11 november 2019: Bron: The Oncologist First Published Online October 14, 2019 doi: 10.1634/theoncologist.2019-0489

Wanneer vrouwen met operabele borstkanker (stadium I tot III) na hun chemokuren perifere neuropathie ontwikkelen en 8 weken lang een acupunctuur behandeling krijgen dan vermindert dat de kans op verergering van de perifere neuropathie. (aan handen, vingers, voeten, tenen enz.) en verminderen juist de klachten en pijn. Zowel als de acupunctuur gegeven wordt direct na de chemokuren, als na 8 weken beste zorg alsnog een 8 wekenlange acupunctuur. 

Kernpunt van de gerandomiseerde studie bij totaal 40 borstkankerpatienten (20 vs 20):

Patiënten met door chemotherapie geïnduceerde perifere neuropathie (CIPN) na behandeling voor borstkanker werden gerandomiseerd naar acupunctuur of een wachtlijstcontrolegroep. Aanzienlijke verbeteringen in neuropathiesymptomen werden waargenomen na een acupunctuurregime van 8 weken vergeleken met de controlegroep.

Het studierapport: Acupuncture for Chemotherapy‐Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial is in PDF formaat gratis in te zien

Hier het abstract van de studie:

Acupuncture for Chemotherapy‐Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial

  1. Jennifer A. Ligibela

+Author Affiliations

  1. a Department of Medical Oncology, Dana‐Farber Cancer Institute, Boston, Massachusetts, USA
  2. b Division of Biostatistics, Department of Data Sciences, Dana‐Farber Cancer Institute, Boston, Massachusetts, USA
  3. c Department of Medical Statistics and Informatics, School of Medicine at the Catholic University of Daegu, Daegu, Republic of Korea
  1. *Correspondence: Weidong Lu, Ph.D., M.P.H., M.B., Leonard P. Zakim Center for Integrative Therapies and Healthy Living, Department of Medical Oncology, Dana‐Farber Cancer Institute, 450 Brookline Ave., Boston, Massachusetts 02215, USA. Telephone: 617‐632‐4350; e‐mail: weidong_lu@dfci.harvard.edu
  • Received June 27, 2019.
  • Accepted August 23, 2019.
  • Published online before print October 14, 2019.
  • Disclosures of potential conflicts of interest may be found at the end of this article.



Chemotherapy‐induced peripheral neuropathy (CIPN) is one of the most debilitating long‐term side effects in breast cancer survivors. We conducted a randomized controlled pilot trial to assess the feasibility, safety, and effects of an acupuncture intervention on CIPN in this population.

Patients and Methods.

Women with stage I–III breast cancer with grade 1 or higher CIPN after taxane‐containing adjuvant chemotherapy were randomized 1:1 to an immediate acupuncture (IA) arm or to a waitlist control group (CG). Participants in the IA arm received 18 sessions of acupuncture over 8 weeks, then received no additional acupuncture. Patients in the CG arm received usual care over 8 weeks, followed by nine sessions of acupuncture over 8 weeks. Measures including Patient Neurotoxicity Questionnaire (PNQ), Functional Assessment of Cancer Therapy—Neurotoxicity subscale (FACT‐NTX), and Brief Pain Inventory—short form (BPI‐SF) were collected at baseline and at 4, 8, and 16 weeks after enrollment.


Forty women (median age, 54) were enrolled (20 to IA and 20 to CG), with median time between completion of chemotherapy and enrollment of 14 months (range 1–92). At 8 weeks, participants in the IA arm experienced significant improvements in PNQ sensory score (−1.0 ± 0.9 vs. −0.3 ± 0.6; p = .01), FACT‐NTX summary score (8.7 ± 8.9 vs. 1.2 ± 5.4; p = .002), and BPI‐SF pain severity score (−1.1 ± 1.7 vs. 0.3 ± 1.5; p = .03), compared with those in the CG arm. No serious side effects were observed.


Women with CIPN after adjuvant taxane therapy for breast cancer experienced significant improvements in neuropathic symptoms from an 8‐week acupuncture treatment regimen. Additional larger studies are needed to confirm these findings.

Implications for Practice.

Chemotherapy‐induced peripheral neuropathy (CIPN) is a toxicity that often persists for months to years after the completion of adjuvant chemotherapy for early breast cancer. In a randomized pilot trial of 40 breast cancer survivors with CIPN, an 8‐week acupuncture intervention (vs. usual care) led to a statistically and clinically significant improvement in subjective sensory symptoms including neuropathic pain and paresthesia. Given the lack of effective therapies and established safety profile of acupuncture, clinicians may consider acupuncture as a treatment option for mild to moderate CIPN in practice.

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