4 februari 2025, Bron: Nature Aging
Wanneer 70-plussers regelmatig Omega-3 vetzuren innemen via bv paar keer per week vette vis eten en extra supplementen dan verbetert binnen drie jaar hun biologische leeftijd met gemiddeld 2 tot bijna vier maanden in vergelijking met mensen die weinig tot geen Omega-3 vetzuren gebruiken. Wanneer ze de inname van Omega-3 vetzuren combineren met vitamine D en regelmatig bewegen en sporten dan is de verbetering nog wat beter. Dat blijkt uit de langjarige doorlopende Europese DO-Health studie uit de deelstudie bij totaal 777 deelnemers van de Zwitserse DO-HEALTH Bio-Age studie.
In de Volkskrant zegt onderzoeker voeding en veroudering Pol Grootswagers (Wageningen Universiteit) wanneer hem deze resultaten worden voorgelegd: ‘Dit is een van de eerste klinische onderzoeken die kijkt naar een causaal effect van een voedselinterventie op die biologische leeftijd’, ‘En dat lijkt best goed te werken. Mooi dat je met voeding die klok langzamer kan laten lopen.’
De onderzoekers van de DO-HEALTH Bio-Age studie analyseerden vier verschillende DNA methylatie metingen die gerelateerd zijn aan biologische veroudering, te weten PhenoAge, GrimAge, GrimAge2 en DunedinPACE. Uiteindelijk gaven drie van de vier op 3 jaars meting een duidelijk verschil te zien in biologisch ouder worden van 2,9 tot 3,8 maanden in vergelijking met de mensen die weinig of geen Omega-3 vetzuren gebruikten in hun voedingspatroon.
In de Volkskrant zegt onderzoeksleider Bischoff: "Zie de uitkomsten vooral als ‘bemoedigend’ en ‘steun voor het idee dat gerichte voedingsstrategieën duidelijk effect op de veroudering kunnen hebben". "Vooral bij mensen die weinig Omega-3 vetzuren binnenkrijgen via hun voeding, kan het supplement veel uitmaken, blijkt uit de cijfers. ‘Dat versterkt de zaak voor een gepersonaliseerde aanpak."
Het volledige studierapport is gratis in te zien. Klik op de titel van het abstract zoals dat is gepubliceerd in Nature Aging:
- Letter
- Open access
- Published:
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Nature Aging (2025)
Abstract
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per day) and/or omega-3 (1 g per day) and/or a home exercise program on four next-generation DNA methylation (DNAm) measures of biological aging (PhenoAge, GrimAge, GrimAge2 and DunedinPACE) over 3 years. Omega-3 alone slowed the DNAm clocks PhenoAge, GrimAge2 and DunedinPACE, and all three treatments had additive benefits on PhenoAge. Overall, from baseline to year 3, standardized effects ranged from 0.16 to 0.32 units (2.9–3.8 months). In summary, our trial indicates a small protective effect of omega-3 treatment on slowing biological aging over 3 years across several clocks, with an additive protective effect of omega-3, vitamin D and exercise based on PhenoAge.
Reporting summary
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
Data availability
Data from DO-HEALTH, used in the context of this project, as well as codebooks and analytic codes, will initially be reserved for the primary researchers of the Center of Aging and Mobility Research Group to fully exploit the datasets. Subsequently, the data will be made available to external researchers according to a controlled access system. However, all data supporting the findings of this study are available from the corresponding author upon request.
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Acknowledgements
H.A.B.-F. acknowledges support from the Swiss National Science Foundation for the extraction and analysis of the DNAm assays of samples collected at baseline and 36 months from the Swiss subset of participants (grant no. 204452), as well as support from the Stiftung für Naturwissenschaftliche und Technische Forschung for the salary of a researcher. The DO-HEALTH study was funded by the Seventh Research Framework Program of the European Commission (grant agreement no. 278588, H.A.B.-F), and within this framework, also by the University of Zurich (Chair for Geriatric Medicine and Aging Research), DNP (H.A.B.-F), Roche (H.A.B.-F), NESTEC (H.A.B.-F), Pfizer (H.A.B.-F) and Streuli (H.A.B.-F). The funding organizations had no role in the design, data collection, management, analysis, interpretation of the study, writing of the manuscript or decision to submit the manuscript for publication.
Author information
Authors and Affiliations
Contributions
H.A.B.-F. has full access to all study data and takes responsibility for the integrity of the data and the accuracy of the data analysis. H.A.B.-F., B.V., R.R., W.W., B.D.-H., R.T., H.B.S., R.W.K. and E.J.O. contributed to the study design. H.A.B.-F., S. Gängler, B.V., R.R., W.W., B.D.-H., R.T., H.B.S., R.W.K., A.E. and E.J.O. contributed to data collection and/or verification. S. Gängler analyzed the data, under the supervision of H.A.B.-F. and S.H. H.A.B.-F., S. Gängler, D.W.B. and S.H. contributed to data interpretation. H.A.B.-F., in collaboration with S.H., wrote the first version of the paper. H.A.B.-F., S. Gängler, M.W., D.W.B., J.R., R.W.K., H.B.S., R.T., B.D.-H., R.R., B.V., L.R., S. Guyonnet, A.E., E.J.O., W.W. and S.H. revised the paper for important intellectual content. H.A.B.-F., S. Gängler, M.W., D.W.B., J.R., R.W.K., H.B.S., R.T., B.D.-H., R.R., B.V., L.R., S. Guyonnet, A.E., E.J.O., W.W. and S.H. had final responsibility for the decision to submit the manuscript for publication.
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