Visolie bevordert herstel van darmkankerpatienten na operatie en vermindert kans op complicaties zoals infecties

9 juni 2012: Bron: Chin Med J (Engl). 2012 Jan;125(2):178-81.

Wanneer oudere darmkankerpatiënten voor en na de operatie extra visolie krijgen via infuus dan blijken deze patiëntren sneller te herstellen en minder kans te hebben op complicaties zoals infecties. Dit blijkt uit een gerandomiseerde studie met totaal 57 patiënten. Als u hier klikt kunt u het volledige studierapport gratis inzien. Hier het abstract van deze studie.

Fish oil 0.2 g/kg per day administrated to elderly patients after colorectal surgery was safe and may shorten the length of hospital stay and improve clinical outcomes.

Impact of fish oil enriched total parenteral nutrition on elderly patients after colorectal cancer surgery

ZHU Ming-wei, TANG Da-nian, HOU Jing, WEI Jun-min, HUA Bin, SUN Jian-hua , CUI Hong-yuan

ZHU Ming-wei Department of General Surgery, Beijing Hospital, Beijing 100730, China; TANG Da-nian Department of General Surgery, Beijing Hospital, Beijing 100730, China; HOU Jing Department of General Surgery, Beijing Hospital, Beijing 100730, China; WEI Jun-min Department of General Surgery, Beijing Hospital, Beijing 100730, China; HUA Bin Department of General Surgery, Beijing Hospital, Beijing 100730, China; SUN Jian-hua Department of General Surgery, Beijing Hospital, Beijing 100730, China; CUI Hong-yuan Department of General Surgery, Beijing Hospital, Beijing 100730, China

Correspondence to: TANG Da-nian Department of General Surgery, Beijing Hospital, Beijing 100730, China (Email:tangdn@hotmail.com )

Abstract:

Background Polyunsaturated omega-3 fatty acids may beneficially influence healing processes and patient outcomes. The aim of this research was to study the clinical efficacy of fish oil enriched total parenteral nutrition in elderly patients after colorectal cancer surgery.

Methods Fifty-seven elderly patients with colorectal cancer were enrolled in this prospective, randomized, double-blind, controlled clinical trial. All patients received isocaloric and isonitrogenous total parenteral nutrition by continuous infusion (20–24 hours per day) for seven days after surgery. The control group (n=28) received 1.2 g/kg soybean oil per day, whereas the treatment group (n=29) received 0.2 g/kgfish oil and 1.0 g/kg soybean oil per day. Blood samples were taken pre-operatively, and at days one and eight after the operation. The plasma levels of CD4, CD8, CD4/CD8, interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) were measured. Clinical outcomes were then analysed.

Results Patient characteristics were comparable between the two groups. At day eight post-surgery, IL-6, TNF-α and CD8 titres were lower in the treatment group when compared to the control group; these results reached statistical significance. In the treatment group, there were fewer infectious complications and incidences of systemic inflammatory response syndrome (SIRS), and shorter lengths of hospital stay were observed. The total cost of medical care was comparable for the two groups. No serious adverse events occurred in either group.

Conclusions Fish oil 0.2 g/kg per day administrated to elderly patients after colorectal surgery was safe and may shorten the length of hospital stay and improve clinical outcomes.

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infecties, operatie, darmkanker, visolie