9 juni 2012: Bron: Chin Med J (Engl). 2012 Jan;125(2):178-81.

Wanneer oudere darmkankerpatiënten voor en na de operatie extra visolie krijgen via infuus dan blijken deze patiëntren sneller te herstellen en minder kans te hebben op complicaties zoals infecties. Dit blijkt uit een gerandomiseerde studie met totaal 57 patiënten. Als u hier klikt kunt u het volledige studierapport gratis inzien. Hier het abstract van deze studie.

Fish oil 0.2 g/kg per day administrated to elderly patients after colorectal surgery was safe and may shorten the length of hospital stay and improve clinical outcomes.

Impact of fish oil enriched total parenteral nutrition on elderly patients after colorectal cancer surgery
ZHU Ming-wei, TANG Da-nian, HOU Jing, WEI Jun-min, HUA Bin, SUN Jian-hua , CUI Hong-yuan
ZHU Ming-wei Department of General Surgery, Beijing Hospital, Beijing 100730, China; TANG Da-nian Department of General Surgery, Beijing Hospital, Beijing 100730, China; HOU Jing Department of General Surgery, Beijing Hospital, Beijing 100730, China; WEI Jun-min Department of General Surgery, Beijing Hospital, Beijing 100730, China; HUA Bin Department of General Surgery, Beijing Hospital, Beijing 100730, China; SUN Jian-hua Department of General Surgery, Beijing Hospital, Beijing 100730, China; CUI Hong-yuan Department of General Surgery, Beijing Hospital, Beijing 100730, China

Correspondence to: TANG Da-nian  Department of General Surgery, Beijing Hospital, Beijing 100730, China  (Email:tangdn@hotmail.com )
Abstract:
Background  Polyunsaturated omega-3 fatty acids may beneficially influence healing processes and patient outcomes. The aim of this research was to study the clinical efficacy of fish oil enriched total parenteral nutrition in elderly patients after colorectal cancer surgery.
Methods  Fifty-seven elderly patients with colorectal cancer were enrolled in this prospective, randomized, double-blind, controlled clinical trial. All patients received isocaloric and isonitrogenous total parenteral nutrition by continuous infusion (20–24 hours per day) for seven days after surgery. The control group (n=28) received 1.2 g/kg soybean oil per day, whereas the treatment group (n=29) received 0.2 g/kg fish oil and 1.0 g/kg soybean oil per day. Blood samples were taken pre-operatively, and at days one and eight after the operation. The plasma levels of CD4, CD8, CD4/CD8, interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) were measured. Clinical outcomes were then analysed.
Results  Patient characteristics were comparable between the two groups. At day eight post-surgery, IL-6, TNF-α and CD8 titres were lower in the treatment group when compared to the control group; these results reached statistical significance. In the treatment group, there were fewer infectious complications and incidences of systemic inflammatory response syndrome (SIRS), and shorter lengths of hospital stay were observed. The total cost of medical care was comparable for the two groups. No serious adverse events occurred in either group.
Conclusions  Fish oil 0.2 g/kg per day administrated to elderly patients after colorectal surgery was safe and may shorten the length of hospital stay and improve clinical outcomes.

REFERENCES
 
1.          Fürst P, Kuhn NS. Fish oil emulsions: what benefit can they bring? Clin Nutr 2000; 19: 7-14.
2.          Adolph M, Heller AR, Koch T, Koletzko B, Kreymann KG, Krohn K, et al. Lipid emulsions–Guidelines on Parenteral Nutrition, Chapter 6. Ger Med Sci 2009; 7: Doc22.
3.          Calder PC. Polyunsaturated fatty acids, inflammation, and immunity. Lipids 2001; 36: 1007-1024.
4.          Köller M, Senkal M, Kemen M, Konig W, Zumtobel V, Muhr G. Impact of omega-3 fatty acid enriched TPN on leukotriene synthesis by leukocytes after major surgery. Clin Nutr 2003; 22: 59-64.
5.          Jiang ZM, Wilmore DW, Wang XR, Wei JM, Zhang ZT, Gu ZY, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg 2010; 97; 804-809.
6.          Wichmann MW, Thul P, Czarnetzki HD, Morlion BJ, Kemen M, Jauch KW. Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion(Lipoplus MLF541): data from a prospective, randomizes, controlled multicenter clinical trials. Crit Care Med 2007; 35: 700-706.
7.          Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definition of nosocomial surgical site infection, 1992: a modification of CDC definition of surgical wound infections. Am J Infect Control 1992; 20: 271-274.
8.          American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864-874.
9.          Kielar ML, Jeyarajah DR, Zhou XJ, Lu CY. Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthase. J Am Soc Nephrol 2003; 14: 389-396.
10.       Weiss G, Meyer F, Matthies B, Pross M, Koenig W, Lippert H. Immunonutrition by perioperative administration of n-3 fatty acids. Br J Nutr 2002; 87(Suppl 1): S89-S94.
11.       Tsekos E, Reuter C, Stehle P, Boeden G. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery. Clin Nutr 2004; 23: 325-330.
12.       Schauder P, Rohn U, Schafer G, Korff G, Schenk HD. Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period. Br J Nutr 2002; 87(Suppl 1): s103-s110.
13.       Heller AR, Fischer S, Rossel T, Geiger S, Siegert G, Ragaller M, et al. Impact of n-3 fatty acid supplemented parenteral nutrition on haemostasis patterns after major abdominal surgery. Br J Nutr 2002; 87(Suppl 1): 95-101.

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