Zie ook in gerelateerde artikelen.

11 november 2019: met dank aan R. Hamers die ons op deze studie wees.

Aanvullend op onderstaande informatie lees ook dit studierapport: Omega-3 polyunsaturated fatty acid oral supplements for improving peripheral nerve health: a systematic review and meta-analysis

een reviewstudie over de waarde van visolie in het verminderen van neuropathie door chemo. Abstract onderaan artikel

 

9 maart 2016: Bron: Nutr Cancer. 2016 Jan;68(1):70-6. doi: 10.1080/01635581.2016.1115097. Epub 2015 Dec 23

Wanneer darmkankerpatiënten naast hun chemo 9 weken lang visolie krijgen dan ontstaat mediaan pas na 20 maanden (593 dagen) progressie van de ziekte terwijl patiënten die geen visolie kregen maar een placebo mediaan al na 11 maanden (330 dagen) progressie toonden van hun ziekte. Dit is bijna een verdubbeling van de ziekteprogressievrije tijd. (visoliegroep 593 dagen (±211.5) vs. placebogroep 330 dagen (± 135.1); P = 0.04]. Dit is echt spectaculair te noemen bij deze patientengroep. Ruim anderhalf jaar progressievrije ziekte komt bijna niet voor bij standaardbehandelingen voor uitgezaaide darmkanker.

Ook de CEA waarden daalden sneller en werden sneller en bleven langer lager in de visoliegroep dan in de placebogroep.

Ook een reviewstudie laat zien dat visolie zelfs een anti-PD effect kan hebben wanneer gebruikt naast gercihte behandelingen en / of naast chemo en/of bestraling bij vele verschillende vormen van kanker. Verderop in dit artikel de twee abstracten.

visolie studie

Deze studie kreeg ik toegestuurd door arts-bioloog drs. Engelbert Valstar met deze begeleidende tekst gericht aan prof. Voest, zie ook gerelateerde artikelen:

Wederom bewijs dat chemo (met o.a. oxaliplatin) juist gebaat is bij visolie ; dat Voest iets anders vindt in een muizenonderzoek (het andere is qua statistiek alleen goed voor de prullenbak) komt omdat hij de cisplatin oraal geeft ; visolie is ontstekingsremmend en ik denk dat daardoor de opname van cisplatin via de darm geremd wordt ; dit was bij voorbaat te verwachten (hij onderzoekt dus een artefact) ; waarom dan cisplatin bij muizen oraal geven, terwijl je weet dat dit bij de mens niet gebeurt en alle onderzoeken waarin dit niet gedaan is (nu in totaal 4 bij de mens en 3 bij proefdieren het tegenovergestelde) namelijk een gunstige interactie wordt gevonden.

Het is jammer dat het volledige studierapport: Fish oil supplementation during chemotherapy increases posterior time to tumor progression in colorectal cancer niet gratis is te verkrijgen, of u moet er voor betalen.

Een andere studierapport is echter deze reviewstudie: Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy die bewijst dat visolie bij vele vormen van kanker en naast chemo en/of gerichte behandelingen voor goede resultaten zorgt. Zie ook de referentielijst van deze reviewstudie onderaan dit artikel

Hier de twee abstracten van de studies:

Supplementation with 2 g/day of fish oil for the first 9 wk of chemotherapy may contribute to delay in tumor progression in colorectal patients, possibly by enhancing the antineoplastic action of the chemotherapeutic drug.

Nutr Cancer. 2016 Jan;68(1):70-6. doi: 10.1080/01635581.2016.1115097. Epub 2015 Dec 23.

Fish oil supplementation during chemotherapy increases posterior time to tumor progression in colorectal cancer.

Abstract

The authors evaluated clinical outcomes during and after chemotherapy in colorectal cancer patients supplemented with fish oil during the first 9 wk of treatment. Thirty individuals never submitted to chemotherapy were randomized into supplemented group (SG), which received 2 g/day of fish oil (0.6 g/day of EPA and DHA) for 9 wk or control group (CG), which received neither fish oil nor placebo. Outcomes assessed were number of chemotherapy cycles administered; days undergoing chemotherapy; number of delays and interruptions in the administration of chemotherapy; number of hospitalizations during chemotherapy; tumor progression; values of carcinoembryonic antigen (CEA); days until events (death and progression); and 3 yr survival. Time to tumor progression was significantly longer in SG [S593 days (±211.5)] vs. CG [330 days (± 135.1); P = 0.04], other outcomes did not differ between groups. Subjects with advanced cancer who received fish oil presented longer time to tumor progression and lower CEA values after chemotherapy; however these differences were not statistically significant. Supplementation with 2 g/day of fish oil for the first 9 wk of chemotherapy may contribute to delay in tumor progression in colorectal patients, possibly by enhancing the antineoplastic action of the chemotherapeutic drug.

PMID:
26700096
[PubMed - in process]

This analysis can allow a better comprehension of the potential cytotoxic therapeutic role of n-3 PUFAs against cancer, providing specific information and support to design future pre-clinical and clinical studies for a better use of n-3 PUFAs in cancer therapy, mainly combinational therapy.

J Clin Med. 2016 Feb; 5(2): 15.
Published online 2016 Jan 26. doi:  10.3390/jcm5020015
PMCID: PMC4773771

Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy

Lindsay Brown, Academic Editor, Bernhard Rauch, Academic Editor, and Hemant Poudyal, Academic Editor

Abstract

Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development of drug resistance by tumor cells and toxicity towards normal cells. n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can exert anti-neoplastic activity by inducing apoptotic cell death in human cancer cells either alone or in combination with conventional therapies. Indeed, n-3 PUFAs potentially increase the sensitivity of tumor cells to conventional therapies, possibly improving their efficacy especially against cancers resistant to treatment. Moreover, in contrast to traditional therapies, n-3 PUFAs appear to cause selective cytotoxicity towards cancer cells with little or no toxicity on normal cells. This review focuses on studies investigating the cytotoxic activity of n-3 PUFAs against cancer cells via apoptosis, analyzing the molecular mechanisms underlying this effective and selective activity. Here, we highlight the multiple molecules potentially targeted by n-3 PUFAs to trigger cancer cell apoptosis. This analysis can allow a better comprehension of the potential cytotoxic therapeutic role of n-3 PUFAs against cancer, providing specific information and support to design future pre-clinical and clinical studies for a better use of n-3 PUFAs in cancer therapy, mainly combinational therapy.

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Pooled data showed a reduced incidence of peripheral neuropathy and a preservation of sensory nerve action potential amplitudes with omega-3 supplementation compared with placebo

Omega-3 polyunsaturated fatty acid oral supplements for improving peripheral nerve health: a systematic review and meta-analysis

Nutrition Reviews, nuz054, https://doi.org/10.1093/nutrit/nuz054
Published:
 
17 September 2019

Abstract

Context

Peripheral nerve damage can occur in a variety of systemic conditions and can have a profound impact on functional and psychological health. Currently, therapeutic interventions for peripheral nerve damage are limited.

Objective

The aim of this systematic review, conducted in accordance with the Cochrane Collaboration’s handbook and reported according to the PRISMA checklist, was to evaluate the efficacy and safety of omega-3 oral supplements for improving peripheral nerve structure and function.

Data Sources

PubMed, Embase, and Cochrane databases, along with clinical trial registries, were searched from inception to February 2019. Evidence was identified, critically appraised, and synthesized, and the certainty of evidence was appraised using the Grading of Recommendations Assessment, Development and Evaluation approach.

Study Selection

Randomized controlled trials assessing the effects of omega-3 oral supplementation on outcomes of peripheral nerve structure, peripheral nerve function, or both were eligible for inclusion. Titles and abstracts of identified articles were independently assessed for potential eligibility by 2 review authors. For studies judged as eligible or potentially eligible, full text articles were retrieved and independently assessed by 2 review authors to determine eligibility; disagreements were resolved by consensus.

Data Extraction

Fifteen trials were included. Two clinically similar studies that investigated the effect of omega-3 supplementation in individuals receiving chemotherapy were meta-analyzed. Pooled data showed a reduced incidence of peripheral neuropathy (RR = 0.58; 95%CI, 0.43–0.77) and a preservation of sensory nerve action potential amplitudes with omega-3 supplementation compared with placebo (MD = 4.19 µV; 95%CI; 2.19–6.19).

Conclusion

This review finds, with low certainty, that omega-3 supplementation attenuates sensory loss and reduces the incidence of neuropathy secondary to oxaliplatin and paclitaxel treatment relative to placebo. There is currently limited evidence to ascertain whether omega-3 supplementation is beneficial in other systemic conditions characterized by peripheral nerve damage.

Systematic Review Registration

PROSPERO registration number CRD 42018086297


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