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1 maart 2018: zie ook dit artikel: 

https://kanker-actueel.nl/champignons-bewerkt-met-speciale-belichting-hebben-daarmee-veel-extra-vitamine-d-en-kunnen-vitamine-d-supplementen-vervangen.html

30 maart 2015: lees ook deze reviewstudie van PSK - polysaccharide, extracten van medicinale paddenstoelen bij longkanker

polysaccharide-k-psk-verbetert-immuunfunctie-vermindert-bijwerkingen-van-chemo-en-verlengt-levensduur-van-longkankerpatienten-blijkt-uit-grote-overzichtstudie.html

In The health benefits of medicinal mushrooms from Mark Stengler een Engelstalig boek over medicinale paddenstoelen wordt beschreven hoe de paddestoelen moeten worden klaargemaakt en gegeten. Raadpleeg wel altijd een deskundig arts hiervoor.

10 juni 2011: Bron: Queensland university of technology

PSP voorkomt prostaatkanker en voorkomt een recidief blijkt uit een gerandomiseerde dierstudie met muizen doordat het stamcellen met kanker elimineert en voorkomt dat deze uitgroeien tot tumoren. Onderaan staat ook een zelfde soort studie maar dan bij leukemie cellen. Echt interessante studies. 

Dat het stofje polysaccharopeptide (PSP) uit bepaalde paddestoelen een therapeutisch effect heeft op vele vormen van kanker is al veel langer bekend. (zie gerelateerde artikelen) Nu hebben Australische wetenschappers aangetoond hoe dit werkt. Zij gebruikten daarvoor een groep transgene muizen die allemaal prostaatkanker stamcellen hadden en in potentie dus prostaatkanker hadden en er zich verder prostaatkanker tumoren zouden moeten ontwikkelen. De groep muizen werd gerandomiseerd ingedeeld in twee groepen. De ene groep kreeg gewone voeding, de andere groep kreeg aan het voedsel PSP toegevoegd. Van de groep muizen die PSP kregen ontwikkelde geen enkele muis prostaatkanker. De stamcellen met prostaatkanker werden allemaal geelimineerd voordat ze konden uitgroeien tot een tumorcel. De onderzoekers spreken van een doorbraak in de preventie en voorkoming van prostaatkanker. Er zijn nameljik al veel studies bij mensen gedaan en deze dierstudie was enkel opgezet om aan te tonen hoe dit nu precies werkt.

Hier een persbericht hoe de universiteit van Quensland in Australie dit bekendmaakte:   

Mushroom compound suppresses prostate tumours

A mushroom used in Asia for its medicinal benefits has been found to be 100 per cent effective in suppressing prostate tumour development in mice during early trials, new Queensland University of Technology (QUT) research shows.

The compound, polysaccharopeptide (PSP), which is extracted from the 'turkey tail' mushroom, was found to target prostate cancer stem cells and suppress tumour formation in mice, an article written by senior research fellow Dr Patrick Ling in the international scientific journal PLoS ONE said.

Dr Ling, from the Australian Prostate Cancer Research Centre-Queensland and Institute for Biomedical Health & Innovation (IHBI) at QUT, said the results could be an important step towards fighting a disease that kills 3000 Australian men a year.

"The findings are quite significant," Dr Ling said.

"What we wanted to demonstrate was whether that compound could stop the development of prostate tumours in the first place.

"In the past, other inhibitors tested in research trials have been shown to be up to 70 per cent effective, but we're seeing 100 per cent of this tumour prevented from developing with PSP.

"Importantly, we did not see any side effects from the treatment."

Dr Ling said conventional therapies were only effective in targeting certain cancer cells, not cancer stem cells, which initiated cancer and caused the disease to progress.

During the research trial, which was done in collaboration with The University of Hong Kong and Provital Pty Ltd, transgenic mice that developed prostate tumours were fed PSP for 20 weeks.

Dr Ling said no tumours were found in any of the mice fed PSP, whereas mice not given the treatment developed prostate tumours. He said the research suggested that PSP treatment could completely inhibit prostate tumour formation.

"Our findings support that PSP may be a potent preventative agent against prostate cancer, possibly through targeting of the prostate cancer stem cell population," he said.

He said PSP had been previously shown to possess anti-cancer properties, and 'turkey tail' mushrooms (known as Coriolus versicolor or Yun-zhi) had been widely used in Asia for medicinal benefits.

However, Dr Ling said it was the first time it had been demonstrated that PSP had anti-cancer stem cell effects.

Although 'turkey tail' mushrooms had valuable health properties, Dr Ling said it would not be possible to get the same benefit his research showed from simply eating them.

A fundraiser has been organised in September to support further tests for the therapeutic potential of PSP against prostate tumours either alone or in combination with other anti-cancer compounds.

Media contact: Stephanie Harrington, media officer, 3138 1150, stephanie.harrington@qut.edu.au

 

Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity™ (PSP)

Bron: BMC. Klik voor het volledige studierapport hier.

Tze-chen Hsieh,1 Peili Wu,#1 Spencer Park,#1 and Joseph M Wu1
1Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
Corresponding author.
#Contributed equally.
Tze-chen Hsieh: Tze-Chen_Hsieh@nymc.edu ; Peili Wu: Peili_Wu@nymc.edu ; Spencer Park: sp362@cornell.edu ; Joseph M Wu: Joseph_Wu@nymc.edu
Received April 13, 2006; Accepted September 11, 2006.
Background
I'm-Yunity™ (PSP) is a mushroom extract derived from deep-layer cultivated mycelia of the patented Cov-1 strain of Coriolus versicolor (CV), which contains as its main bioactive ingredient a family of polysaccharo-peptide with heterogeneous charge properties and molecular sizes. I'm-Yunity™ (PSP) is used as a dietary supplement by cancer patients and by individuals diagnosed with various chronic diseases. Laboratory studies have shown that I'm-Yunity™ (PSP) enhances immune functions and also modulates cellular responses to external challenges. Recently, I'm-Yunity™ (PSP) was also reported to exert potent anti-tumorigenic effects, evident by suppression of cell proliferation and induction of apoptosis in malignant cells. We investigate the mechanisms by which I'm-Yunity™ (PSP) elicits these effects.
Methods
Human leukemia HL-60 and U-937 cells were incubated with increasing doses of aqueous extracts of I'm-Yunity™ (PSP). Control and treated cells were harvested at various times and analyzed for changes in: (1) cell proliferation and viability, (2) cell cycle phase transition, (3) induction of apoptosis, (4) expression of cell cycle, apoptogenic/anti-apoptotic, and extracellular regulatory proteins.
Results
Aqueous extracts of I'm-Yunity™ (PSP) inhibited cell proliferation and induced apoptosis in HL-60 and U-937 cells, accompanied by a cell type-dependent disruption of the G1/S and G2/M phases of cell cycle progression. A more pronounced growth suppression was observed in treated HL-60 cells, which was correlated with time- and dose-dependent down regulation of the retinoblastoma protein Rb, diminution in the expression of anti-apoptotic proteins bcl-2 and survivin, increase in apoptogenic proteins bax and cytochrome c, and cleavage of poly(ADP-ribose) polymerase (PARP) from its native 112-kDa form to the 89-kDa truncated product. Moreover, I'm-Yunity™ (PSP)-treated HL-60 cells also showed a substantial decrease in p65 and to a lesser degree p50 forms of transcription factor NF-κB, which was accompanied by a reduction in the expression of cyclooxygenase 2 (COX2). I'm-Yunity™ (PSP) also elicited an increase in STAT1 (signal transducer and activator of transcription) and correspondingly, decrease in the expression of activated form of ERK (extracellular signal-regulated kinase).
Conclusion
Aqueous extracts of I'm-Yunity™ (PSP) induces cell cycle arrest and alterations in the expression of apoptogenic/anti-apoptotic and extracellular signaling regulatory proteins in human leukemia cells, the net result being suppression of proliferation and increase in apoptosis. These findings may contribute to the reported clinical and overall health effects of I'm-Yunity™ (PSP).

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