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The benefits of immunotherapy combinations

By giving treatments in tandem, researchers hope to reach a wider range of patients.

In Nature is een artikel gepubliceerd dat combinatiebehandelingen van immuuntherapeutische medicijnen bespreekt, al of niet met traditionele medicijnen. Hier enkele grafieken uit dit artikel dat volledig gratis is te lezen.

By giving immunotherapies to people with cancer, doctors hope to spark a self-sustaining attack against cancer cells by immune cells known as T cells that produces long-term clinical benefits, or even a cure. Around 2,000 immunotherapeutic agents are in development, reports the Cancer Research Institute in New York City. But some people will respond better to the drugs than do others, and many don’t respond to them at all. Moreover, tumours can become resistant to such agents over time.

These limitations have pushed immunotherapy researchers towards the use of several drugs in combination. “There’s lots of interest in these trials, and people are tripping over each other trying to test as many combinations as possible,” says Leena Ghandi, a thoracic medical oncologist at the Laura and Isaac Perlmutter Cancer Center of the New York University Langone Medical Center. Other data gathered by the Cancer Research Institute show that 403 such trials opened worldwide in the first six months of 2017 (see ‘In combination: more trials, better targeted’). More than 1,100 are in progress.

Source: Jun Tang and Vanessa Lucey, Anna-Maria Kellen Clinical Accelerator program, Cancer Research Institute

By combining immunotherapies, or pairing them with other types of cancer treatment such as chemotherapy or radiation, researchers hope to enhance and broaden the benefits. But combination treatments for cancer that include immunotherapies face specific challenges, both clinical and economic.>>>>>>>Reed more

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