderscheiden met een sensitiviteit van 94%, een specificiteit van 33%, een negatief voorspellende waarde (NPV) van 86% en een AUC van 0,76 (95% betrouwbaarheidsinterval (BI): 0,71-0,82).

........
Aangezien de trainingsstudies, met en zonder klinische variabelen, veelbelovende resultaten lieten zien van de Aeonose om longkanker te diagnosticeren, hebben we een groot, multicenter, multinationaal validatieonderzoek uitgevoerd met meerdere Aeonose-apparaten om de reproduceerbaarheid en robuustheid van de verkregen resultaten te beoordelen. De resultaten van deze validatiestudie worden gepresenteerd in hoofdstuk 6. 

........we rekruteerden nieuwe proefpersonen en voerden een split-sample-ontwerp uit dat de ontwikkeling en daaropvolgende validatie van een nieuw voorspellingsmodel mogelijk maakte. De trainingsset bestond uit 376 proefpersonen (160 longkankerpatiënten, 216 klinisch relevante controles) en de validatieset bestond uit 199 proefpersonen (79 longkankerpatiënten, 120 controles). ............Dit voorspellingsmodel toonde een sensitiviteit van 88%, een specificiteit van 48%, een PPV van 52%, een NPV van 87%, met een AUC van 0,79 (95% BI: 0,72-0,85) in de validatieset.>>>>>>>lees het hele artikel met de uitleg verder

De Tubantia schreef er ook een artikel over:

Enschedese onderzoekt elektrische neus: 'Longkanker kan je ruiken'

Sharina Kort uit Enschede deed onderzoek naar de mogelijkheden van de elektronische neus, een nieuwe methode om longkanker in een vroegtijdig stadium op te sporen. 'Het klinkt ongelofelijk, maar kanker kun je ruiken.'

Dit artikel is afkomstig uit Tubantia. 

Sinds 2015 al is ze met haar onderzoek bezig. Sharina Kort, momenteel werkzaam als longarts in opleiding in het Enschedese ziekenhuis MST, investeerde zes jaar van haar leven in de mogelijkheden van ademanalyse. Met haar promotie onlangs aan de Universiteit Twente rondde ze een eerste grote fase af, specifiek gericht op de opsporing van longkanker. Uitgangspunt was en is het gebruik van de elektronische neus, een relatief nieuwe techniek om de ziekte in een vroegtijdig stadium op te sporen.>>>>>>>lees verder

We conclude that olfactory detection of lung cancer by specifically trained dogs is highly suggestive to be a simple and non-invasive tool to detect lung cancer.


Abstract

Background

Lung cancer is the most common oncological cause of death in the Western world. Early diagnosis is critical for successful treatment. However, no effective screening methods exist. A promising approach could be the use of volatile organic compounds as diagnostic biomarkers. To date there are several studies, in which dogs were trained to discriminate cancer samples from controls. In this study we evaluated the abilities of specifically trained dogs to distinguish samples derived from lung cancer patients of various tumor stages from matched healthy controls.

Methods

This single center, double-blind clinical trial was approved by the local ethics committee, project no FF20/2016. The dog was conditioned with urine and breath samples of 36 cancer patients and 150 controls; afterwards, further 246 patients were included: 41 lung cancer patients comprising all stages and 205 healthy controls. From each patient two breath and urine samples were collected and shock frozen. Only samples from new subjects were presented to the dog during study phase randomized, double-blinded. This resulted in a specific conditioned reaction pointing to the cancer sample.

Results

Using a combination of urine and breath samples, the dog correctly predicted 40 out of 41 cancer samples, corresponding to an overall detection rate of cancer samples of 97.6% (95% CI [87.1, 99.9%]). Using urine samples only the dog achieved a detection rate of 87.8% (95% CI [73.8, 95.9%]). With breath samples, the dog correctly identified cancer in 32 of 41 samples, resulting in a detection rate of 78% (95% CI [62.4, 89.4%]).

Conclusions

It is known from current literature that breath and urine samples carry VOCs pointing to cancer growth. We conclude that olfactory detection of lung cancer by specifically trained dogs is highly suggestive to be a simple and non-invasive tool to detect lung cancer. To translate this approach into practice further target compounds need to be identified.

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Acknowledgements

We would like to thank Thomas Riemann-Seibert, Chairman of the board of the Heidrun-Seibert Stiftung, Dieburg, Germany, who proposed the idea behind the presented study to CS. We would also like to thank the Heidrun-Seibert Stiftung for financial support.

Funding

This study was supported by grants from the Heidrun-Seibert Stiftung, Dieburg, Germany. The funding organization was not involved in the design and implementation of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.

Author information

Author notes

  1. Charlotte Feil and Frank Staib contributed equally to this work.

Authors and Affiliations

  1. 2nd Department of Internal Medicine, Municipal Hospital Darmstadt, Grafenstraße 9, 64283, Darmstadt, Germany

    Charlotte Feil, Frank Staib, Thorsten Stein & Carl C. Schimanski

  2. Toxicology and Chemotherapy Unit, German Cancer Research Center, Heidelberg, Germany

    Martin R. Berger

  3. Institute for Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg-University Mainz, Mainz, Germany

    Irene Schmidtmann

  4. Pulmonologist’s Office Darmstadt, Darmstadt, Germany

    Andreas Forster

Contributions

All authors made contributions to the study concept and design; CF, TS, and AF acquired study participants, samples or data; CF, FS, MRB, TS, IS, CS interpreted data; IS provided support for statistical analysis; CF wrote the manuscript; FS, MRB, TS and CS proofread and revised the manuscript. All authors read and approved the final manuscript. CF and FS contributed equally (shared first authorship).

Corresponding author

Correspondence to Carl C. Schimanski.

Ethics declarations

Ethics approval and consent to participate

The study and all experimental protocols, which also include the involved sniffer dog, were approved by the local ethics committee (at the national physician chamber Hessen in Frankfurt, Germany), project no FF20/2016 and have been performed in accordance with the Declaration of Helsinki. All methods were carried out in accordance with their relevant guidelines and regulations. Written informed consent was obtained from all study participants. Furthermore, informed consent was obtained from the owner of the involved dog.

The animal study was carried out in compliance with the ARRIVE guidelines.

Consent for publication

Not applicable.

Competing interests

The authors have declared that they have no conflicts of interests.

Additional information

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Ademtest, eletronische neus, aeoNose, preventie, niet-kleincellige longkanker, Sharina Kort, het Medisch Spectrum Twente (MST), ruiken van kanker


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